(+)-Ledene

Product Name: (+)-Ledene
CAS No.: 21747-46-6
Chemical Name: (+)-Ledene
Synonyms: (+)-LEDENE;(+)-Ledene;Viridflorene;Varidiflorene;Einecs 244-565-3;LEDENE, (+)-(RG);Guaiazulene Impurity 4;95.0% (sum of enantiomers, GC);(+)-LEDENE 95+% MIXTURE OF ISOMERS;(+)-Ledene >=95.0% (sum of enantiomers, GC)
CBNumber: CB7153554
Molecular Formula: C15H24
Formula Weight: 204.35
MOL File: 21747-46-6.mol

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(+)-Ledene Property

Melting point:: 269°C
Boiling point:: 268-270 °C (lit.)
Density: 0.927 g/mL at 20 °C (lit.)
refractive index: n20/D 1.504
storage temp.: Refrigerator
solubility: Chloroform (Sparingly), Ethanol (Slightly)
form: Oil
color: Colourless
optical activity: [α]20/D +68±2°, c = 10% in ethanol
BRN: 2554786
LogP: 6.447 (est)

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Safety

Safety Statements: 23-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 61770
Product name: (+)-Ledene
Purity: ≥95.0% (sum of enantiomers, GC)
Packaging: 250mg
Price: $367
Updated: 2023/06/20

TRC

Product number: L320070
Product name: (+)-Ledene
Packaging: 5mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015052
Product name: (+)-LEDENE
Purity: 95.00%
Packaging: 250MG
Price: $839.22
Updated: 2021/12/16

AHH

Product number: MT-16357
Product name: (+)-Ledene
Purity: 96%
Packaging: 1g
Price: $418
Updated: 2021/12/16

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(+)-Ledene Chemical Properties,Usage,Production

Description

(+)-Ledene, also called leden or viridiflorene, is an organic compound that belongs to the group of 5, 10-cycloaromadendrane sesquiterpenoids. These compounds are derived from the aromadendrane skeleton through a cyclization reaction between carbon atoms 5 and 10. (+)-Ledene is mainly found in saliva and is considered to have low solubility in water and a relatively neutral nature. In cellular environments, (+)-ledene is predominantly present in the cell membrane (predicted based on logP) and cytoplasm.

Uses

(+)-Ledene is an essential oil that is synthesized by viridiflorene synthase. It has been studied as an antioxidant, antimicrobial, antibiofilm and to treat various cancers.

Definition

ChEBI: Viridiflorene is a carbotricyclic sesquiterpene obtained from several natural sources, including Australian Tea Tree oil (Melaleuca alternifolia.) It is a sesquiterpene and a carbotricyclic compound.

General Description

(+)-Ledene is a naturally occurring sesquiterpene that can be prepared from (+)-aromadendrene via isomerization.

References

[1] DUC N. TRAN Prof.??Dr. N C. Biomimetic Synthesis of (+)-Ledene, (+)-Viridiflorol, (?)-Palustrol, (+)-Spathulenol, and Psiguadial A, C, and D via the Platform Terpene (+)-Bicyclogermacrene[J]. Chemistry - A European Journal, 2014. DOI:10.1002/chem.201403082.
[2] S. L. GWALTNEY K. J S S T Sakata. Bridged to Fused Ring Interchange. Methodology for the Construction of Fused Cycloheptanes and Cyclooctanes. Total Syntheses of Ledol, Ledene, and Compressanolide[J]. The Journal of Organic Chemistry, 1996. DOI:10.1021/jo961005a.

(+)-Ledene Preparation Products And Raw materials

Raw materials

Preparation Products

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21747-46-6, (+)-LedeneRelated Search:

CYCLOOCTENE (+)-Ledene CIS-1,2-DIMETHYLCYCLOPROPANE ETHYLIDENECYCLOPENTANE CYCLOHEPTENE 3-METHYLCYCLOOCTENE 1-METHYL-1-CYCLOHEPTENE 1-METHYL-1-CYCLOOCTENE METHYLENECYCLOPENTANE (1,2-DIMETHYLPROPYL)CYCLOPROPANE TRANS-1,2-DIMETHYLCYCLOPROPANE 2,3-DIMETHYL-2-OCTENE CIS-1-ETHYL-2-METHYLCYCLOPROPANE CIS-1,2-DIETHYLCYCLOPROPANE 2,3-DIMETHYL-2-HEPTENE (1-METHYLBUTYL)CYCLOPROPANE SEC-BUTYLCYCLOPROPANE

1,1,4,7-Tetramethyl-1a,2,3,5,6,7,7a,7b-octahydro-1H-cyclopropa[e]azulene

1H-Cycloprop[e]azulene, 1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-, [1aR-(1aalpha,7alpha,7abeta,7balpha)]-

Varidiflorene

Viridflorene

(+)-Ledene >=95.0% (sum of enantiomers, GC)

[1aR-(1aalpha,7alpha,7abeta,7balpha)]-1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-1H-cycloprop[e]azulene

(1S,2R,3R,11R)-3,3,7,11-TETRAMETHYL-TRICYCLO[6.3.0.0(2.4)]UNDEC-7-ENE

(+)-LEDENE

(+)-LEDENE 95+% MIXTURE OF ISOMERS

(1aR)-1a,2,3,5,6,7,7aα,7bβ-Octahydro-1,1,4,7β-tetramethyl-1H-cycloprop[e]azulene

(1aR)-1aβ,2,3,5,6,7,7aα,7bβ-Octahydro-1,1,4,7β-tetramethyl-1H-cyclopropa[e]azulene

(1Ar-(1aalpha,7alpha,7abeta,7balpha))-1A,2,3,5,6,7,7A,7B-octahydro-1,1,4,7-tetramethyl-1H-cycloprop(E)azulene

Einecs 244-565-3

LEDENE, (+)-(RG)

(1aS,7S,7aS,7bS)-1,1,4,7-tetramethyl-1a,2,3,5,6,7,7a,7b-octahydrocyclopropa[e]azulene

1H-Cycloprop[e]azulene, 1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-, (1aR,7R,7aS,7bR)-

95.0% (sum of enantiomers, GC)

(+)-Ledene

Guaiazulene Impurity 4

21747-46-6

Complex Molecules

Asymmetric Synthesis

Chiral Building Blocks