3-Ethynylaniline

Product Name: 3-Ethynylaniline
CAS No.: 54060-30-9
Chemical Name: 3-Ethynylaniline
Synonyms: 3-ETHYNYLANILINE;3-ETHYNYL-PHENYLAMINE;3-EthynylbenzaMine;M-AMINOPHENYL ACETYLENE;SOLI-006;3-Ethynyl;Erlotinib-8;Erlotinib INT;3-Ethynlaniline;m-Ethnylaniline
CBNumber: CB4417819
Molecular Formula: C8H7N
Formula Weight: 117.15
MOL File: 54060-30-9.mol

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3-Ethynylaniline Property

Melting point:: 27°C
Boiling point:: 92-93 °C (2 mmHg)
Density: 1.04
refractive index: 1.614-1.616
Flash point:: 138 °F
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
pka: 3.67±0.10(Predicted)
form: Liquid
Specific Gravity: 1.12
color: Clear yellow to brown
Water Solubility: Insoluble in water.
BRN: 2935417
Stability:: Light Sensitive
InChI: 1S/C8H7N/c1-2-7-4-3-5-8(9)6-7/h1,3-6H,9H2
InChIKey: NNKQLUVBPJEUOR-UHFFFAOYSA-N
SMILES: Nc1cccc(c1)C#C
CAS DataBase Reference: 54060-30-9(CAS DataBase Reference)
NIST Chemistry Reference: M-aminophenylacetylene(54060-30-9)
EPA Substance Registry System: Benzenamine, 3-ethynyl- (54060-30-9)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39-36/37
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
TSCA: TSCA listed
HazardClass: 3
PackingGroup: Ⅲ
HS Code: 29214990
Storage Class: 3 - Flammable liquids
Hazard Classifications: Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 498289
Product name: 3-Ethynylaniline
Purity: ≥98%
Packaging: 5g
Price: $99.75
Updated: 2025/07/31

TCI Chemical

Product number: A1122
Product name: 3-Ethynylaniline
Purity: >98.0%(GC)
Packaging: 10g
Price: $105
Updated: 2021/12/16

TCI Chemical

Product number: A1122
Product name: 3-Ethynylaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $193
Updated: 2025/07/31

TCI Chemical

Product number: A1122
Product name: 3-Ethynylaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $65
Updated: 2025/07/31

TRC

Product number: E685070
Product name: 3-Ethynylaniline
Packaging: 10mg
Price: $55
Updated: 2021/12/16

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3-Ethynylaniline Chemical Properties,Usage,Production

Chemical Properties

Clear yellowish to brown liquid

Uses

Reagent in the preparation of a labelled metabolite of Erlotinib (E625000).

Uses

3-Aminophenylacetylene is used as a pharmaceutical intermediate.

Application

3-Ethynylaniline may be used in the synthesis of the following benzoxazine monomers: bis{4-[3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazin-6-yloxy)]phenyl}phenylphosphino-1-one, [3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazaperhydroin-6-yl)][3-(3-ethynylphenyl)(2H,4H-benzo[3,4-e]1,3-oxazin-6-yl)]phenylphosphino-1-one, and bis[3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazin-6-yl)oxy]phenylphosphino-1-one.
It may be used: To synthesize succin(m-ethynyl)dianilide and sebaco(m-ethynyl)dianilide. As a reagent in the multi-step synthesis of erlotinib hydrochloride. To prepare 3-(3-ethynylphenyl)-6-methyl-2H, 4H-benzo[e]1,3-oxazine. To prepare 3-[3-(4-acetylamino-benzyl)-[1,2,4]oxadiazol-5- yl]-N-(3-ethynyl-phenyl)-propionamide.

General Description

3-Ethynylaniline is a terminal alkyne that can be prepared by the reduction of 3-ethylnylnitrobenzene.

reaction suitability

reaction type: click chemistry

Synthesis

Starting with m-nitrocinnamic acid: First, it undergoes an addition reaction with liquid bromine in glacial acetic acid to generate 3-(3-nitro)phenyl-2,3-dibromopropionic acid; subsequently, it undergoes dehydrobromination and decarboxylation reactions under the action of an organic base (such as DBU) to generate the key intermediate m-nitrophenylacetylene; finally, the nitro group is reduced to an amino group using iron powder in an acidic aqueous ethanol solution to obtain the target product 3-Ethynylaniline.

3-Ethynylaniline Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Hydrazinium hydroxide solution Ethanol Iron chloride hexahydrate 3-NITROPHENYLACETYLENE Activated carbon

Preparation Products

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3-Ethynylaniline Suppliers

Americas 1 Belgium 4 Canada 1 China 487 Europe 4 Germany 6 India 67 Japan 4 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 15 United States 44 Global 638

Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 0519-85269522 15906111708
Fax: 013660798926
Email: sunlight68@126.com
Country: China
ProdList: 100
Advantage: 60

Biocompounds Pharmaceutical Inc.

Tel: 21-57687675
Fax: +86-21-57687169
Email: yanjie@biocompounds.com
Country: China
ProdList: 75
Advantage: 62

Shanghai Zhuorui Chemical Co.,Ltd.

Tel: 021-69180038
Fax: 0086-21-39177059
Email: zhuoruichem@163.com
Country: China
ProdList: 105
Advantage: 58

Wuhan kemike Biomedical Technology Co., Ltd

Tel: 027-87747081 18186681184
Email: 1344475572@qq.com
Country: China
ProdList: 7226
Advantage: 58

Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 0519-85195575 15861192208
Fax: 85195585
Email: 850305@sunkechem.com
Country: China
ProdList: 78
Advantage: 69

Gansu Songsheng Pharmaceutical Co. , Ltd.

Tel: 13705130158
Email: sales@unitechemical.com
Country: China
ProdList: 136
Advantage: 58

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai TBBMed Co.,Ltd

Tel: 021-50498136 13564881053
Fax: 021-50498136
Email: products@tbbmed.com
Country: China
ProdList: 184
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Changzhou Sunlight Pharmaceutical Co., Ltd

Tel: 519-83131668 15995063688
Fax: +86-519-83138041
Email: info@sunlightchem.com
Country: China
ProdList: 99
Advantage: 69

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View Lastest Price from 3-Ethynylaniline manufacturers

Hangzhou Verychem Science And Technology Co.Ltd

Product: 3-ethynylaniline 54060-30-9
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-05-12

Hebei Fengjia New Material Co., Ltd

Product: 3-AMinophenylacetylene 54060-30-9
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Aminophenylacetylene 54060-30-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-01

54060-30-9, 3-EthynylanilineRelated Search:

4-Aminobenzoic acid 2-BENZOYLACETANILIDE Aniline Methyl anthranilate EMERALDINE BASE POLYANILINE Diphenylamine 3-Aminobenzenesulfonamide Sulfanilic acid Acetylene Sulfanilamide p-Anisidine 2-Aminobenzaldehyde Diphenylacetylene Phenylacetylene N,N-Dimethylaniline Benzidine Metanilic acid 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

M-ETHYNYLANILINE

M-AMINOPHENYL ACETYLENE

3-AMINOPHENYLACETYLENE

3-ETHYNYLBENZENEAMINE

3-ETHYNYL-PHENYLAMINE

3-ETHYNYLANILINE

Benzenamine, 3-ethynyl-

3-ethynyl-benzenamin

(3-Ethynylphenyl)aMine-d4

(M-AMinophenyl)acetylene-d4

1-AMino-3-ethynylbenzene-d4

3-AMino-1-ethynylbenzene-d4

3-Ethynylaniline-d4

3-EthynylbenzenaMine-d4

M-Ethynylaniline-d4

3-EthynylbenzaMine

Erlotinib INT

Erlotinib iMpurity F

Erlotinib Impurity (3-Ethynylailine)

3-Ethynyl aniline or (3-aMinophenylacetylene)

3-AMinophenylacetylene(3-Ethynylaniline)

3-Ethynylailine Hydrochloride 2

RE-EXPORT OF 3-ETHYNYLANILINE

3-Ethynyl aniline (3-aminophenylacetylene)

3-AMINOPHENYLACETYLEN

3-Aminophenylacetylene98%

Benzenamine, 3-ethynyl- (9CI)

3-AMINOPHENYLACETYLENE 99+%

3-Ethynyl

3-ethynylbenzenamine

3-Ethynlaniline

1-Amino-3-ethynylbenzene

1-Ethynyl-3-aminobenzene

m-Ethnylaniline

3-Ethynylaniline ,98%

3-AMinophenylacetylene, 98% 25GR

3-AMinophenylacetylene, 98% 5GR

3-Ethynylaniline HC

3-Acetylenylaniline-d4

3-AMino-1-ethynylbenzene

3-aminophenylacetylene M-ETHYNYLANILINE

SOLI-006

Erlotinib Impurity 42

Erlotinib Hydrochloride Impurity P

Erlotinib Hydrochloride iMpurity 29

Erlotinib-8

3-Ethynylaniline &gt

3- Acetylene phenylamine

Erlotinib Impurity 47 (3-Ethynylailine)

High quality 3-Aminophenylacetylene

3-AMINOPHENYLACETYLENE (M-APA)54060-30-9

3-Aminophenylacetylene ISO 9001：2015 REACH

3-Ethynylaniline (Erlotinib Impurity)

Azilsartan medoxomil impurity250

Erlotinib impurities408

3- Aminophenylacetylene (3-APA)

3-Ethynylaniline - [E48307]

54060-30-9