ChemicalBook > CAS DataBase List > 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Product Name
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
CAS No.
152628-02-9
Chemical Name
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
Synonyms
4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole;2-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE;Telmisartan EP Impurity A;2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole;Telmisartan RC-A;Bis-Benzoimidazole;TelMisartan IMpurity A;Telmisartan Impurity 2;Telmisartan impurities1035;Telmisartan Impurity A（EP）
CBNumber
CB7153796
Molecular Formula
C19H20N4
Formula Weight
304.39
MOL File
152628-02-9.mol
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2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Property

Melting point:
130-135 °C(Solv: tetrahydrofuran (109-99-9))
Boiling point:
584.8±52.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
Powder
pka
11.86±0.30(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C19H20N4/c1-4-7-17-20-15-11-13(10-12(2)18(15)22-17)19-21-14-8-5-6-9-16(14)23(19)3/h5-6,8-11H,4,7H2,1-3H3,(H,20,22)
InChIKey
ILXRSCZVHSZGCS-UHFFFAOYSA-N
SMILES
C1(C2=CC(C)=C3NC(CCC)=NC3=C2)N(C)C2=CC=CC=C2N=1
LogP
3.49 at 20℃ and pH6
CAS DataBase Reference
152628-02-9(CAS DataBase Reference)
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5079
Product name
1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole
Packaging
5G
Price
$95
Updated
2025/07/31
TCI Chemical
Product number
D5079
Product name
1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole
Packaging
25G
Price
$328
Updated
2025/07/31
TRC
Product number
P838280
Product name
2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole
Packaging
50mg
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
072121
Product name
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
Purity
95+%
Packaging
1g
Price
$20
Updated
2021/12/16
AK Scientific
Product number
J10673
Product name
Telmisartan Related Compound A
Packaging
25mg
Price
$20
Updated
2021/12/16
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2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Grey Powder

Uses

An impurity found in Telmisartan (T017000).

Synthesis

25148-68-9

152628-03-0

152628-02-9

General procedure for the synthesis of 1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-dibenzo[d]imidazole from N-methyl-o-phenylenediamine hydrochloride and 2-n-propyl-4-methyl-6-carboxybenzimidazole: Suspension of 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid (50 g) in poly(phosphoric acid) (300 g) was heated to 70-75 °C and maintained for 30 minutes. Subsequently, N-methylphthalimide dihydrochloride (45 g) was added in batches for 2 hours and the reaction was continued at 70-75°C for 1 hour. Next, the temperature of the reaction mixture was raised to 130-135°C and maintained for 10 hours. Upon completion of the reaction, the mixture was cooled to 70°C and water (600 mL) was slowly added to maintain the temperature at 60-90°C. Cooling was continued to 30 °C and the pH was adjusted to 8.0-8.5 with an aqueous ammonia solution.Subsequently, the reaction mixture was heated to 50-55 °C and held for 1 h. The solids were collected by filtration and the wet filter cake was washed with hot water (200 ml). The wet filter cake was suspended in water (900 mL), heated to 50-55 °C, stirred for 1 h and filtered, then washed with hot water (100 mL), and the wet filter cake was dried at 70-75 °C to constant weight. The dried product was suspended in methanol (260 mL), heated to 45-50 °C, activated carbon (6.5 g) was added and stirred for 30 min. Insoluble material was removed by filtration through a Hyflo bed, the bed was washed with hot methanol (60 mL), the filtrates were combined and cooled to 25 °C. Water (160 mL) was slowly added to the filtrate at 25-35°C, heated to reflux temperature and held for 1 hour. The reaction mixture was cooled to 0-5 °C and maintained for 2 h. The resulting solid was filtered, washed with methanol (60 mL) and the wet filter cake was dried at 70-75 °C to constant weight to give 54 g of 4-methyl-6-(1-methylbenzimidazol-2-yl)-2- n-propyl-1H-benzimidazole (77.4% yield), with a water content of 5.85% as determined by KF.

References

[1] Patent: WO2007/10558, 2007, A1. Location in patent: Page/Page column 5; 10-11
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 161 - 178

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-20
Henan Aochuang Chemical Co.,Ltd.
Product
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10
Baoji Guokang Healthchem Co., Ltd.
Product
2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9
Price
US $115.00/Kg/Bag
Min. Order
25KG
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-03

152628-02-9, 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazoleRelated Search:

Telmisartan tert-Butyl Ester Kresoxim-methyl Cyclopropyl methyl ketone Methyl salicylate Propyl gallate Isopropyl alcohol Benzimidazole Tribenuron methyl ALLYL METHYL ETHER Propyl butyrate N,N-Dimethylallylamine 3-Methyl-2-butanone Telmisartan Telmisartan sodium 4-Bromomethyl-2-cyanobiphenyl Telmisartan impurity Thiophanate-methyl TELMISARTAN-D3

  • 1,7'-diMethyl-2'-propyl-1H,3'H-
  • TelMisartan IMpurity A(2-n-propyl-4-Methyl-6-(1-MethylbenziMidazole-2-yl)benziMidazole)
  • TelMisartan IMpurity A
  • TelMisartan Related CoMpound A
  • 4-Methyl-2-propyl-6-benziMidazolecarboxylic Acid, 97+%
  • 2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
  • Imp. A:2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazole
  • 1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole
  • NA###2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
  • 1H-BENZIMIDAZOLE 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)
  • 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE(INTERMEDIATE OF TELMISARTAN)
  • 1H-Benzimidazole-2-N-Propyl-4-Methyl-6-(1-Methylbenzimidiazole-2-Yl)
  • 2-N-Propyl-4-Methyl-6-(1-MethylBenzimidazole-2-Yl)-Benzimidazole[TelmisartanIntermediates]
  • 2-N-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-BenzimidazoleTelmisartanMethylEster
  • Bis-Benzoimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)–benzimidazole
  • Telmisartan EP Impurity A
  • 4,4''-DIMETHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE
  • 7''-METHYL-2''-PROPYL-1H,3''H-2,5''-BIBENZO[D]IMIDAZOLE
  • 1,4''-DIMETHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE
  • 4''-METHYL-2''-PROPYL-1H,1''H-2,5''-BIBENZO[D]IMIDAZOLE
  • 2-N-Propyl-4-Methyl-6-(1-Methy
  • Bis-Benzoimidazole
  • 2,5'-bi-1H-Benzimidazole,1,7'-dimethyl-2'-propyl-
  • 2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-YI)Benzimidazole
  • 7-Methyl-5-(1-Methyl-1H-1,3-benzodiazol-2-yl)-1-propyl-1H-1,3-benzodiazole
  • 2-N-PROPYL-4-METHYL-6-(1-METHYLABENZIMIDAZOLE-2-YL) BENZIMIDAZOLE
  • TelMisartan EP IMpurity A (USP RC A*)
  • 2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL-2-YL)-BENZIMIDAZOLE
  • 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)-1H-BENZIMIDAZOLE
  • 2-N-PROPYL-4-METHYL-6-(1'-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE
  • 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE
  • 2-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE
  • 1H-BENZIMIDAZOL-2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL)-2-YL
  • Telmisartan Related Compound A (20 mg) (1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole)
  • 2-n-propyl-4-Methyl-6-(1-MethylbenziMidazole-2-yl)benziMidazole(MPB)
  • 1,7'-DIMETHYL-2'-PROPYL-1H,3'H-[2,5']BIBENZIMIDAZOLE
  • 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIIMIDAZOLE-2-YL)BENZIIMIDAZOLE
  • 1,7'-Dimethyl-2'-Propyl-2,5'-Bi-1h-Benzimidazole
  • 4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazole
  • Telmisartan Impurity 2
  • 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole ,CAS No: 152628-02-9 , TelMisartan IMpurity A CAS NO.152628-02-9
  • 1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole
  • Telmisartan Impurity 2(Telmisartan EP Impurity A)
  • 2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-ly) benzimidazole
  • 7-methyl-5-(1-methyl-2-benzimidazolyl)-2-propyl-3aH-benzimidazole
  • Telmisartan RC-A
  • Telmisartan EP Impurity A/ USP Telmisartan Related Compound A
  • Telmisartan EP Impurity A/ Telmisartan Related Compound A
  • 2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-Yl)Benzimidaz...
  • Telmisartan impurities1035
  • Telmisartan EP Impurity AQ: What is Telmisartan EP Impurity A Q: What is the CAS Number of Telmisartan EP Impurity A Q: What is the storage condition of Telmisartan EP Impurity A Q: What are the applications of Telmisartan EP Impurity A
  • 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole
  • Telmisartan Impurity A（EP）
  • 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole/Telmisartan Intermediate
  • 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS NO.152628-02-9
  • 3'2-n-propyl-4-methyl-6-(1- methylbenzimidazole-2-yl)-1H-benzimidazole
  • 4-Methyl-6-(1-Methylbenzimidazole-2-yl)-2-propyl benzimidazole
  • 2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazol-2-Yl)Benzimidazole