6-BROMO-2-METHYL-2H-INDAZOLE
- Product Name
- 6-BROMO-2-METHYL-2H-INDAZOLE
- CAS No.
- 590417-95-1
- Chemical Name
- 6-BROMO-2-METHYL-2H-INDAZOLE
- Synonyms
- 2-Methyl-6-bromoindazole;6-BROMO-2-METHYLINDAZOLE;6-BROMO-2-METHYL-2H-INDAZOLE;2H-INDAZOLE, 6-BROMO-2-METHYL-
- CBNumber
- CB71495941
- Molecular Formula
- C8H7BrN2
- Formula Weight
- 211.06
- MOL File
- 590417-95-1.mol
6-BROMO-2-METHYL-2H-INDAZOLE Property
- Boiling point:
- 322.7±15.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.02±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H7BrN2/c1-11-5-6-2-3-7(9)4-8(6)10-11/h2-5H,1H3
- InChIKey
- BVYFYDANLZQCPV-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=CC(Br)=C2)=CN1C
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697273
- Product name
- 6-Bromo-2-methyl-2H-indazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B697273
- Product name
- 6-Bromo-2-methyl-2H-indazole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB54478
- Product name
- 6-Bromo-2-methylindazole
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-D0267
- Product name
- 6-Bromo-2-methyl-2H-indazole
- Purity
- 99.60%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- OR43559
- Product name
- 6-Bromo-2-methyl-2H-indazole
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
6-BROMO-2-METHYL-2H-INDAZOLE Chemical Properties,Usage,Production
Uses
6-Bromo-2-methyl-2H-indazole is a 2H-Indazoles compound, one class of the most important nitrogen-containing heterocyclic compounds. The 2H-indazole motif is widely present in bioactive natural products and drug molecules that exhibit distinctive bioactivities.[1]
Synthesis
74-88-4
590417-94-0
590417-95-1
Example 402 Part A: To a solution of tetrahydrofuran (THF) (50 mL) of 6-bromoindazole (402A) (5.0 g, 25.4 mmol) was slowly added sodium hydride (95%, 672 mg, 26.6 mmol) under ice bath cooling conditions. The reaction mixture was stirred for 30 min. Subsequently, iodomethane (6.36 mL, 102 mmol) was added dropwise at room temperature. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride and the organic and aqueous layers were separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: ethyl acetate/hexane gradient) afforded 1-methyl-6-bromoindazole (402B) (2.71 g, 51% yield) as a yellow oil and 2-methyl-6-bromoindazole (402C) (2.28 g, 43% yield) as a yellow crystalline solid, respectively. HPLC-MS analysis of 402B showed that the retention time t R = 1.69 min (UV 254 nm); calculated molecular weight C8H7BrN2 was 209.98, measured LCMS m/z 211.0 ([M + H]+). 402C was analyzed by HPLC-MS: retention time t R = 1.54 min (UV 254 nm); calculated molecular weight C8H7BrN2 was 209.98, measured LCMS m/z 211.0 ([M + H]+). 211.0 ([M + H]+).
References
[1] Zixian Yang , Changduo Pan, Jin-Tao Yu . “Recent advances in C–H functionalization of 2H-indazoles.” Organic & Biomolecular Chemistry 20 39 (2022): Pages 7746-7764.
6-BROMO-2-METHYL-2H-INDAZOLE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-BROMO-2-METHYL-2H-INDAZOLE manufacturers
- Product
- 6-Bromo-2-methyl-2H-indazole 590417-95-1
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 6-BROMO-2-METHYL-2H-INDAZOLE 590417-95-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2019-12-25