ChemicalBook > CAS DataBase List > 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE

2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE

Uses

Product Name: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE
CAS No.: 115279-57-7
Chemical Name: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE
Synonyms: 2-(4-Aminophenyl)-2-methylpropanonitril;2-(4-Aminophenyl)-2-methylpropionitrile;2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE;Benzeneacetonitrile, 4-amino-α,α-dimethyl-;Benzeneacetonitrile, 4-aMino-a,a-diMethyl-;1,1-dimethyl-1-(4-aminophenyl)-acetonitrile;"4-Amino-α, α-dimethylbenzeneacetonitrile 13C6";2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE ISO 9001：2015 REACH
CBNumber: CB71497617
Molecular Formula: C10H12N2
Formula Weight: 160.22
MOL File: 115279-57-7.mol

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2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE Property

Boiling point:: 173-174 °C(Press: 10 Torr)
Density: 1.055±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.63±0.10(Predicted)
Appearance: Light brown to off-white Solid
InChI: InChI=1S/C10H12N2/c1-10(2,7-11)8-3-5-9(12)6-4-8/h3-6H,12H2,1-2H3
InChIKey: VXDPOGVDHHJTDY-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(N)C=C1)(C)C#N

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A577323
Product name: 2-(4-Aminophenyl)-2-methylpropanenitrile
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA144120
Product name: 2-(4-Aminophenyl)-2-methylpropanenitrile
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: OR952433
Product name: 2-(4-Aminophenyl)-2-methylpropanenitrile
Packaging: 1g
Price: $149
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA144120
Product name: 2-(4-Aminophenyl)-2-methylpropanenitrile
Packaging: 1g
Price: $170
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-1-8X
Product name: 2-(4-Aminophenyl)-2-methylpropanenitrile
Purity: 96%
Packaging: 1g
Price: $176
Updated: 2021/12/16

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2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE Chemical Properties,Usage,Production

Uses

2-(4-Aminophenyl)-2-methylpropionitrile is used as an organic and pharmaceutical intermediate.

Chemical Properties

light yellow crystalline

Synthesis

71825-51-9

115279-57-7

General procedure for the synthesis of 2-(4-aminophenyl)-2-methylpropionitrile from 2-methyl-2-(4-nitrophenyl)propanenitrile: 2-methyl-2-(4-nitrophenyl)propanenitrile (1.0 mmol) was dissolved in ethyl acetate (20 mL) and stannous chloride dihydrate (3.52 g, 15.86 mmol) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was alkalized with aqueous sodium carbonate. The organic layer was separated, washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate/petroleum ether (1:9, v/v) to afford 2-(4-aminophenyl)-2-methylpropanenitrile (0.45 g, 89% yield) as an oil.

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4834 - 4848
[2] Patent: US2009/137595, 2009, A1
[3] Patent: WO2012/116237, 2012, A2. Location in patent: Page/Page column 119
[4] Patent: US2015/320727, 2015, A1. Location in patent: Paragraph 0555; 0556
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7585 - 7596

2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE manufacturers

Honest Joy Holdings Limited

Product: 2-(4-Aminophenyl)-2-methylpropanenitrile 115279-57-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE 115279-57-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

115279-57-7, 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILERelated Search:

1-(4-Aminophenyl)cyclopentanecarbonitrile 2-methyl-2-(4-nitrophenyl)propanenitrile TRIS-[4-(TRITYLAMINO)-PHENYL]ACETONITRILE 1-(4-NITRO-PHENYL)-CYCLOPROPANECARBONITRILE BIS-(4-N,N-DIMETHYLAMINOPHENYL) PHENYLACTONITRILE BASIC FUCHSIN LEUCONITRILE BIS(4-N,N-DIMETHYLAMINOPHENYL)-(2,3,4,5,6-PENTAFLUOROPHENYL) ACETONITRILE BIS(4'-N,N-DIMETHYLAMINOPHENYL)-(2-FLUOROPHENYL)ACETONITRILE ASISCHEM D50965 BIS(4-N,N-DIETHYLAMINO-PHENYL)-(4-N-ETHYLAMINO-NAPHTHALEN-1-YL) ACETONITRILE 4-(N,N-DIMETHYLAMINO)-A,A-BIS[4-(DIMETHYL AMINO)PHENYL]-BENZENEACETONITRILE-C15N RHODAMINE 6G LEUCONITRILE 4-(N,N-DIMETHYLAMINO)-A,A-BIS[4-(DIMETHYL AMINO)PHENYL]-BENZENEACETONITRILE-13CN 1,2-DI[4-(1-CYANO-1-PHENYLPROPYL)PHENYL]DIAZ-1-EN-1-IUM-1-OLATE (4-[CYANO(DIPHENYL)METHYL]PHENYL)(DIPHENYLMETHYLIDENE)AMMONIUMOLATE 4-(N,N-DIMETHYLAMINO)-A,A-BIS[4-(DIMETHYL AMINO)PHENYL]-BENZENE ACETONITRILE BIS(4-N,N-DIMETHYL AMINOPHENYL)-(2-METHYL INDOL-3-YL)ACETONITRILE BIS(4'-N,N-DIMETHYLAMINOPHENYL)-(4-FLUOROPHENYL)ACETONITRILE

2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE

2-(4-Aminophenyl)-2-methylpropionitrile

1,1-dimethyl-1-(4-aminophenyl)-acetonitrile

Benzeneacetonitrile, 4-aMino-a,a-diMethyl-

Benzeneacetonitrile, 4-amino-α,α-dimethyl-

2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE ISO 9001：2015 REACH

"4-Amino-α, α-dimethylbenzeneacetonitrile 13C6"

2-(4-Aminophenyl)-2-methylpropanonitril

115279-57-7