6-chloro-N-methyl-pyrimidine-4,5-diamine
- Product Name
- 6-chloro-N-methyl-pyrimidine-4,5-diamine
- CAS No.
- 52602-68-3
- Chemical Name
- 6-chloro-N-methyl-pyrimidine-4,5-diamine
- Synonyms
- 6-Chloro-4-methyl-4,5-diaminopyrimidine;6-Chloro-N4-methyl-4,5-pyrimidinediamine;6-chloro-N-methyl-pyrimidine-4,5-diamine;6-chloro-4-N-methylpyrimidine-4,5-diamine;5-Amino-6-chloro-4-(methylamino)pyrimidine;4-Chloro-5-amino-6-(methylamino)pyrimidine;4-(Methylamino)-5-amino-6-chloropyrimidine;4,5-Pyrimidinediamine, 6-chloro-N4-methyl-;6-chloro-N4-methylpyrimidine-4,5-diamine - [C86892];6-chloro-4-Methyl-4,5-dihydropyriMidine-4,5-diaMine
- CBNumber
- CB71518831
- Molecular Formula
- C5H7ClN4
- Formula Weight
- 158.59
- MOL File
- 52602-68-3.mol
6-chloro-N-methyl-pyrimidine-4,5-diamine Property
- Melting point:
- 62℃
- Density
- 1.447
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C384478
- Product name
- 6-Chloro-N4-methylpyrimidine-4,5-diamine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- W6733
- Product name
- 6-Chloro-N4-methyl-4,5-pyrimidinediamine
- Packaging
- 1g
- Price
- $252
- Updated
- 2021/12/16
- Product number
- 180241
- Product name
- 6-Chloro-N4-methylpyrimidine-4,5-diamine
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 180241
- Product name
- 6-Chloro-N4-methylpyrimidine-4,5-diamine
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- W6733
- Product name
- 6-Chloro-N4-methyl-4,5-pyrimidinediamine
- Packaging
- 5g
- Price
- $881
- Updated
- 2021/12/16
6-chloro-N-methyl-pyrimidine-4,5-diamine Chemical Properties,Usage,Production
Synthesis
5413-85-4
74-89-5
52602-68-3
General procedure for the synthesis of 6-chloro-4-methylpyrimidine-4,5-diamine from 4,6-dichloro-5-amino-pyrimidine and monomethylamine: a mixture of 5-amino-4,6-dichloropyrimidine (5,1.0 mmol), triethylamine (1.0 mmol), ethanol (4.3 mL), and monomethylamine (2.5 mmol) was placed in a steel cylinder and reacted for 3 hours by heating to 55°C. After completion of the reaction, the volatiles were removed under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent CHCl3-cC6H12-CH3OH (70:20:10), followed by recrystallization with EtOAc to afford the target compound, 6-chloro-4-methylpyrimidine-4,5-diamine (6), as a white solid (148 mg, 93% yield). The product characterization data were as follows: melting point 165-67 °C; 1H NMR (400 MHz, [D6]DMSO) δ 2.89 (d, J=4.4 Hz, 3H, CH3), 4.96 (br s, 2H, NH2), 6.86 (br q, J=4.4 Hz, 1H, NH), 7.75 (s, 1H, H-2); elemental analysis ( C5H7ClN4) is consistent with theoretical values.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 151, p. 199 - 213
[2] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 21
[3] Patent: US2010/298267, 2010, A1. Location in patent: Page/Page column 15
[4] Journal of Applied Chemistry, 1954, vol. 4, p. 72,74
[5] Collection of Czechoslovak Chemical Communications, 2011, vol. 76, # 11, p. 1379 - 1393
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