ChemicalBook > CAS DataBase List > 6-BROMO-2-CHLORO-QUINOLINE

6-BROMO-2-CHLORO-QUINOLINE

Product Name
6-BROMO-2-CHLORO-QUINOLINE
CAS No.
1810-71-5
Chemical Name
6-BROMO-2-CHLORO-QUINOLINE
Synonyms
6-broMo-2-chloro-;2-Chloro-6-bromoquinoline;6-BROMO-2-CHLORO-QUINOLINE;Quinoline, 6-bromo-2-chloro-;6-Bromo-2-chloroquinoline,96%;4,4'',4''-TRIIODOTRIPHENYLAMINE;6-Bromo-2-chloro-1-azanaphthalene;6-BROMO-2-CHLORO-QUINOLINE ISO 9001:2015 REACH
CBNumber
CB7772562
Molecular Formula
C9H5BrClN
Formula Weight
242.5
MOL File
1810-71-5.mol
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6-BROMO-2-CHLORO-QUINOLINE Property

Melting point:
148-150℃
Boiling point:
325.7±22.0 °C(Predicted)
Density 
1.673±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in Chloroform and Methanol
form 
Solid
pka
-0.48±0.43(Predicted)
color 
White Crystalline
InChI
InChI=1S/C9H5BrClN/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5H
InChIKey
YXRDWUJAJLDABJ-UHFFFAOYSA-N
SMILES
N1C2C(=CC(Br)=CC=2)C=CC=1Cl
CAS DataBase Reference
1810-71-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5628
Product name
6-Bromo-2-chloroquinoline
Purity
>98.0%(GC)
Packaging
1g
Price
$58
Updated
2025/07/31
TCI Chemical
Product number
B5628
Product name
6-Bromo-2-chloroquinoline
Purity
>98.0%(GC)
Packaging
5g
Price
$231
Updated
2025/07/31
TRC
Product number
B682410
Product name
6-Bromo-2-chloroquinoline
Packaging
1g
Price
$100
Updated
2021/12/16
TRC
Product number
B682410
Product name
6-Bromo-2-chloroquinoline
Packaging
2.5g
Price
$130
Updated
2021/12/16
TRC
Product number
B682410
Product name
6-Bromo-2-chloroquinoline
Packaging
100mg
Price
$45
Updated
2021/12/16
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6-BROMO-2-CHLORO-QUINOLINE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

It is used as a pharmaceutical intermediate.

Synthesis

1810-66-8

1810-71-5

Step 1: 6-Bromoquinolin-2(1H)-one (1.0 g, 4.4 mmol, 1.0 eq.) was dissolved in phosphoryl chloride (15 mL), stirred and heated to 100 °C, and reacted for 15 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and water was added to the residue. The precipitated solid was collected by filtration and dried under vacuum to give 6-bromo-2-chloroquinoline as a pink solid (1.0 g, 92% yield).LC-MS (ES) m/z = 241.0, 243.0 [M + H]+.1H NMR (400 MHz, DMSO-d6) δ ppm: 7.41 (d, J = 8.4 Hz, 1H), 7.79-7.82 ( m, 1H), 7.89 (d, J = 9.2 Hz, 1H), 7.98-7.99 (m, 1H), 8.02 (d, J = 8.8 Hz, 1H).

References

[1] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 78
[2] Journal of the American Chemical Society, 2016, vol. 138, # 25, p. 7808 - 7811
[3] Patent: WO2006/132739, 2006, A2. Location in patent: Page/Page column 36
[4] European Journal of Medicinal Chemistry, 2000, vol. 35, # 10, p. 931 - 940
[5] Patent: WO2009/39127, 2009, A1. Location in patent: Page/Page column 181

6-BROMO-2-CHLORO-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-2-CHLORO-QUINOLINE Suppliers

Chengdu Zokrio Pharmaceutical Co., Ltd
Tel
18190925036
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2875752953@qq.com
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China
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508
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58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd.
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18014824111
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908320070@qq.com
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China
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65
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58
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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24529
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Energy Chemical
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021-021-58432009 400-005-6266
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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China
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35896
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
Fax
+86-21-54096319
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sales@sinch.com.cn
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China
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Changzhou Huanling Chemical Co., Ltd.
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0519-89803565 13776850645
Fax
0519-89803575
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info4@huanlingchem.com
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China
ProdList
891
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View Lastest Price from 6-BROMO-2-CHLORO-QUINOLINE manufacturers

Career Henan Chemical Co
Product
6-BROMO-2-CHLORO-QUINOLINE 1810-71-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-05