5-BROMO-2-METHYL-2H-INDAZOLE

Product Name: 5-BROMO-2-METHYL-2H-INDAZOLE
CAS No.: 465529-56-0
Chemical Name: 5-BROMO-2-METHYL-2H-INDAZOLE
Synonyms: 5-BROMO-2-METHYLINDAZOLE;2-Methyl-5-bromoindazole;2-methyl-5-bromo -2H-indazo;5-BROMO-2-METHYL-2H-INDAZOLE;2-Methyl-5-bromo-2H-indazole;2H-INDAZOLE, 5-BROMO-2-METHYL-
CBNumber: CB71494111
Molecular Formula: C8H7BrN2
Formula Weight: 211.06
MOL File: 465529-56-0.mol

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5-BROMO-2-METHYL-2H-INDAZOLE Property

Boiling point:: 322.7±15.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -0.06±0.30(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C8H7BrN2/c1-11-5-6-4-7(9)2-3-8(6)10-11/h2-5H,1H3
InChIKey: QFZOHVHNTZTZMJ-UHFFFAOYSA-N
SMILES: N1=C2C(C=C(Br)C=C2)=CN1C

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B697258
Product name: 5-Bromo-2-methylindazole
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54477
Product name: 5-Bromo-2-methylindazole
Packaging: 500mg
Price: $115
Updated: 2021/12/16

Apolloscientific

Product number: OR43568
Product name: 5-Bromo-2-methyl-2H-indazole
Packaging: 250mg
Price: $29
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-V0
Product name: 5-Bromo-2-methyl-2H-indazole
Packaging: 250mg
Price: $32
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB54477
Product name: 5-Bromo-2-methylindazole
Packaging: 1g
Price: $297.4
Updated: 2021/12/16

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5-BROMO-2-METHYL-2H-INDAZOLE Chemical Properties,Usage,Production

Synthesis

53857-57-1

74-88-4

465529-56-0

465529-57-1

To a solution of 5-bromo-1H-indazole (0.19 g, 0.94 mmol) in THF (3 mL), NaH (0.04 g, 1.03 mmol) was slowly added at 0 °C. The reaction mixture was stirred at this temperature for 1 h, followed by the addition of iodomethane (0.09 mL, 1.41 mmol) at 0 °C. The reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with water and concentrated under reduced pressure. The residue was diluted with water and extracted twice with dichloromethane (DCM). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Purification of the crude product by fast column chromatography (eluent: hexane/ethyl acetate = 10:1) afforded 5-bromo-1-methyl-1H-indazole (ii) (88.7 mg, 42.5%) and 5-bromo-2-methyl-2H-indazole (iii) (60.9 mg, 29%), both as white solids. The 1H-NMR (400 MHz, DMSO-d6) δ ppm of compound ii: 8.02 (d, 1H), 7.99 (d, 1H), 7.64 (d, 1H), 7.50 (dd, 1H), 4.04 (s, 3H). lcms (Method A): [MH]+ = 211/213, tR = 5.19 min. compound iii The 1H-NMR (400 MHz, DMSO-d6) δ ppm: 8.33 (s, 1H), 7.95 (d, 1H), 7.57 (d, 1H), 7.30 (dd, 1H), 4.16 (s, 3H). lCMS (Method A): [MH]+ = 211/213, tR = 4.95 min.

References

[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135
[2] Journal of Organic Chemistry, 2018, vol. 83, # 12, p. 6334 - 6353
[3] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 60-61
[4] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 59
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157

5-BROMO-2-METHYL-2H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-METHYL-2H-INDAZOLE Suppliers

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View Lastest Price from 5-BROMO-2-METHYL-2H-INDAZOLE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2019-07-10

465529-56-0, 5-BROMO-2-METHYL-2H-INDAZOLERelated Search:

5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine 5-Bromo-2-methyl-2H-indazole-3-carbaldehyde 6-BROMO-1-METHYL-1H-INDAZOLE 5-BROMO-1-METHYL-1H-INDAZOLE 5-BROMO-2-METHYL-2H-INDAZOLE

5-BROMO-2-METHYL-2H-INDAZOLE

2H-INDAZOLE, 5-BROMO-2-METHYL-

5-BROMO-2-METHYLINDAZOLE

2-Methyl-5-bromo-2H-indazole

2-Methyl-5-bromoindazole

2-methyl-5-bromo -2H-indazo

465529-56-0

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