Ethyl 3,4-bis(2-methoxyethoxy)benzoate
- Product Name
- Ethyl 3,4-bis(2-methoxyethoxy)benzoate
- CAS No.
- 183322-16-9
- Chemical Name
- Ethyl 3,4-bis(2-methoxyethoxy)benzoate
- Synonyms
- ERLOTINIBINT-B;Erlotinib interMediate II;Ethyl 3,4-bis(2-methoxyethoxy);3,4-bis(2-methoxyethoxy)benzoate;Erlotinib Hydrochloride iMpurity 30;Thyl3,4-bis(2-methoxyethoxy)benzoate;Ethyl 3,4-bis(2-methoxyethoxy)benzoate;3,-bis(2-methoxyethoxy)-benzoic acid ethyl ester;3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester;Benzoic acid,3,4-bis(2-Methoxyethoxy)-, ethyl ester
- CBNumber
- CB21504002
- Molecular Formula
- C15H22O6
- Formula Weight
- 298.33
- MOL File
- 183322-16-9.mol
Ethyl 3,4-bis(2-methoxyethoxy)benzoate Property
- Melting point:
- 55-58 °C
- Boiling point:
- 401.7±45.0 °C(Predicted)
- Density
- 1.102
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C15H22O6/c1-4-19-15(16)12-5-6-13(20-9-7-17-2)14(11-12)21-10-8-18-3/h5-6,11H,4,7-10H2,1-3H3
- InChIKey
- VGFZRAVMWXHEJB-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C1=CC=C(OCCOC)C(OCCOC)=C1
Safety
- HS Code
- 2916.31.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E1186
- Product name
- Ethyl 3,4-Bis(2-methoxyethoxy)benzoate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2026/03/19
- Product number
- E1186
- Product name
- Ethyl 3,4-Bis(2-methoxyethoxy)benzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $65
- Updated
- 2026/03/19
- Product number
- M292990
- Product name
- 3,4-bis(2-Methoxyethoxy)benzoicAcidEthylEster
- Packaging
- 25g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- IB31255
- Product name
- 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J11300
- Product name
- ErlotinibImpurity17
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
Ethyl 3,4-bis(2-methoxyethoxy)benzoate Chemical Properties,Usage,Production
Uses
3,4-bis(2-Methoxyethoxy)benzoic Acid Ethyl Ester is a compound used in the synthesis of Erlotinib (E625008), a cancer treatment medicine.
Synthesis
3943-89-3
6482-24-2
183322-16-9
(3) Preparation of ethyl 3,4-bis(2-methoxyethoxy)benzoate 13: Ethyl 3,4-dihydroxybenzoate 12 (5 g, 27.45 mmol) was placed in a 250 mL two-necked flask and acetone (100 mL), potassium carbonate (9.48 g, 68.63 mmol), potassium iodide (0.5 g) and 2-bromoethyl methyl ether ( 7.84 mL, 82.35 mmol). The reaction mixture was heated to reflux at 60 °C for 19 hours. Upon completion of the reaction, the reaction solution was cooled to 5 °C and stirred for 30 min, followed by filtration and concentration to dryness. The resulting solid was dried by oil pumping for 22 h to give the khaki colored solid product 13 (8.19 g, 100% yield).1H-NMR (CDCl3) data: δ 1.32 (t, 3H, J = 7Hz), 3.41 (s, 6H), 3.76 (m, 4H), 4.15 (m, 4H), 4.29 (q, 2H, J = 7Hz), 6.85 (d, 1H, J = 8.4Hz), 7.53 (dd, 1H, J = 8.4Hz, J = 2.3Hz), 7.63 (dd, 1H, J = 8.4Hz, J = 2.3Hz).
References
[1] Patent: US2010/267949, 2010, A1. Location in patent: Page/Page column 6
[2] Patent: EP1614676, 2006, A1. Location in patent: Page/Page column 194
[3] Patent: EP2163546, 2016, B1. Location in patent: Paragraph 0125
[4] European Journal of Medicinal Chemistry, 2008, vol. 43, # 7, p. 1478 - 1488
[5] Chemistry - A European Journal, 2015, vol. 21, # 41, p. 14342 - 14346
Ethyl 3,4-bis(2-methoxyethoxy)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 3,4-bis(2-methoxyethoxy)benzoate manufacturers
- Product
- Ethyl 3,4-bis(2-methoxyethoxy)benzoate 183322-16-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24