4-Chloroindole-3-carbaldehyde
- Product Name
- 4-Chloroindole-3-carbaldehyde
- CAS No.
- 876-72-2
- Chemical Name
- 4-Chloroindole-3-carbaldehyde
- Synonyms
- 4-CHLOROINDOLE-3-CARBALDEHYDE;4-CHLOROINDOLE-3-CARBOXALDEHYDE;4-CHLORO-1H-INDOLE-3-CARBALDEHYDE;4-CHLOROINDOLE-3-CARBOXALDEHYDE 98%;4-Chloro-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 4-chloro-;4-Chloro-1H-indole-3-carboxaldehyde 98%
- CBNumber
- CB7150119
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 876-72-2.mol
4-Chloroindole-3-carbaldehyde Property
- Melting point:
- 164 °C
- Boiling point:
- 373.4±22.0 °C(Predicted)
- Density
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 14.60±0.30(Predicted)
- Appearance
- Light brown to brown Solid
- CAS DataBase Reference
- 876-72-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C360365
- Product name
- 4-Chloroindole-3-carbaldehyde
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C360365
- Product name
- 4-Chloroindole-3-carbaldehyde
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 071720
- Product name
- 4-Chloroindole-3-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- B476
- Product name
- 4-Chloroindole-3-carbaldehyde
- Packaging
- 250mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 4H15-5-21
- Product name
- 4-Chloro-1H-indole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
4-Chloroindole-3-carbaldehyde Chemical Properties,Usage,Production
Synthesis
25235-85-2
68-12-2
876-72-2
Trichlorophosphorus (3.55 mL) was added slowly and dropwise to N,N-dimethylformamide (10.63 mL) in stirring at 10-20 °C. Subsequently, a solution of 4-chloroindole (2 g, 13.19 mmol) was added at 20-30 °C. The reaction mixture was stirred at 35-37 °C for 45 min, after which it was poured into a stirred mixture of ice (28 g) and water (21 mL). The pH of the reaction solution was adjusted to 8 by adding a solution of sodium hydroxide (6.86 g) in water (36 mL) at 20-30 °C. The mixture was boiled for 5 min, cooled to room temperature and then extracted with ethyl acetate and washed with brine. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 60% petroleum ether/ethyl acetate as eluent to give 4-chloroindole-3-carboxaldehyde (1.037 g, 44% yield) as an off-white solid. m/z = 180 [M+H]+ by LC-MS.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9179 - 9195
[2] Organic Letters, 2013, vol. 15, # 17, p. 4330 - 4333
[3] Patent: WO2016/44777, 2016, A1. Location in patent: Page/Page column 72; 73
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 6, p. 1793 - 1798
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 36, p. 6647 - 6651
4-Chloroindole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloroindole-3-carbaldehyde Suppliers
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View Lastest Price from 4-Chloroindole-3-carbaldehyde manufacturers
- Product
- 4-Chloroindole-3-carboxaldehyde 876-72-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 4-Chloroindole-3-carbaldehyde 876-72-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.2%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 4-Chloroindole-3-carbaldehyde 876-72-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02