6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Product Name: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
CAS No.: 179688-29-0
Chemical Name: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
Synonyms: 6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one;in-4-one;CP-380736;PF-00520893;Erlotinib-14;ERLOTINIBINT-F;Erlotinib iMpurity E;Erlotinib impurities407;Erlotinib interMidiate V;6,7-Bis-(2-methoxyethoxy
CBNumber: CB5715899
Molecular Formula: C14H18N2O5
Formula Weight: 294.3
MOL File: 179688-29-0.mol

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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Property

Melting point:: 185-189°C
Boiling point:: 467.8±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: ≥10mg/mL
pka: 1.35±0.20(Predicted)
form: powder
color: off-white to light tan
InChI: InChI=1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
InChIKey: PMQWTUWLIGJTQD-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(OCCOC)C(OCCOC)=C2)C(=O)NC=1
CAS DataBase Reference: 179688-29-0(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0129
Product name: CP-380736
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0129
Product name: CP-380736
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $404
Updated: 2024/03/01

TCI Chemical

Product number: B4270
Product name: 6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: B4270
Product name: 6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $139
Updated: 2025/07/31

TRC

Product number: M262635
Product name: 6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one
Packaging: 5mg
Price: $50
Updated: 2021/12/16

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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intermediate in the synthesis of Erlotinib (E625000).

Biological Activity

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase th at activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

Synthesis

1208902-93-5

179688-29-0

GENERAL METHODS: To a solution of 6,7-dimethoxyquinazoline (200.0 mg, 1.05 mmol) in anhydrous ethanol (20 mL) was sequentially added 40% peracetic acid (1.0 mL, 5.26 mmol) and concentrated sulfuric acid (0.01 mL, 1.8 mmol). The reaction mixture was stirred in an oil bath at 60 °C for 4-12 h (the progress of the reaction was monitored by TLC). Upon completion of the reaction, the system was cooled to room temperature and residual peroxides were quenched by the addition of excess sodium bisulfite (541.8 mg, 5.26 mmol). After continued stirring for 20 min, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was washed with a solvent mixture of ethanol and petroleum ether (1:1, v/v) to afford 6,7-dimethoxyethoxyquinazolin-4-one (179.7 mg, 83% yield) as a light yellow solid with a melting point of >300°C. The crude product was washed with a solvent mixture of ethanol and petroleum ether (1:1, v/v) to afford 6,7-dimethoxyethoxyquinazolin-4-one as a light yellow solid.

References

[1] Synthetic Communications, 2014, vol. 44, # 3, p. 346 - 351
[2] Tetrahedron, 2010, vol. 66, # 4, p. 962 - 968

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Suppliers

Americas 1 Canada 2 China 404 Europe 1 Germany 1 India 71 Japan 1 Switzerland 1 United Kingdom 4 United States 23 Global 509

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

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View Lastest Price from 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone manufacturers

Nanjing Fred Technology Co., Ltd

Product: 6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one 179688-29-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%(HPLC)
Supply Ability: 2000kg
Release date: 2023-12-14

Hebei Ganmiao New material Technology Co., LTD

Product: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 179688-29-0
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-06

Henan Fengda Chemical Co., Ltd

Product: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 179688-29-0
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

179688-29-0, 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinoneRelated Search:

Cefazolin sodium salt Quinoxaline Cefazolin 2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride 3-Ethynylaniline Erlotinib hydrochloride 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Ethyl 3,4-dihydroxybenzoate 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Impurity 20 Erlotinib Impurity 1 Erlotinib Impurity 3 DesMethyl Erlotinib Carboxylate Acid Erlotinib Impurity 35 4-CHLORO-7-(2-CHLORO-ETHOXY)-6-(2-METHOXY-ETHOXY)-QUINAZOLINE Ethyl 3,4-bis(2-methoxyethoxy)benzoate Erlotinib Hydrochloride iMpurity

6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE

Erlotinib LactaM IMpurity

6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one

6,7-bis-Methoxyethoxy-quinazolin-4-one

Erlotinib iMpurity E

ERLOTINIBINT-F

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE

6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one

6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

6,7-Bis-(2-Methoxyethoxy)quinazolin-4(3H)-one

6,7-bis(2-methoxyethoxy)-quinazolin-4-one

CP-380736

PF-00520893

Erlotinib interMidiate V

6,7-Di(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one

Erlotinib hydrochloride INT V

6,7-bis(2-methoxyethoxy)quizolin-4(3H)-one

Erlotinib Hydrochloride iMpurity 26

Erlotinib-14

Erlotinib Hydrochloride iMpurity 13

5-quinazolone, an intermediate of erlotinib

6,7-Bis(2-methoxyethoxy)-3H-quinazo

6,7-Bis(2-methoxyethoxy)-3H-quinazolin-4-one &gt

6,7-II (2-methoxyethoxy) quinazoline-4-ketone

6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazoL

in-4-one

4(3H)-Quinazolinone, 6,7-bis(2-methoxyethoxy)-

6,7-Bis(2-methoxyethoxy)-4-hydroxyquinazoline

6,7-Bis(2-methoxyethoxy)-4-quinazolinol

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone ISO 9001：2015 REACH

7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one (Erlotinib Impurity)

Azilsartan medoxomil impurity249

Erlotinib impurities407

6,7- dimethoxyquinazolin -4- one

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone (Intermediate for Erlotinib)

6,7-Dimethoxyethoxyquinoline-4-one

6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazoline

6,7-Bis-(2-methoxyethoxy

6,7-Bis(2-methoxyethoxy)-4(1H)-quinazolinone

CP-380736, 10 mM in DMSO

6,7-Bis(methoxyethoxy)quinazolinone

7,8-dihydro-7,8-dimethoxy-7,8-dimethyl-[1,4]dioxino[2,3-g]quinazolin-4(3H)-one

6,7-Bis-(2-methoxyethoxy)-quinazolin-4(3H)-one, 98%min

6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quizolinone

6,7-bis(2-methoxyethoxy)quinazoline-4-one

179688-29-0

Erlotinib INTERMEDIATES

intermidiate of Erlotinib hydrochloride

Erlotinib

Aromatics

Heterocycles

Intermediates

Aromatics Compounds

Intermediate of erlotinib hydrochloride