2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE

Product Name: 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE
CAS No.: 60323-96-8
Chemical Name: 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE
Synonyms: Fampridine Impurity 171;Pyridine,2-chloro-5-methyl-4-nitro-;2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE;2-Chloro-5-Methyl-4-nitropyridine 1-oxide;2-chloro-5-Methyl-4-nitropyridine-1-o×ide;Pyridine,2-chloro-5-methyl-4-nitro-, 1-oxide;2-Chloro-5-methyl-4-nitropyridine N-oxide 97%;2-chloro-5-methyl-4-nitropyridin-1-ium-1-olate;2-chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium;2-chloro-5-Methyl-4-nitro-1$l^{5}-pyridin-1-one
CBNumber: CB71507972
Molecular Formula: C6H5ClN2O3
Formula Weight: 188.57
MOL File: 60323-96-8.mol

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2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE Property

Melting point:: 154-155 °C
Boiling point:: 399.8±37.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
pka: -2.38±0.10(Predicted)
form: solid
color: Light Yellow
InChI: InChI=1S/C6H5ClN2O3/c1-4-3-8(10)6(7)2-5(4)9(11)12/h2-3H,1H3
InChIKey: DXJQKWNJVPTPSK-UHFFFAOYSA-N
SMILES: C1(Cl)[N+]([O-])=CC(C)=C([N+]([O-])=O)C=1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C994228
Product name: 2-Chloro-5-methyl-4-nitropyridine-N-oxide
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4754-5-0A
Product name: 2-Chloro-5-methyl-4-nitropyridine N-oxide
Purity: 97%
Packaging: 5G
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: W7283
Product name: 2-Chloro-5-methyl-4-nitropyridineN-oxide
Packaging: 1g
Price: $203
Updated: 2021/12/16

AK Scientific

Product number: W7283
Product name: 2-Chloro-5-methyl-4-nitropyridineN-oxide
Packaging: 2g
Price: $317
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139617
Product name: 2-Chloro-5-methyl-4-nitropyridine 1-oxide
Packaging: 5G
Price: $395
Updated: 2021/12/16

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2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE Chemical Properties,Usage,Production

Synthesis

20173-49-3

60323-96-8

Step 2. Preparation of 2-chloro-5-methyl-4-nitropyridine-1-oxide: To a mixture of 165 mL of concentrated nitric acid and 209 mL of concentrated sulfuric acid, 56.4 g of 2-chloro-5-methylpyridine-1-oxide was slowly added. The reaction mixture was stirred at 100 °C for 2 h, subsequently cooled to room temperature and poured into ice water. The pH was adjusted to 2-3 with sodium carbonate solution. the resulting yellow solid was collected by filtration and washed with ice water. The filtrates were combined and extracted with hot chloroform. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 59.1 g of 2-chloro-5-methyl-4-nitropyridine-1-oxide in 80% yield. Mass spectral data: M + H = 189.

References

[1] Patent: WO2007/23105, 2007, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/203091, 2005, A1. Location in patent: Page/Page column 35; 44
[3] Heterocycles, 2009, vol. 78, # 11, p. 2811 - 2826
[4] Patent: US2016/362407, 2016, A1. Location in patent: Paragraph 0532-0533
[5] Patent: CN103193704, 2016, B. Location in patent: Paragraph 0025; 0030-0034

2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE Suppliers

China 92 India 7 United Kingdom 2 United States 7 Global 108

Jiangyin Jufeng Biotechnology Co., Ltd

Tel: 0519-89891966 13906113265
Email: 986329407@qq.com
Country: China
ProdList: 51
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Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
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Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
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Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
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T&W GROUP

Tel: 021-61551611 13296011611
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Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
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Shijiazhuang suchen Chemical Technology Co. LTD

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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
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ProdList: 9510
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Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
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View Lastest Price from 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE manufacturers

Shanghai UCHEM Inc.

Product: 2-Chloro-5-Methyl-4-Nitro-Pyridine 1-Oxide 60323-96-8
Price: US $70.00-555.00/g
Min. Order: 25g
Purity: 0.95
Supply Ability: 25kg
Release date: 2023-12-22

Dideu Industries Group Limited

Product: 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE 60323-96-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-23

Career Henan Chemical Co

Product: 2-chloro-5-methyl-4-nitropyridine-n-oxide 60323-96-8
Price: US $1.00/g
Min. Order: 1g
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-09

60323-96-8, 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDERelated Search:

2-methoxy-6-methyl-1-oxidopyridin-1-ium 3,5-DIBROMO-4-NITROPYRIDINE-N-OXIDE 2-Chloro-3-methyl-4-nitropyridine 1-oxide 2-Bromo-6-methyl-4-nitropyridin-1-oxide PYRIDINE, 5-BROMO-2-METHYL-4-NITRO-, 1-OXIDE 3-Methyl-4-nitropyridine N-Oxide 2-Chloropyridine-N-oxide 2-Chloro-4-nitropyridine 3-Methyl-4-nitropyridine 2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE 2-Chloro-4-nitropyridine 1-oxide

2-chloro-5-Methyl-4-nitro-1$l^{5}-pyridin-1-one

2-chloro-5-Methyl-4-nitropyridine-1-o×ide

2-chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium

Pyridine,2-chloro-5-methyl-4-nitro-, 1-oxide

Pyridine,2-chloro-5-methyl-4-nitro-

2-Chloro-5-Methyl-4-nitropyridine 1-oxide

2-Chloro-5-methyl-4-nitropyridine N-oxide 97%

2-chloro-5-methyl-4-nitropyridin-1-ium-1-olate

2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE

2-Chloro-5-methyl-4-nitropyridine nitrogen oxide

Fampridine Impurity 171

60323-96-8

Heterocycle-Pyridine series

Intermediate