6-BROMO-2-CHLORO-QUINOLINE
- Product Name
- 6-BROMO-2-CHLORO-QUINOLINE
- CAS No.
- 1810-71-5
- Chemical Name
- 6-BROMO-2-CHLORO-QUINOLINE
- Synonyms
- 6-broMo-2-chloro-;2-Chloro-6-bromoquinoline;6-BROMO-2-CHLORO-QUINOLINE;Quinoline, 6-bromo-2-chloro-;6-Bromo-2-chloroquinoline,96%;4,4'',4''-TRIIODOTRIPHENYLAMINE;6-Bromo-2-chloro-1-azanaphthalene;6-BROMO-2-CHLORO-QUINOLINE ISO 9001:2015 REACH
- CBNumber
- CB7772562
- Molecular Formula
- C9H5BrClN
- Formula Weight
- 242.5
- MOL File
- 1810-71-5.mol
6-BROMO-2-CHLORO-QUINOLINE Property
- Melting point:
- 148-150℃
- Boiling point:
- 325.7±22.0 °C(Predicted)
- Density
- 1.673±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in Chloroform and Methanol
- form
- Solid
- pka
- -0.48±0.43(Predicted)
- color
- White Crystalline
- InChI
- InChI=1S/C9H5BrClN/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H
- InChIKey
- YXRDWUJAJLDABJ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(Br)=CC=2)C=CC=1Cl
- CAS DataBase Reference
- 1810-71-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5628
- Product name
- 6-Bromo-2-chloroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $58
- Updated
- 2025/07/31
- Product number
- B5628
- Product name
- 6-Bromo-2-chloroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $231
- Updated
- 2025/07/31
- Product number
- B682410
- Product name
- 6-Bromo-2-chloroquinoline
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- B682410
- Product name
- 6-Bromo-2-chloroquinoline
- Packaging
- 2.5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B682410
- Product name
- 6-Bromo-2-chloroquinoline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
6-BROMO-2-CHLORO-QUINOLINE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
It is used as a pharmaceutical intermediate.
Synthesis
1810-66-8
1810-71-5
Step 1: 6-Bromoquinolin-2(1H)-one (1.0 g, 4.4 mmol, 1.0 eq.) was dissolved in phosphoryl chloride (15 mL), stirred and heated to 100 °C, and reacted for 15 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and water was added to the residue. The precipitated solid was collected by filtration and dried under vacuum to give 6-bromo-2-chloroquinoline as a pink solid (1.0 g, 92% yield).LC-MS (ES) m/z = 241.0, 243.0 [M + H]+.1H NMR (400 MHz, DMSO-d6) δ ppm: 7.41 (d, J = 8.4 Hz, 1H), 7.79-7.82 ( m, 1H), 7.89 (d, J = 9.2 Hz, 1H), 7.98-7.99 (m, 1H), 8.02 (d, J = 8.8 Hz, 1H).
References
[1] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 78
[2] Journal of the American Chemical Society, 2016, vol. 138, # 25, p. 7808 - 7811
[3] Patent: WO2006/132739, 2006, A2. Location in patent: Page/Page column 36
[4] European Journal of Medicinal Chemistry, 2000, vol. 35, # 10, p. 931 - 940
[5] Patent: WO2009/39127, 2009, A1. Location in patent: Page/Page column 181
6-BROMO-2-CHLORO-QUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-2-CHLORO-QUINOLINE manufacturers
- Product
- 6-BROMO-2-CHLORO-QUINOLINE 1810-71-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-05