2-FLUORO-6-NITROBENZALDEHYDE
- Product Name
- 2-FLUORO-6-NITROBENZALDEHYDE
- CAS No.
- 1644-82-2
- Chemical Name
- 2-FLUORO-6-NITROBENZALDEHYDE
- Synonyms
- 2-FLUORO-6-NITROBENZAL;2-fluro-6-nitrobenzaldehyde;2-FLUORO-6-NITROBENZALDEHYDE;3-Fluoro-2-formylnitrobenzene;BENZALDEHYDE,2-FLUORO-6-NITRO-;5-(Trifluoromethyl)acetophenone;2-Fluoro-6-nitrobenzaldehyde99%;2-Fluoro-6-nitrobenzaldehyde 99%
- CBNumber
- CB71484673
- Molecular Formula
- C7H4FNO3
- Formula Weight
- 169.11
- MOL File
- 1644-82-2.mol
2-FLUORO-6-NITROBENZALDEHYDE Property
- Melting point:
- 62-63℃
- Boiling point:
- 287℃
- Density
- 1.443
- Flash point:
- 127℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline needles
- color
- Light brown
- InChI
- InChI=1S/C7H4FNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H
- InChIKey
- LMTKLMMRJDNPFT-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C([N+]([O-])=O)C=CC=C1F
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F621933
- Product name
- 2-Fluoro-6-nitrobenzaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4654-3-Z3
- Product name
- 2-Fluoro-6-nitrobenzaldehyde
- Purity
- 99%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- W3585
- Product name
- 2-Fluoro-6-nitrobenzaldehyde
- Packaging
- 1g
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 081535
- Product name
- 2-Fluoro-6-nitrobenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- PC5841
- Product name
- 2-Fluoro-6-nitrobenzaldehyde
- Purity
- 99%
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
2-FLUORO-6-NITROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Fluoro-6-nitrobenzaldehyde is a benzaldehyde analogue with a benzene ring structure containing substitutable groups fluorine and nitro. It can be used as an electron donor to reduce a range of electron acceptors including piperazine. Studies have shown that 2-Fluoro-6-nitrobenzaldehyde has antitumour effects, inhibiting the growth of cancer cells both in vivo and in vitro, and is a potential antipancreatic cancer drug.
Synthesis
769-10-8
4637-24-5
1644-82-2
General procedure for the synthesis of 2-fluoro-6-nitrobenzaldehyde from 2-fluoro-6-nitrotoluene and N,N-dimethylformamide dimethyl acetal: A mixture of 2-fluoro-6-nitrotoluene and N,N-dimethylformamide dimethyl acetal (2.75 eq.) was heated to 135 °C and kept for 12 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly added dropwise to a pre-prepared water/DMF (1:1, 1.1 M) solution of NaIO4 (2.75 equiv.). After the dropwise addition, the reaction mixture was stirred at room temperature for 3 hours. Subsequently, the reaction mixture was filtered and the solid was washed with toluene. The filtrate was transferred to a partition funnel to separate the organic and aqueous layers. The organic layer was washed with water and dried with anhydrous Na2SO4. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel with gradient elution using EtOAc/petroleum ether (1:30) as eluent to finally obtain 2-fluoro-6-nitrobenzaldehyde in 23% yield. Mass spectrometry analysis (ES+): the theoretical value of C7H4FNO3 was 169 and the measured value was 170 (M+H)+.
References
[1] Patent: WO2010/13037, 2010, A1. Location in patent: Page/Page column 62
2-FLUORO-6-NITROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-6-NITROBENZALDEHYDE Suppliers
- Tel
- 021-68080707 18079794756
- soloman.lee@chemlin.com.cn
- Country
- China
- ProdList
- 8473
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- 13598610367 0373-7129549
- Fax
- 0373-8369699
- 2468833170@qq.com
- Country
- China
- ProdList
- 932
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
View Lastest Price from 2-FLUORO-6-NITROBENZALDEHYDE manufacturers
- Product
- 2-FLUORO-6-NITROBENZALDEHYDE 1644-82-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12