Methyl 4-bromothiophene-2-carboxylate
- Product Name
- Methyl 4-bromothiophene-2-carboxylate
- CAS No.
- 62224-16-2
- Chemical Name
- Methyl 4-bromothiophene-2-carboxylate
- Synonyms
- methyl 4-chlorothiophene-2-carboxylate;Methyl 4-broMothiophene-2...;4-broMothiophene-2-carboxylate;methyl 4-chlorothiophene-2-carbo;4-Bromo-2-(carbomethoxy)thiophene;Methyl 4-bromothiophen-2-carboxylate;Methyl 4-bromothiophene-2-carboxylate;Methyl 4-bromothiophene-2-carboxylate 98%;4-bromothiophene-2-carboxylic acid methyl ester;4-Bromo-2-thiophenecarboxylic acid methyl ester
- CBNumber
- CB71504012
- Molecular Formula
- C6H5BrO2S
- Formula Weight
- 221.07
- MOL File
- 62224-16-2.mol
Methyl 4-bromothiophene-2-carboxylate Property
- Boiling point:
- 255 °C
- Density
- 1.662
- Flash point:
- 108 °C
- storage temp.
- 2-8°C(protect from light)
- form
- liquid
- color
- Colourless to light yellow
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M219330
- Product name
- Methyl4-Bromothiophene-2-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y6331
- Product name
- Methyl4-bromothiophene-2-carboxylate
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 6H66-9-04
- Product name
- Methyl 4-bromothiophene-2-carboxylate
- Purity
- 98%
- Packaging
- 10g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- Y6331
- Product name
- Methyl4-bromothiophene-2-carboxylate
- Packaging
- 5g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 112427
- Product name
- Methyl 4-bromothiophene-2-carboxylate
- Packaging
- 1g
- Price
- $143
- Updated
- 2021/12/16
Methyl 4-bromothiophene-2-carboxylate Chemical Properties,Usage,Production
Synthesis
16694-18-1
62224-16-2
b) General procedure for the synthesis of methyl 4-bromothiophene-2-carboxylate: 6.02 g (29.1 mmol) of 4-bromothiophene-2-carboxylic acid (prepared as in the previous procedure) was dissolved in 100 mL of anhydrous methanol under nitrogen protection and cooled to -20 °C. The reaction was completed by the addition of 2.55 mL (34.9 mmol) of thionyl chloride. 2.55 mL (34.9 mmol) of thionyl chloride was slowly added dropwise at a controlled acceleration rate to maintain the reaction temperature below -5 °C (dropwise addition was completed in about 8-10 min). After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour, followed by refluxing for 8 hours. Upon completion of the reaction, the mixture was cooled and concentrated in vacuum. The resulting 6.7 g of light amber oily product was purified by passing through a 150 g silica gel column, eluting with about 600 mL of dichloromethane (discarding the first 120 mL of the eluate which contained small amounts of impurities). Vacuum concentration gave the title compound, methyl 4-bromothiophene-2-carboxylate, as a colorless oil (6.11 g, 95% yield).1H-NMR (300 MHz, CDCl3) δ 7.69 (d, 1H, J = 1.5 Hz), 7.45 (d, 1H, J = 1.5 Hz), 3.90 (s, 3H).
References
[1] Patent: US2004/72871, 2004, A1. Location in patent: Page/Page column 29
[2] Patent: US2002/37915, 2002, A1
[3] Patent: US6291514, 2001, B1
[4] Patent: US2004/9995, 2004, A1
[5] Archiv der Pharmazie, 1998, vol. 331, # 12, p. 405 - 411
Methyl 4-bromothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-bromothiophene-2-carboxylate manufacturers
- Product
- Methyl 4-bromothiophene-2-carboxylate 62224-16-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-11-13
- Product
- Methyl 4-bromothiophene-2-carboxylate 62224-16-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25