2-Chloro-4-nitropyridine

Product Name: 2-Chloro-4-nitropyridine
CAS No.: 23056-36-2
Chemical Name: 2-Chloro-4-nitropyridine
Synonyms: 2-Chl;AURORA 23245;AKOS BBS-00001358;2-Chloro-4-nitropyri;OTAVA-BB BB7017520053;2-chloro-4-nitropyrine;2-Choro-4-nitropyridine;2-CHLORO-4-NITROPYRIDINE;4-Nitro-2-chloropyridine;oro-4-nitropyridine, 98%
CBNumber: CB2737111
Molecular Formula: C5H3ClN2O2
Formula Weight: 158.54
MOL File: 23056-36-2.mol

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2-Chloro-4-nitropyridine Property

Melting point:: 52-56 °C (lit.)
Boiling point:: 258.4±20.0 °C(Predicted)
Density: 1.489±0.06 g/cm3(Predicted)
Flash point:: 223 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -1.93±0.10(Predicted)
form: crystalline powder
color: Yellow
BRN: 120418
InChI: InChI=1S/C5H3ClN2O2/c6-5-3-4(8(9)10)1-2-7-5/h1-3H
InChIKey: LIEPVGBDUYKPLC-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC([N+]([O-])=O)=C1
CAS DataBase Reference: 23056-36-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 557390
Product name: 2-Chloro-4-nitropyridine
Purity: 97%
Packaging: 5g
Price: $56.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 557390
Product name: 2-Chloro-4-nitropyridine
Purity: 97%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: C2283
Product name: 2-Chloro-4-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: C2283
Product name: 2-Chloro-4-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $101
Updated: 2025/07/31

TCI Chemical

Product number: C2283
Product name: 2-Chloro-4-nitropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $343
Updated: 2025/07/31

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2-Chloro-4-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

2-Chloro-4-nitropyridine may be used to synthesize 2-chloro-4-ethoxypyridine and 4-thiophenoxypyridines.

Uses

2-Chloro-4-nitropyridine is used in the preparation of (thio)barbituric acid derivatives in the treatment of obesity related non-alcoholic fatty liver disease. As well it is used in the production of selective and potent MET Kinase inhibitors.

Synthesis

14432-16-7

23056-36-2

The general procedure for the synthesis of 2-chloro-4-nitropyridine-N-oxide from 2-chloro-4-nitropyridine-N-oxide is as follows: referring to the method of Example 17, phosphorus trichloride (4.2 mL, 48.7 mmol) was slowly added to a solution of anhydrous chloroform (25 mL) of 2-chloro-4-nitropyridine-N-oxide (1.70 g, 9.74 mmol) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained at this temperature for the reaction overnight. Upon completion of the reaction, the mixture was cooled to room temperature. The reaction solution was carefully poured into ice water and the pH was adjusted to 7-8 with alkali and subsequently washed with saturated sodium bicarbonate solution. The aqueous phase was extracted twice with chloroform, all organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and the organic phase was concentrated. Finally, the product was dried under high vacuum to give 2-chloro-4-nitropyridine (1.2 g, 78% yield) as a solid.

References

[1] Journal of Organic Chemistry, 2009, vol. 74, # 19, p. 7441 - 7448
[2] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 114
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 2674

2-Chloro-4-nitropyridine Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Phosphorus oxitrichloride Nitric acid Acetic acid Sulfuric acid 2-Chloropyridine

Preparation Products

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2-Chloro-4-nitropyridine Suppliers

Americas 1 Belgium 2 Canada 3 China 290 Europe 4 France 4 Germany 7 India 49 Japan 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 16 United States 55 Global 439

Shanghai Witofly Chemical Co. ,Ltd.

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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View Lastest Price from 2-Chloro-4-nitropyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-4-nitropyridine 23056-36-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Anhui Ruihan Technology Co., Ltd

Product: 2-Chloro-4-nitropyridine 23056-36-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-09-11

Honest Joy Holdings Limited

Product: 2-Chloro-4-nitropyridine 23056-36-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.5%
Supply Ability: 100 tons
Release date: 2022-01-26

23056-36-2, 2-Chloro-4-nitropyridineRelated Search:

2-Bromo-5-nitropyridine 4-Nitropyridine Pentachloropyridine 1-Chloro-3-nitrobenzene 2-Chloro-5-chloromethylpyridine 2-Chloro-3-hydroxypyridine Clopidol 2-Chloro-4-picoline 4-Chloronitrobenzene Difluorochloromethane 2-CHLORO-3-FLUORO-4-NITROPYRIDINE N-OXIDE 2,6-Dichloro-3-nitropyridine 2,6-DICHLORO-4-NITROPYRIDINE-N-OXIDE 2-CHLORO-4-NITROPYRIDINE-N-OXIDE,2-CHLORO-4-NITROPYRIDINE 1-OXIDE,2-Chloro-4-nitropyridine-N-oxide ,97% 4-Nitrobenzyl chloride 2,4-Dichloro-3-nitropyridine 4-Chloro-3-nitropyridine hydrochloride, 97+%,4-Chloro-3-nitropyridine hydrochloride, 98+%,4-CHLORO-3-NITROPYRIDINE HYDROCHLORIDE, 90+% 2-Nitrochlorobenzene

OTAVA-BB BB7017520053

2-CHLORO-4-NITROPYRIDINE

(2-CHLOROPYRIDIN-4-YL)(HYDROXY)OXOAMMONIUM

AURORA 23245

AKOS BBS-00001358

2-chloro-4-nitropyrine

2-Chloro-4-nitropyridine ,98%

2-Chloro-4-nitropyri

JRH-09201, 2-Chloro-4-nitropyridine, 97%

2-Choro-4-nitropyridine

2-Chl

4-Nitro-2-chloropyridine

2-Chloro-4-nitropyridine &gt

oro-4-nitropyridine, 98%

Pyridine, 2-chloro-4-nitro-

2,5-Difluoro-6-iodopyridine

2-Chloro-4-nitropyridine ISO 9001：2015 REACH

23056-36-2

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