17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL

Product Name: 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
CAS No.: 150270-08-9
Chemical Name: 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
Synonyms: DL 3631;GledanaMycin;Geldanamycin, 4,5-dihydro-;17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL
CBNumber: CB71497112
Molecular Formula: C29H42N2O9
Formula Weight: 562.65
MOL File: 150270-08-9.mol

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17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Property

Boiling point:: 767.9±60.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
RTECS: LX8925000
storage temp.: -20°C
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
form: solid
pka: 8.88±0.70(Predicted)
color: Purple
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67023
Product name: 17-DMAG, 98%
Packaging: 1mg
Price: $317
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000693
Product name: 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN
Purity: 95.00%
Packaging: 10MG
Price: $650.27
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000693
Product name: 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN
Purity: 95.00%
Packaging: 50MG
Price: $752.14
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000693
Product name: 17-[2-(DIMETHYLAMINO)ETHYL]AMINO-17-DESMETHOXYGELDANAMYCIN
Purity: 95.00%
Packaging: 250MG
Price: $868.56
Updated: 2021/12/16

Matrix Scientific

Product number: 089480
Product name: 17-Dimethylaminogeldanamycin
Packaging: 10mg
Price: $1890
Updated: 2021/12/16

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17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Chemical Properties,Usage,Production

Description

17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.

Uses

17-Dimethylaminogeldanamycin is a metabolite/analog of geldanamycin(G304500). Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Definition

ChEBI: Alvespimycin is a 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. It has a role as a Hsp90 inhibitor. It is a secondary amino compound, a tertiary amino compound, an ansamycin, a member of 1,4-benzoquinones and a carbamate ester. It is functionally related to a geldanamycin.

References

1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637 2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813

17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL Suppliers

China 7 United Kingdom 1 United States 2 Global 10

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17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL

GledanaMycin

Geldanamycin, 4,5-dihydro-

DL 3631

150270-08-9

antibiotic