5,7-Dichloroimidazo[4,5-b]pyridine
Uses- Product Name
- 5,7-Dichloroimidazo[4,5-b]pyridine
- CAS No.
- 24485-01-6
- Chemical Name
- 5,7-Dichloroimidazo[4,5-b]pyridine
- Synonyms
- Nsc264046;7-dichloro-1H-iMidazo[4;5,7-Dichloroimidazo[4,5-b]pyridine;5,7-dichloro-1H-imidazo[4,5-b]pyridine;Dichloro-1H-imidazolo [4,5-b] pyridine;5,7-dichloro-7aH-imidazo[4,5-b]pyridine;3H-Imidazo[4,5-b]pyridine, 5,7-dichloro-;1H-IMidazo[4,5-b]pyridine, 5,7-dichloro-;(1)5,7-dichloro-3H-imidazo[4,5-b]pyridine
- CBNumber
- CB71509244
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 24485-01-6.mol
5,7-Dichloroimidazo[4,5-b]pyridine Property
- Melting point:
- 273-274 °C
- Boiling point:
- 200.8±50.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.37±0.40(Predicted)
- Appearance
- Off-white to pink Solid
- InChI
- InChI=1S/C6H3Cl2N3/c7-3-1-4(8)11-6-5(3)9-2-10-6/h1-2H,(H,9,10,11)
- InChIKey
- IKJFWUNKUZVHGU-UHFFFAOYSA-N
- SMILES
- C12NC=NC1=C(Cl)C=C(Cl)N=2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D436853
- Product name
- 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FD139433
- Product name
- 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD139433
- Product name
- 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR931839
- Product name
- 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FD139433
- Product name
- 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
5,7-Dichloroimidazo[4,5-b]pyridine Chemical Properties,Usage,Production
Uses
5,7-Dichloro-1H-imidazo[4,5-B]pyridine is an important type of imidazopyridine compound with good antimicrobial and bactericidal effects.
Synthesis
14432-11-2
24485-01-6
General procedure for the synthesis of 5,7-dichloro-1H-imidazo[4,5-B]pyridine from 7-nitro-3H-imidazo[4,5-B]pyridine 4-oxide: 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (2.0 g, 11.04 mmol) was added batchwise to a mixed solution of ice-bath-cooled (0 °C) phosphoryl chloride (POCl3, 30 mL , 322 mmol) and N,N-dimethylformamide (DMF, 15 mL) in a mixed solution. Subsequently, the reaction mixture was heated to 120°C and maintained for 3 hours. After completion of the reaction, it was cooled to room temperature, slowly poured into ice water and neutralized with 5 M sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (3 × 75 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the crude product 5,7-dichloro-3H-imidazo[4,5-b]pyridine (1.86 g, 9.89 mmol, 90% yield), which was used directly in the next reaction without further purification. Mass spectrum (electrospray ionization) m/e 188 ([M+H]+). 1H NMR (400 MHz, methanol-d4) δ 8.45 (broad single peak, 1H), 7.46 (single peak, 1H).
References
[1] Patent: WO2013/95761, 2013, A1. Location in patent: Page/Page column 32; 33; 34
[2] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
5,7-Dichloroimidazo[4,5-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,7-Dichloroimidazo[4,5-b]pyridine manufacturers
- Product
- 3H-Imidazo[4,5-b]pyridine, 5,7-dichloro- 24485-01-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10