ChemicalBook > CAS DataBase List > 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Product Name
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
CAS No.
179688-29-0
Chemical Name
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
Synonyms
6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one;in-4-one;CP-380736;PF-00520893;Erlotinib-14;ERLOTINIBINT-F;Erlotinib iMpurity E;Erlotinib impurities407;Erlotinib interMidiate V;6,7-Bis-(2-methoxyethoxy
CBNumber
CB5715899
Molecular Formula
C14H18N2O5
Formula Weight
294.3
MOL File
179688-29-0.mol
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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Property

Melting point:
185-189°C
Boiling point:
467.8±55.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: ≥10mg/mL
pka
1.35±0.20(Predicted)
form 
powder
color 
off-white to light tan
InChI
InChI=1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
InChIKey
PMQWTUWLIGJTQD-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(OCCOC)C(OCCOC)=C2)C(=O)NC=1
CAS DataBase Reference
179688-29-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0129
Product name
CP-380736
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0129
Product name
CP-380736
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
TCI Chemical
Product number
B4270
Product name
6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
B4270
Product name
6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$139
Updated
2025/07/31
TRC
Product number
M262635
Product name
6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one
Packaging
5mg
Price
$50
Updated
2021/12/16
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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intermediate in the synthesis of Erlotinib (E625000).

Biological Activity

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase th at activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

Synthesis

1208902-93-5

179688-29-0

GENERAL METHODS: To a solution of 6,7-dimethoxyquinazoline (200.0 mg, 1.05 mmol) in anhydrous ethanol (20 mL) was sequentially added 40% peracetic acid (1.0 mL, 5.26 mmol) and concentrated sulfuric acid (0.01 mL, 1.8 mmol). The reaction mixture was stirred in an oil bath at 60 °C for 4-12 h (the progress of the reaction was monitored by TLC). Upon completion of the reaction, the system was cooled to room temperature and residual peroxides were quenched by the addition of excess sodium bisulfite (541.8 mg, 5.26 mmol). After continued stirring for 20 min, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was washed with a solvent mixture of ethanol and petroleum ether (1:1, v/v) to afford 6,7-dimethoxyethoxyquinazolin-4-one (179.7 mg, 83% yield) as a light yellow solid with a melting point of >300°C. The crude product was washed with a solvent mixture of ethanol and petroleum ether (1:1, v/v) to afford 6,7-dimethoxyethoxyquinazolin-4-one as a light yellow solid.

References

[1] Synthetic Communications, 2014, vol. 44, # 3, p. 346 - 351
[2] Tetrahedron, 2010, vol. 66, # 4, p. 962 - 968

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Suppliers

Americas 1 Canada 2 China 404 Europe 1 Germany 1 India 71 Japan 1 Switzerland 1 United Kingdom 4 United States 23 Global 509
Shandong Kongfu Pharmaceutical Co
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0537-4442222 18854777456
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China
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21-57687675
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+86-21-57687169
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yanjie@biocompounds.com
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021-68900963 15618693615
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shandong XuanHong Pharmaceutical Technology Co.,Ltd
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sciencechem@163.com
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4006356688 18621169109
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86-21-61259102
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Chembest Research Laboratories Limited
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View Lastest Price from 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone manufacturers

Nanjing Fred Technology Co., Ltd
Product
6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one 179688-29-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%(HPLC)
Supply Ability
2000kg
Release date
2023-12-14
Hebei Ganmiao New material Technology Co., LTD
Product
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 179688-29-0
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06
Henan Fengda Chemical Co., Ltd
Product
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 179688-29-0
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

179688-29-0, 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinoneRelated Search:

Cefazolin sodium salt Quinoxaline Cefazolin 2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride 3-Ethynylaniline Erlotinib hydrochloride 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Ethyl 3,4-dihydroxybenzoate 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Impurity 20 Erlotinib Impurity 1 Erlotinib Impurity 3 DesMethyl Erlotinib Carboxylate Acid Erlotinib Impurity 35 4-CHLORO-7-(2-CHLORO-ETHOXY)-6-(2-METHOXY-ETHOXY)-QUINAZOLINE Ethyl 3,4-bis(2-methoxyethoxy)benzoate Erlotinib Hydrochloride iMpurity

  • 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE
  • Erlotinib LactaM IMpurity
  • 6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one
  • 6,7-bis-Methoxyethoxy-quinazolin-4-one
  • Erlotinib iMpurity E
  • ERLOTINIBINT-F
  • 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE
  • 6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one
  • 6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one
  • 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
  • 6,7-Bis-(2-Methoxyethoxy)quinazolin-4(3H)-one
  • 6,7-bis(2-methoxyethoxy)-quinazolin-4-one
  • CP-380736
  • PF-00520893
  • Erlotinib interMidiate V
  • 6,7-Di(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one
  • Erlotinib hydrochloride INT V
  • 6,7-bis(2-methoxyethoxy)quizolin-4(3H)-one
  • Erlotinib Hydrochloride iMpurity 26
  • Erlotinib-14
  • Erlotinib Hydrochloride iMpurity 13
  • 5-quinazolone, an intermediate of erlotinib
  • 6,7-Bis(2-methoxyethoxy)-3H-quinazo
  • 6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one &gt
  • 6,7-II (2-methoxyethoxy) quinazoline-4-ketone
  • 6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazoL
  • in-4-one
  • 4(3H)-Quinazolinone, 6,7-bis(2-methoxyethoxy)-
  • 6,7-Bis(2-methoxyethoxy)-4-hydroxyquinazoline
  • 6,7-Bis(2-methoxyethoxy)-4-quinazolinol
  • 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone ISO 9001：2015 REACH
  • 7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
  • 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one (Erlotinib Impurity)
  • Azilsartan medoxomil impurity249
  • Erlotinib impurities407
  • 6,7- dimethoxyquinazolin -4- one
  • 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone (Intermediate for Erlotinib)
  • 6,7-Dimethoxyethoxyquinoline-4-one
  • 6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazoline
  • 6,7-Bis-(2-methoxyethoxy
  • 6,7-Bis(2-methoxyethoxy)-4(1H)-quinazolinone
  • CP-380736, 10 mM in DMSO
  • 6,7-Bis(methoxyethoxy)quinazolinone
  • 7,8-dihydro-7,8-dimethoxy-7,8-dimethyl-[1,4]dioxino[2,3-g]quinazolin-4(3H)-one
  • 6,7-Bis-(2-methoxyethoxy)-quinazolin-4(3H)-one, 98%min
  • 6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quizolinone
  • 6,7-bis(2-methoxyethoxy)quinazoline-4-one
  • 179688-29-0
  • Erlotinib INTERMEDIATES
  • intermidiate of Erlotinib hydrochloride
  • Erlotinib
  • Aromatics
  • Heterocycles
  • Intermediates
  • Aromatics Compounds
  • Intermediate of erlotinib hydrochloride