ChemicalBook > CAS DataBase List > 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- Product Name
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- CAS No.
- 376592-93-7
- Chemical Name
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- Synonyms
- EltroMbopag I;ltrombopag Impurity; ltrombopag Impurity 9;Eltrombopag Intermediate 2;DarunavirDiamino(2S,3R)Isomer;Eltrombopag Impurity 40 Monomer;Eltrombopag olamine Intermediate 1;3-(3-amino-2-hydroxyphenyl)benzoicaci;3-(3-aMino-2-hydroxyphenyl)benzoic acid;3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC
- CBNumber
- CB71502104
- Molecular Formula
- C13H11NO3
- Formula Weight
- 229.23
- MOL File
- 376592-93-7.mol
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3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Property
- Melting point:
- 222 °C(dec.)
- Boiling point:
- 474.8±45.0 °C(Predicted)
- Density
- 1.364
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 3.99±0.10(Predicted)
- color
- Pale Yellow to Light Brown
- InChI
- InChI=1S/C13H11NO3/c14-11-6-2-5-10(12(11)15)8-3-1-4-9(7-8)13(16)17/h1-7,15H,14H2,(H,16,17)
- InChIKey
- ZXLYSSHNDUXXIN-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC(N)=C2O)=CC=CC(C(O)=O)=C1
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Safety
- HS Code
- 2922.50.5000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- A2944
- Product name
- 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $66
- Updated
- 2025/07/31
TCI Chemical
- Product number
- A2944
- Product name
- 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $244
- Updated
- 2023/06/20
TRC
- Product number
- A611255
- Product name
- 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylicAcid
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA148104
- Product name
- 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
- Packaging
- 100mg
- Price
- $202
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- APN0000594
- Product name
- 3'-AMINO-2'-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1179.15
- Updated
- 2021/12/16
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3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia
Synthesis
376592-58-4
376592-93-7
The general procedure for the synthesis of 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid from 5'-chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid is as follows: 5'-chloro-2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid (Compound 2b) (5.0 g) was dissolved in a methanol (MeOH) (300 mL) and triethylamine (Et3N) (4.75 mL) in a solvent mixture. A palladium/carbon (Pd/C) catalyst (0.5 g) was added to the solution, followed by hydrogenation at room temperature and 10 bar hydrogen pressure for 21 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness. The obtained residue was dissolved in water (40 mL) and the pH was adjusted to 5.5 by dropwise addition of 0.5 M hydrochloric acid (HCl). the resulting suspension was stirred at room temperature for 30 min, followed by filtration. The collected solid product was washed with water (2 x 10 mL) and finally dried at 50 °C/50 mbar to afford the target product 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (BPCA) (3.4 g; yield 86.7%; HPLC purity 97.9%).
References
[1] Patent: WO2013/49605, 2013, A1. Location in patent: Paragraph 0058
3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID manufacturers
Jinan Ruitong Biotech Co., Ltd.
- Product
- 3-(3-Amino-2-hydroxyphenyl)benzoic Acid 376592-93-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3'-amino-2'-hydroxy-(1,1'-biphenyl)-3-carboxylic acid 376592-93-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
Shaanxi TNJONE Pharmaceutical Co., Ltd
- Product
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID 376592-93-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-03-29