3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID

Product Name: 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
CAS No.: 376592-93-7
Chemical Name: 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
Synonyms: EltroMbopag I;ltrombopag Impurity; ltrombopag Impurity 9;Eltrombopag Intermediate 2;DarunavirDiamino(2S,3R)Isomer;Eltrombopag Impurity 40 Monomer;Eltrombopag olamine Intermediate 1;3-(3-amino-2-hydroxyphenyl)benzoicaci;3-(3-aMino-2-hydroxyphenyl)benzoic acid;3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC
CBNumber: CB71502104
Molecular Formula: C13H11NO3
Formula Weight: 229.23
MOL File: 376592-93-7.mol

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3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Property

Melting point:: 222 °C(dec.)
Boiling point:: 474.8±45.0 °C(Predicted)
Density: 1.364
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 3.99±0.10(Predicted)
color: Pale Yellow to Light Brown
InChI: InChI=1S/C13H11NO3/c14-11-6-2-5-10(12(11)15)8-3-1-4-9(7-8)13(16)17/h1-7,15H,14H2,(H,16,17)
InChIKey: ZXLYSSHNDUXXIN-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC(N)=C2O)=CC=CC(C(O)=O)=C1

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Safety

HS Code: 2922.50.5000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2944
Product name: 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: A2944
Product name: 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $244
Updated: 2023/06/20

TRC

Product number: A611255
Product name: 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylicAcid
Packaging: 250mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA148104
Product name: 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid
Packaging: 100mg
Price: $202
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000594
Product name: 3'-AMINO-2'-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1179.15
Updated: 2021/12/16

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3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia

Synthesis

376592-58-4

376592-93-7

The general procedure for the synthesis of 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid from 5'-chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid is as follows: 5'-chloro-2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid (Compound 2b) (5.0 g) was dissolved in a methanol (MeOH) (300 mL) and triethylamine (Et3N) (4.75 mL) in a solvent mixture. A palladium/carbon (Pd/C) catalyst (0.5 g) was added to the solution, followed by hydrogenation at room temperature and 10 bar hydrogen pressure for 21 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness. The obtained residue was dissolved in water (40 mL) and the pH was adjusted to 5.5 by dropwise addition of 0.5 M hydrochloric acid (HCl). the resulting suspension was stirred at room temperature for 30 min, followed by filtration. The collected solid product was washed with water (2 x 10 mL) and finally dried at 50 °C/50 mbar to afford the target product 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (BPCA) (3.4 g; yield 86.7%; HPLC purity 97.9%).

References

[1] Patent: WO2013/49605, 2013, A1. Location in patent: Paragraph 0058

3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Suppliers

Americas 1 China 245 Europe 1 India 32 Japan 1 United Kingdom 2 United States 10 Global 292

GLR Innovations

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View Lastest Price from 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 3-(3-Amino-2-hydroxyphenyl)benzoic Acid 376592-93-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-25

Henan Aochuang Chemical Co.,Ltd.

Product: 3'-amino-2'-hydroxy-(1,1'-biphenyl)-3-carboxylic acid 376592-93-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID 376592-93-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-29

376592-93-7, 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACIDRelated Search:

Eltrombopag 3'-AMINO-BIPHENYL-3-CARBOXYLIC ACID 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID

3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID

Eltrombopag Intermediate 2

EltroMbopag I

3-(3-aMino-2-hydroxyphenyl)benzoic acid

[1,1'-Biphenyl]-3-carboxylic acid, 3'-aMino-2'-hydroxy-

3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC

Eltrombopag olamine Intermediate 1

3'-Amino-2'-hydroxybiphenyl-3-carboxylicAcid&gt

3-(3-amino-2-hydroxyphenyl)benzoicaci

3'-AMINO-2-HYDROXYBIPHENY-3-CARBOXYLIC ACID

3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID ISO 9001：2015 REACH

ltrombopag Impurity 9

3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID 376592-93-7

3’-Amino-2’-hyrdroxybiphenyl-3-carboxylic acid

3'-Amino-2'-hydroxy-3-biphenylcarboxylic acid

Eltrombopag Impurity 40 Monomer

DarunavirDiamino(2S,3R)Isomer

2'-hydroxy-3'-amino-biphenyl-3-carboxylic acid

3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid

3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

ltrombopag Impurity

3′-Amino-2′-Hydroxy-[1,1′]biphenyl-3-carboxylic Acid, CAS 376592-93-7

376592-93-7