ChemicalBook > CAS DataBase List > 5,7-Dichloroimidazo[4,5-b]pyridine

5,7-Dichloroimidazo[4,5-b]pyridine

Uses

Product Name: 5,7-Dichloroimidazo[4,5-b]pyridine
CAS No.: 24485-01-6
Chemical Name: 5,7-Dichloroimidazo[4,5-b]pyridine
Synonyms: Nsc264046;7-dichloro-1H-iMidazo[4;5,7-Dichloroimidazo[4,5-b]pyridine;5,7-dichloro-1H-imidazo[4,5-b]pyridine;Dichloro-1H-imidazolo [4,5-b] pyridine;5,7-dichloro-7aH-imidazo[4,5-b]pyridine;3H-Imidazo[4,5-b]pyridine, 5,7-dichloro-;1H-IMidazo[4,5-b]pyridine, 5,7-dichloro-;(1)5,7-dichloro-3H-imidazo[4,5-b]pyridine
CBNumber: CB71509244
Molecular Formula: C6H3Cl2N3
Formula Weight: 188.01
MOL File: 24485-01-6.mol

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5,7-Dichloroimidazo[4,5-b]pyridine Property

Melting point:: 273-274 °C
Boiling point:: 200.8±50.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 5.37±0.40(Predicted)
Appearance: Off-white to pink Solid
InChI: InChI=1S/C6H3Cl2N3/c7-3-1-4(8)11-6-5(3)9-2-10-6/h1-2H,(H,9,10,11)
InChIKey: IKJFWUNKUZVHGU-UHFFFAOYSA-N
SMILES: C12NC=NC1=C(Cl)C=C(Cl)N=2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D436853
Product name: 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
Packaging: 500mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: J96722
Product name: 5,7-Dichloro-3H-imidazo[4,5-b]pyridine
Packaging: 1g
Price: $190
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-NF
Product name: 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
Purity: 96%
Packaging: 250mg
Price: $208
Updated: 2021/12/16

Apolloscientific

Product number: OR931839
Product name: 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
Purity: 96%
Packaging: 1g
Price: $235
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139433
Product name: 5,7-Dichloro-1H-imidazo[4,5-b]pyridine
Packaging: 1g
Price: $240
Updated: 2021/12/16

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5,7-Dichloroimidazo[4,5-b]pyridine Chemical Properties,Usage,Production

Uses

5,7-Dichloro-1H-imidazo[4,5-B]pyridine is an important type of imidazopyridine compound with good antimicrobial and bactericidal effects.

Synthesis

14432-11-2

24485-01-6

General procedure for the synthesis of 5,7-dichloro-1H-imidazo[4,5-B]pyridine from 7-nitro-3H-imidazo[4,5-B]pyridine 4-oxide: 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (2.0 g, 11.04 mmol) was added batchwise to a mixed solution of ice-bath-cooled (0 °C) phosphoryl chloride (POCl3, 30 mL , 322 mmol) and N,N-dimethylformamide (DMF, 15 mL) in a mixed solution. Subsequently, the reaction mixture was heated to 120°C and maintained for 3 hours. After completion of the reaction, it was cooled to room temperature, slowly poured into ice water and neutralized with 5 M sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (3 × 75 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the crude product 5,7-dichloro-3H-imidazo[4,5-b]pyridine (1.86 g, 9.89 mmol, 90% yield), which was used directly in the next reaction without further purification. Mass spectrum (electrospray ionization) m/e 188 ([M+H]+). 1H NMR (400 MHz, methanol-d4) δ 8.45 (broad single peak, 1H), 7.46 (single peak, 1H).

References

[1] Patent: WO2013/95761, 2013, A1. Location in patent: Page/Page column 32; 33; 34
[2] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760

5,7-Dichloroimidazo[4,5-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,7-Dichloroimidazo[4,5-b]pyridine manufacturers

Career Henan Chemical Co

Product: 3H-Imidazo[4,5-b]pyridine, 5,7-dichloro- 24485-01-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-10

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Heterocycle-Pyridine series