4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- Product Name
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- CAS No.
- 39065-95-7
- Chemical Name
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- Synonyms
- 4-(CHLORODIFLUOROMETHOXY)ANILINE;EOS-60713;TIMTEC-BB SBB000319;Pinacolborane Impurity 43;4-(Chlorodifluoromethoxy)aniline98%;4-(Chlorodifluoromethoxy)aniline95%;4-(chlorodifluoromethoxy)benzenamine;4-(Chlorodifluoromethoxy)aniline 98%;Benzenamine, 4-(chlorodifluoromethoxy)-;4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- CBNumber
- CB7152805
- Molecular Formula
- C7H6ClF2NO
- Formula Weight
- 193.58
- MOL File
- 39065-95-7.mol
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Property
- Boiling point:
- 231.9±40.0 °C(Predicted)
- Density
- 1.402±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Chloroform (Slightly), DMSO (Sparingly)
- pka
- 4.04±0.10(Predicted)
- form
- liquid
- color
- Pale yellow
- InChI
- InChI=1S/C7H6ClF2NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
- InChIKey
- QDTUQGSYECRXDO-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(OC(Cl)(F)F)C=C1
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-43-22
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- WGK 3
- Hazard Note
- Irritant
- HS Code
- 2921420090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C366070
- Product name
- 4-Chlorodifluoromethoxyaniline
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 4656-7-X3
- Product name
- 4-(Chlorodifluoromethoxy)aniline
- Purity
- 96%
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 4656-7-X3
- Product name
- 4-(Chlorodifluoromethoxy)aniline
- Purity
- 96%
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- 1935AQ
- Product name
- 4-(Chlorodifluoromethoxy)aniline
- Packaging
- 5g
- Price
- $585.2
- Updated
- 2021/12/16
- Product number
- 4656-7-X3
- Product name
- 4-(Chlorodifluoromethoxy)aniline
- Purity
- 96%
- Packaging
- 5G
- Price
- $615
- Updated
- 2021/12/16
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Chemical Properties,Usage,Production
Uses
4-Chlorodifluoromethoxyaniline has been used as a reactant for the preparation of arylphthalazines as a potent and orally bioavailable inhibitor of VEGFR-2.
Synthesis
40750-71-8
39065-95-7
General procedure for the synthesis of 4-(chlorodifluoromethoxy)aniline from 1-(chlorodifluoromethoxy)-4-nitrobenzene: 167 g of 1-(chlorodifluoromethoxy)-4-nitrobenzene was added to an autoclave, followed by the addition of 200 g of ethyl acetate and 15 g of nickel Nguyenne. After changing to a nitrogen atmosphere, hydrogen was introduced and the pressure in the autoclave was maintained at 2~3 MPa, and the reaction temperature was controlled at 30-40 °C. After the system pressure was stabilized and no longer decreased, the reaction was continued for 1 hour. Upon completion of the reaction, samples were taken and analyzed to ensure that the residual nitro compounds in the hydrogenation reaction solution were less than 0.5%. Subsequently, the catalyst was removed by filtration, and most of the solvent was firstly recovered by distillation at atmospheric pressure, and then purified by decompression distillation, finally 92.6 g of 4-(chlorodifluoromethoxy)aniline was obtained with a yield of 64.2%.
References
[1] Russian Journal of Organic Chemistry, 2002, vol. 38, # 2, p. 269 - 271
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Patent: CN104119238, 2016, B. Location in patent: Paragraph 0018; 0032; 0033; 0037; 0038
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE manufacturers
- Product
- 4-(Chlorodifluoromethoxy)aniline 39065-95-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE 39065-95-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-13
- Product
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE 39065-95-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16