5-BROMO-6-FLUORO-1H-INDAZOLE

Product Name: 5-BROMO-6-FLUORO-1H-INDAZOLE
CAS No.: 105391-70-6
Chemical Name: 5-BROMO-6-FLUORO-1H-INDAZOLE
Synonyms: 5-BroMo-6-fluoro-1H-;5-BROMO-6-FLUOROINDAZOLE;5-BROMO-6-FLUORO-1H-INDAZOLE;1H-Indazole, 5-bromo-6-fluoro-
CBNumber: CB71502018
Molecular Formula: C7H4BrFN2
Formula Weight: 215.02
MOL File: 105391-70-6.mol

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5-BROMO-6-FLUORO-1H-INDAZOLE Property

Boiling point:: 332.2±22.0 °C(Predicted)
Density: 1.861
storage temp.: Sealed in dry,Room Temperature
pka: 11.95±0.40(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C7H4BrFN2/c8-5-1-4-3-10-11-7(4)2-6(5)9/h1-3H,(H,10,11)
InChIKey: ZNNFNEIFQIAWNY-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Br)C(F)=C2)C=N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B685938
Product name: 5-Bromo-6-fluoro-1H-indazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105524
Product name: 5-bromo-6-fluoro-1h-indazole
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105524
Product name: 5-bromo-6-fluoro-1h-indazole
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: PC402011
Product name: 5-Bromo-6-fluoro-1H-indazole
Packaging: 250mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105524
Product name: 5-bromo-6-fluoro-1h-indazole
Packaging: 500mg
Price: $160
Updated: 2021/12/16

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5-BROMO-6-FLUORO-1H-INDAZOLE Chemical Properties,Usage,Production

Uses

5-Bromo-6-fluoro-1H-indazole is used for optimization and biological evaluation of [(trifluoromethyl)phenyl]indazoles as TRPA1 antagonists.

Synthesis

633335-81-6

105391-70-6

General procedure for the synthesis of 5-bromo-6-fluoro-1H-indazole from 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone: 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone (1.58 g, 6.15 mmol) was dissolved in a solvent mixture of a 3M HCl aqueous solution (20 mL) and methanol (4 mL). The reaction mixture was heated to reflux at 90 °C for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted to 10 with 1 M NaOH aqueous solution. at this point, a colorless solid precipitated from the solution, which was collected by filtration and dried under vacuum to afford the target product 5-bromo-6-fluoro-1H-indazole (1.22 g, 93% yield). The 1H NMR (CDCl3) data of the product were as follows: δ 9.0-10.20 (1H, br), 8.02 (1H, s), 7.97 (1H, d, J = 6.4 Hz), 7.28 (1H, s).

References

[1] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: WO2006/44860, 2006, A2. Location in patent: Page/Page column 37-38
[3] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0619; 0620
[4] Patent: WO2009/32123, 2009, A2. Location in patent: Page/Page column 179-180
[5] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 119

5-BROMO-6-FLUORO-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-6-FLUORO-1H-INDAZOLE Suppliers

China 132 Germany 1 India 1 United Kingdom 2 United States 19 Global 155

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from 5-BROMO-6-FLUORO-1H-INDAZOLE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

105391-70-6, 5-BROMO-6-FLUORO-1H-INDAZOLERelated Search:

6-FLUORO (1H)INDAZOLE 5-BROMO-6-FLUORO-3-METHYL-1H-INDAZOLE 5-BROMO-6-FLUORO-1H-INDAZOLE

1H-Indazole, 5-bromo-6-fluoro-

5-BroMo-6-fluoro-1H-

5-BROMO-6-FLUOROINDAZOLE

5-BROMO-6-FLUORO-1H-INDAZOLE

105391-70-6

Indazoles