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(+)-Ledene

Product Name
(+)-Ledene
CAS No.
21747-46-6
Chemical Name
(+)-Ledene
Synonyms
(+)-LEDENE;(+)-Ledene;Viridflorene;Varidiflorene;Einecs 244-565-3;LEDENE, (+)-(RG);Guaiazulene Impurity 4;95.0% (sum of enantiomers, GC);(+)-LEDENE 95+% MIXTURE OF ISOMERS;(+)-Ledene >=95.0% (sum of enantiomers, GC)
CBNumber
CB7153554
Molecular Formula
C15H24
Formula Weight
204.35
MOL File
21747-46-6.mol
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(+)-Ledene Property

Melting point:
269°C
Boiling point:
268-270 °C (lit.)
Density 
0.927 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.504
storage temp. 
Refrigerator
solubility 
Chloroform (Sparingly), Ethanol (Slightly)
form 
Oil
color 
Colourless
optical activity
[α]20/D +68±2°, c = 10% in ethanol
BRN 
2554786
LogP
6.447 (est)
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Safety

Safety Statements 
23-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
61770
Product name
(+)-Ledene
Purity
≥95.0% (sum of enantiomers, GC)
Packaging
250mg
Price
$367
Updated
2023/06/20
TRC
Product number
L320070
Product name
(+)-Ledene
Packaging
5mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0015052
Product name
(+)-LEDENE
Purity
95.00%
Packaging
250MG
Price
$839.22
Updated
2021/12/16
AHH
Product number
MT-16357
Product name
(+)-Ledene
Purity
96%
Packaging
1g
Price
$418
Updated
2021/12/16
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(+)-Ledene Chemical Properties,Usage,Production

Description

(+)-Ledene, also called leden or viridiflorene, is an organic compound that belongs to the group of 5, 10-cycloaromadendrane sesquiterpenoids. These compounds are derived from the aromadendrane skeleton through a cyclization reaction between carbon atoms 5 and 10. (+)-Ledene is mainly found in saliva and is considered to have low solubility in water and a relatively neutral nature. In cellular environments, (+)-ledene is predominantly present in the cell membrane (predicted based on logP) and cytoplasm.

Uses

(+)-Ledene is an essential oil that is synthesized by viridiflorene synthase. It has been studied as an antioxidant, antimicrobial, antibiofilm and to treat various cancers.

Definition

ChEBI: Viridiflorene is a carbotricyclic sesquiterpene obtained from several natural sources, including Australian Tea Tree oil (Melaleuca alternifolia.) It is a sesquiterpene and a carbotricyclic compound.

General Description

(+)-Ledene is a naturally occurring sesquiterpene that can be prepared from (+)-aromadendrene via isomerization.

References

[1] DUC N. TRAN   Prof.??Dr. N C. Biomimetic Synthesis of (+)-Ledene, (+)-Viridiflorol, (?)-Palustrol, (+)-Spathulenol, and Psiguadial A, C, and D via the Platform Terpene (+)-Bicyclogermacrene[J]. Chemistry - A European Journal, 2014. DOI:10.1002/chem.201403082.
[2] S. L. GWALTNEY   K. J S  S T Sakata. Bridged to Fused Ring Interchange. Methodology for the Construction of Fused Cycloheptanes and Cyclooctanes. Total Syntheses of Ledol, Ledene, and Compressanolide[J]. The Journal of Organic Chemistry, 1996. DOI:10.1021/jo961005a.

(+)-Ledene Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-Ledene Suppliers

China 33 France 1 Germany 2 South Korea 1 Switzerland 1 United Kingdom 3 United States 8 Global 49
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75

21747-46-6, (+)-LedeneRelated Search:

CYCLOOCTENE (+)-Ledene CIS-1,2-DIMETHYLCYCLOPROPANE ETHYLIDENECYCLOPENTANE CYCLOHEPTENE 3-METHYLCYCLOOCTENE 1-METHYL-1-CYCLOHEPTENE 1-METHYL-1-CYCLOOCTENE METHYLENECYCLOPENTANE (1,2-DIMETHYLPROPYL)CYCLOPROPANE TRANS-1,2-DIMETHYLCYCLOPROPANE 2,3-DIMETHYL-2-OCTENE CIS-1-ETHYL-2-METHYLCYCLOPROPANE CIS-1,2-DIETHYLCYCLOPROPANE 2,3-DIMETHYL-2-HEPTENE (1-METHYLBUTYL)CYCLOPROPANE SEC-BUTYLCYCLOPROPANE

  • 1,1,4,7-Tetramethyl-1a,2,3,5,6,7,7a,7b-octahydro-1H-cyclopropa[e]azulene
  • 1H-Cycloprop[e]azulene, 1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-, [1aR-(1aalpha,7alpha,7abeta,7balpha)]-
  • Varidiflorene
  • Viridflorene
  • (+)-Ledene >=95.0% (sum of enantiomers, GC)
  • [1aR-(1aalpha,7alpha,7abeta,7balpha)]-1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-1H-cycloprop[e]azulene
  • (1S,2R,3R,11R)-3,3,7,11-TETRAMETHYL-TRICYCLO[6.3.0.0(2.4)]UNDEC-7-ENE
  • (+)-LEDENE
  • (+)-LEDENE 95+% MIXTURE OF ISOMERS
  • (1aR)-1a,2,3,5,6,7,7aα,7bβ-Octahydro-1,1,4,7β-tetramethyl-1H-cycloprop[e]azulene
  • (1aR)-1aβ,2,3,5,6,7,7aα,7bβ-Octahydro-1,1,4,7β-tetramethyl-1H-cyclopropa[e]azulene
  • (1Ar-(1aalpha,7alpha,7abeta,7balpha))-1A,2,3,5,6,7,7A,7B-octahydro-1,1,4,7-tetramethyl-1H-cycloprop(E)azulene
  • Einecs 244-565-3
  • LEDENE, (+)-(RG)
  • (1aS,7S,7aS,7bS)-1,1,4,7-tetramethyl-1a,2,3,5,6,7,7a,7b-octahydrocyclopropa[e]azulene
  • 1H-Cycloprop[e]azulene, 1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-, (1aR,7R,7aS,7bR)-
  • 95.0% (sum of enantiomers, GC)
  • (+)-Ledene
  • Guaiazulene Impurity 4
  • 21747-46-6
  • Complex Molecules
  • Asymmetric Synthesis
  • Chiral Building Blocks