5-BROMO-2-METHYL-2H-INDAZOLE
- Product Name
- 5-BROMO-2-METHYL-2H-INDAZOLE
- CAS No.
- 465529-56-0
- Chemical Name
- 5-BROMO-2-METHYL-2H-INDAZOLE
- Synonyms
- 5-BROMO-2-METHYLINDAZOLE;2-Methyl-5-bromoindazole;2-methyl-5-bromo -2H-indazo;5-BROMO-2-METHYL-2H-INDAZOLE;2-Methyl-5-bromo-2H-indazole;2H-INDAZOLE, 5-BROMO-2-METHYL-
- CBNumber
- CB71494111
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 465529-56-0.mol
5-BROMO-2-METHYL-2H-INDAZOLE Property
- Boiling point:
- 322.7±15.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.06±0.30(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C8H7BrN2/c1-11-5-6-4-7(9)2-3-8(6)10-11/h2-5H,1H3
- InChIKey
- QFZOHVHNTZTZMJ-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(Br)C=C2)=CN1C
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697258
- Product name
- 5-Bromo-2-methylindazole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB54477
- Product name
- 5-Bromo-2-methylindazole
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- OR43568
- Product name
- 5-Bromo-2-methyl-2H-indazole
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 3H32-9-V0
- Product name
- 5-Bromo-2-methyl-2H-indazole
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- FB54477
- Product name
- 5-Bromo-2-methylindazole
- Packaging
- 1g
- Price
- $297.4
- Updated
- 2021/12/16
5-BROMO-2-METHYL-2H-INDAZOLE Chemical Properties,Usage,Production
Synthesis
53857-57-1
74-88-4
465529-56-0
465529-57-1
To a solution of 5-bromo-1H-indazole (0.19 g, 0.94 mmol) in THF (3 mL), NaH (0.04 g, 1.03 mmol) was slowly added at 0 °C. The reaction mixture was stirred at this temperature for 1 h, followed by the addition of iodomethane (0.09 mL, 1.41 mmol) at 0 °C. The reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with water and concentrated under reduced pressure. The residue was diluted with water and extracted twice with dichloromethane (DCM). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Purification of the crude product by fast column chromatography (eluent: hexane/ethyl acetate = 10:1) afforded 5-bromo-1-methyl-1H-indazole (ii) (88.7 mg, 42.5%) and 5-bromo-2-methyl-2H-indazole (iii) (60.9 mg, 29%), both as white solids. The 1H-NMR (400 MHz, DMSO-d6) δ ppm of compound ii: 8.02 (d, 1H), 7.99 (d, 1H), 7.64 (d, 1H), 7.50 (dd, 1H), 4.04 (s, 3H). lcms (Method A): [MH]+ = 211/213, tR = 5.19 min. compound iii The 1H-NMR (400 MHz, DMSO-d6) δ ppm: 8.33 (s, 1H), 7.95 (d, 1H), 7.57 (d, 1H), 7.30 (dd, 1H), 4.16 (s, 3H). lCMS (Method A): [MH]+ = 211/213, tR = 4.95 min.
References
[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135
[2] Journal of Organic Chemistry, 2018, vol. 83, # 12, p. 6334 - 6353
[3] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 60-61
[4] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 59
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157
5-BROMO-2-METHYL-2H-INDAZOLE Preparation Products And Raw materials
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View Lastest Price from 5-BROMO-2-METHYL-2H-INDAZOLE manufacturers
- Product
- 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-BROMO-2-METHYL-2H-INDAZOLE 465529-56-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2019-07-10