4,6-dichloro-2-(trifluoromethyl)pyrimidine
- Product Name
- 4,6-dichloro-2-(trifluoromethyl)pyrimidine
- CAS No.
- 705-24-8
- Chemical Name
- 4,6-dichloro-2-(trifluoromethyl)pyrimidine
- Synonyms
- 4, 6-dichloro-2-trifluoromethymidine;4,6-DICHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE;PyriMidine,4,6-dichloro-2-(trifluoroMethyl)-;4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%;4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+% ISO 9001：2015 REACH
- CBNumber
- CB71494494
- Molecular Formula
- C5HCl2F3N2
- Formula Weight
- 216.98
- MOL File
- 705-24-8.mol
4,6-dichloro-2-(trifluoromethyl)pyrimidine Property
- Boiling point:
- 50-52℃/5mm
- Density
- 1.585g/mLat 25℃
- refractive index
- n20/D 1.468
- Flash point:
- >110°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- -7.59±0.30(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C5HCl2F3N2/c6-2-1-3(7)12-4(11-2)5(8,9)10/h1H
- InChIKey
- QFWVAJQVYBRTCL-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC(Cl)=CC(Cl)=N1
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- 2922
- WGK Germany
- 3
- HazardClass
- IRRITANT, AVOID SKIN CONTACT
- PackingGroup
- Ⅱ
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 755044
- Product name
- 4,6-Dichloro-2-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $87.9
- Updated
- 2023/06/20
- Product number
- D437218
- Product name
- 4,6-Dichloro-2-trifluoromethylpyrimidine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D437218
- Product name
- 4,6-Dichloro-2-trifluoromethylpyrimidine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 043493
- Product name
- 4,6-Dichloro-2-trifluoromethylpyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 055415
- Product name
- 4,6-Dichloro-2-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
4,6-dichloro-2-(trifluoromethyl)pyrimidine Chemical Properties,Usage,Production
Uses
4,6-Dichloro-2-trifluoromethylpyrimidine
Synthesis
672-47-9
705-24-8
Example 2: Synthesis of 4,6-dichloro-2-trifluoromethylpyrimidine (Compound V) Step 2: In a 5L round-bottomed flask equipped with a mechanical stirrer, 4,6-dihydroxy-2-trifluoromethylpyrimidine (VI; 540 g; 3.0 mol) was mixed with phosphorus trichloride (1300 mL; 2147 g; 14.0 mol). Triethylamine (607 g; 6.0 mol) was added slowly over a period of 1 h. Exothermic phenomena were observed during the reaction. Subsequently, the reaction mixture was heated on a dry bath for 3 hours. Upon completion of the reaction, the mixture was cooled to 40°C and then slowly poured into a mixture consisting of 10 kg of ice and 2 kg of water under continuous stirring. The mixture was extracted using dichloromethane (4 x 0.5 L). The organic phases were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under vacuum to give the crude product V. For further purification, the purified product in the form of a colorless liquid was obtained by distillation (steam bath, 48°-50°C/2 mmHg) in 78.8% yield. Elemental Analysis Results: Calculated values (C5HCl2F3N2) : C, 27.68; H, 0.47; N, 12.91. Measured values: C, 27.45; H, 0.39; N, 12.86.
References
[1] Patent: US4963678, 1990, A
[2] Patent: WO2005/95357, 2005, A2. Location in patent: Page/Page column 140; 141
[3] Patent: CN106883185, 2017, A. Location in patent: Paragraph 0018
4,6-dichloro-2-(trifluoromethyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-dichloro-2-(trifluoromethyl)pyrimidine manufacturers
- Product
- 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+% 705-24-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+% 705-24-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23