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3-BROMO-5-CYANO (1H)INDAZOLE

Product Name
3-BROMO-5-CYANO (1H)INDAZOLE
CAS No.
395101-67-4
Chemical Name
3-BROMO-5-CYANO (1H)INDAZOLE
Synonyms
3-BROMO-5-CYANO (1H)INDAZOLE;3-Bromo-1H-indazol-5-carbonitrile;3-bromo-2H-indazole-5-carbonitrile;1H-Indazole-5-carbonitrile, 3-broMo-
CBNumber
CB71508025
Molecular Formula
C8H4BrN3
Formula Weight
222.04
MOL File
395101-67-4.mol
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3-BROMO-5-CYANO (1H)INDAZOLE Property

Boiling point:
425.3±25.0 °C(Predicted)
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
10.01±0.40(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B994110
Product name
3-Bromo-1H-indazole-5-carbonitrile
Packaging
100mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
Y5416
Product name
3-Bromo-1H-indazole-5-carbonitrile
Packaging
250mg
Price
$166
Updated
2021/12/16
AK Scientific
Product number
Y5416
Product name
3-Bromo-1H-indazole-5-carbonitrile
Packaging
1g
Price
$251
Updated
2021/12/16
Abosyn
Product number
21-2166
Product name
3-bromo-1H-indazole-5-carbonitrile
Purity
95%-98%
Packaging
1g
Price
$630
Updated
2021/12/16
Chemcia Scientific
Product number
BB20-8915A
Product name
3-Bromo-1H-indazole-5-carbonitrile
Purity
95%
Packaging
5G
Price
$725
Updated
2021/12/16
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3-BROMO-5-CYANO (1H)INDAZOLE Chemical Properties,Usage,Production

Synthesis

74626-47-4

395101-67-4

General procedure for the synthesis of 3-bromo-5-cyanoindazole from indazole-5-carbonitrile: 1H-indazole-5-carbonitrile (90 mg, 0.62 mmol) was dissolved in anhydrous N,N-dimethylformamide (DMF, 1 mL), and N-bromosuccinimide (NBS, 134 mg, 0.75 mmol) was added slowly at room temperature. The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent DMF was removed by distillation under reduced pressure. the residue was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate, deionized water and saturated saline in that order. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3-bromo-5-cyanoindazole (128 mg, 93% yield). Low resolution mass spectrometry (LRMS) showed m/z: 222/224 (Br isotope peak).

References

[1] Patent: EP2489663, 2012, A1. Location in patent: Paragraph 0215; 0216
[2] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0616; 0617
[3] Patent: US2002/103229, 2002, A1
[4] Patent: US2004/127536, 2004, A1
[5] Patent: US2005/9876, 2005, A1

3-BROMO-5-CYANO (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-5-CYANO (1H)INDAZOLE Suppliers

China 69 India 1 United States 4 Global 74
Pure Chemistry Scientific Inc.
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Sinova Inc.
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395101-67-4, 3-BROMO-5-CYANO (1H)INDAZOLERelated Search:

3-BROMO-5-METHYL (1H)INDAZOLE 1H-INDAZOLE-5-CARBONITRILE 3-BROMO-5-CYANO (1H)INDAZOLE

  • 3-BROMO-5-CYANO (1H)INDAZOLE
  • 1H-Indazole-5-carbonitrile, 3-broMo-
  • 3-bromo-2H-indazole-5-carbonitrile
  • 3-Bromo-1H-indazol-5-carbonitrile
  • 395101-67-4