2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Product Name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
CAS No.: 152628-02-9
Chemical Name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
Synonyms: 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole;2-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE;Telmisartan EP Impurity A;2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole;Telmisartan RC-A;Bis-Benzoimidazole;TelMisartan IMpurity A;Telmisartan Impurity 2;Telmisartan impurities1035;Telmisartan Impurity A（EP）
CBNumber: CB7153796
Molecular Formula: C19H20N4
Formula Weight: 304.39
MOL File: 152628-02-9.mol

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2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Property

Melting point:: 130-135 °C(Solv: tetrahydrofuran (109-99-9))
Boiling point:: 584.8±52.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Powder
pka: 11.86±0.30(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C19H20N4/c1-4-7-17-20-15-11-13(10-12(2)18(15)22-17)19-21-14-8-5-6-9-16(14)23(19)3/h5-6,8-11H,4,7H2,1-3H3,(H,20,22)
InChIKey: ILXRSCZVHSZGCS-UHFFFAOYSA-N
SMILES: C1(C2=CC(C)=C3NC(CCC)=NC3=C2)N(C)C2=CC=CC=C2N=1
LogP: 3.49 at 20℃ and pH6
CAS DataBase Reference: 152628-02-9(CAS DataBase Reference)

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Safety

HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5079
Product name: 1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole
Packaging: 5G
Price: $95
Updated: 2025/07/31

TCI Chemical

Product number: D5079
Product name: 1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole
Packaging: 25G
Price: $328
Updated: 2025/07/31

TRC

Product number: P838280
Product name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole
Packaging: 50mg
Price: $100
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000177
Product name: 2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOLE-2-YL)BENZIMIDAZOLE
Purity: 95.00%
Packaging: 1G
Price: $143.85
Updated: 2021/12/16

Matrix Scientific

Product number: 072121
Product name: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
Purity: 95+%
Packaging: 1g
Price: $20
Updated: 2021/12/16

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2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Grey Powder

Uses

An impurity found in Telmisartan (T017000).

Synthesis

25148-68-9

152628-03-0

152628-02-9

General procedure for the synthesis of 1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-dibenzo[d]imidazole from N-methyl-o-phenylenediamine hydrochloride and 2-n-propyl-4-methyl-6-carboxybenzimidazole: Suspension of 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid (50 g) in poly(phosphoric acid) (300 g) was heated to 70-75 °C and maintained for 30 minutes. Subsequently, N-methylphthalimide dihydrochloride (45 g) was added in batches for 2 hours and the reaction was continued at 70-75°C for 1 hour. Next, the temperature of the reaction mixture was raised to 130-135°C and maintained for 10 hours. Upon completion of the reaction, the mixture was cooled to 70°C and water (600 mL) was slowly added to maintain the temperature at 60-90°C. Cooling was continued to 30 °C and the pH was adjusted to 8.0-8.5 with an aqueous ammonia solution.Subsequently, the reaction mixture was heated to 50-55 °C and held for 1 h. The solids were collected by filtration and the wet filter cake was washed with hot water (200 ml). The wet filter cake was suspended in water (900 mL), heated to 50-55 °C, stirred for 1 h and filtered, then washed with hot water (100 mL), and the wet filter cake was dried at 70-75 °C to constant weight. The dried product was suspended in methanol (260 mL), heated to 45-50 °C, activated carbon (6.5 g) was added and stirred for 30 min. Insoluble material was removed by filtration through a Hyflo bed, the bed was washed with hot methanol (60 mL), the filtrates were combined and cooled to 25 °C. Water (160 mL) was slowly added to the filtrate at 25-35°C, heated to reflux temperature and held for 1 hour. The reaction mixture was cooled to 0-5 °C and maintained for 2 h. The resulting solid was filtered, washed with methanol (60 mL) and the wet filter cake was dried at 70-75 °C to constant weight to give 54 g of 4-methyl-6-(1-methylbenzimidazol-2-yl)-2- n-propyl-1H-benzimidazole (77.4% yield), with a water content of 5.85% as determined by KF.

References

[1] Patent: WO2007/10558, 2007, A1. Location in patent: Page/Page column 5; 10-11
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 161 - 178

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Suppliers

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View Lastest Price from 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Baoji Guokang Healthchem Co., Ltd.

Product: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price: US $115.00/Kg/Bag
Min. Order: 25KG
Purity: 98%
Supply Ability: 1-10mt
Release date: 2021-06-03

152628-02-9, 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazoleRelated Search:

Telmisartan tert-Butyl Ester Kresoxim-methyl Cyclopropyl methyl ketone Methyl salicylate Propyl gallate Isopropyl alcohol Benzimidazole Tribenuron methyl ALLYL METHYL ETHER Propyl butyrate N,N-Dimethylallylamine 3-Methyl-2-butanone Telmisartan Telmisartan sodium 4-Bromomethyl-2-cyanobiphenyl Telmisartan impurity Thiophanate-methyl TELMISARTAN-D3

1,7'-diMethyl-2'-propyl-1H,3'H-

TelMisartan IMpurity A(2-n-propyl-4-Methyl-6-(1-MethylbenziMidazole-2-yl)benziMidazole)

TelMisartan IMpurity A

TelMisartan Related CoMpound A

4-Methyl-2-propyl-6-benziMidazolecarboxylic Acid, 97+%

2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Imp. A:2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazole

1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole

NA###2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

1H-BENZIMIDAZOLE 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)

2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE(INTERMEDIATE OF TELMISARTAN)

1H-Benzimidazole-2-N-Propyl-4-Methyl-6-(1-Methylbenzimidiazole-2-Yl)

2-N-Propyl-4-Methyl-6-(1-MethylBenzimidazole-2-Yl)-Benzimidazole[TelmisartanIntermediates]

2-N-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-BenzimidazoleTelmisartanMethylEster

Bis-Benzoimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)–benzimidazole

Telmisartan EP Impurity A

4,4''-DIMETHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE

7''-METHYL-2''-PROPYL-1H,3''H-2,5''-BIBENZO[D]IMIDAZOLE

1,4''-DIMETHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE

4''-METHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE

2-N-Propyl-4-Methyl-6-(1-Methy

Bis-Benzoimidazole

2,5'-bi-1H-Benzimidazole,1,7'-dimethyl-2'-propyl-

2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-YI)Benzimidazole

7-Methyl-5-(1-Methyl-1H-1,3-benzodiazol-2-yl)-1-propyl-1H-1,3-benzodiazole

2-N-PROPYL-4-METHYL-6-(1-METHYLABENZIMIDAZOLE-2-YL) BENZIMIDAZOLE

TelMisartan EP IMpurity A (USP RC A*)

2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL-2-YL)-BENZIMIDAZOLE

2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)-1H-BENZIMIDAZOLE

2-N-PROPYL-4-METHYL-6-(1'-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE

2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE

2-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE

1H-BENZIMIDAZOL-2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL)-2-YL

Telmisartan Related Compound A (20 mg) (1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole)

2-n-propyl-4-Methyl-6-(1-MethylbenziMidazole-2-yl)benziMidazole(MPB)

1,7'-DIMETHYL-2'-PROPYL-1H,3'H-[2,5']BIBENZIMIDAZOLE

2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIIMIDAZOLE-2-YL)BENZIIMIDAZOLE

1,7'-Dimethyl-2'-Propyl-2,5'-Bi-1h-Benzimidazole

4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazole

Telmisartan Impurity 2

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole ,CAS No: 152628-02-9 , TelMisartan IMpurity A CAS NO.152628-02-9

1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole

Telmisartan Impurity 2(Telmisartan EP Impurity A)

2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-ly) benzimidazole

7-methyl-5-(1-methyl-2-benzimidazolyl)-2-propyl-3aH-benzimidazole

Telmisartan RC-A

Telmisartan EP Impurity A/ USP Telmisartan Related Compound A

Telmisartan EP Impurity A/ Telmisartan Related Compound A

2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-Yl)Benzimidaz...

Telmisartan impurities1035

Telmisartan EP Impurity AQ: What is Telmisartan EP Impurity A Q: What is the CAS Number of Telmisartan EP Impurity A Q: What is the storage condition of Telmisartan EP Impurity A Q: What are the applications of Telmisartan EP Impurity A

4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole

Telmisartan Impurity A（EP）

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole/Telmisartan Intermediate

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS NO.152628-02-9

3'2-n-propyl-4-methyl-6-(1- methylbenzimidazole-2-yl)-1H-benzimidazole

4-Methyl-6-(1-Methylbenzimidazole-2-yl)-2-propyl benzimidazole

2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-Yl)Benzimidazole