ChemicalBook > CAS DataBase List > 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Product Name: 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS No.: 128455-63-0
Chemical Name: 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms: BUTTPARK 99\18-36;RARECHEM AL BO 1764;5-Chloro-1-methyl-3-(trifluoromethyl);4-Carboxy-5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole;5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carboxylic acid;5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxyl...;5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-3-(trifluoromethyl)-;5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid97%
CBNumber: CB7155068
Molecular Formula: C6H4ClF3N2O2
Formula Weight: 228.56
MOL File: 128455-63-0.mol

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5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Property

Melting point:: 201 °C
Boiling point:: 284.4±40.0 °C(Predicted)
Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.77±0.50(Predicted)
CAS DataBase Reference: 128455-63-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC6318
Product name: 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Packaging: 250mg
Price: $29
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-7-09
Product name: 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $32
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC98081
Product name: 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Packaging: 100mg
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC98081
Product name: 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11119
Product name: 5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $70
Updated: 2021/12/16

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5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

128455-62-9

128455-63-0

Example 5: 10 g of 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde was added to 50 mL of an aqueous solution containing 5 g of sodium hydroxide (2 equivalents). Under vigorous stirring, 34.4 g of 35% hydrogen peroxide solution was slowly added in 8 drops over a temperature range of 40°C to 50°C, taking 1.5 hours. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes and subsequently cooled to 15°C. The pH of the reaction solution was adjusted to 1 with concentrated hydrochloric acid and the solid product was precipitated. The crystals were collected by filtration and washed well with water, after which the crystals were dissolved in ether. The ether solution was dried over anhydrous magnesium sulfate and decolorized by activated carbon, and then the ether was removed by distillation under reduced pressure to give 8.6 g of 5-chloro-1-methyl-3-(trifluoromethyl)pyrrole-4-carboxylic acid in 80.0% yield and 197.5-199.5 °C melting point.

References

[1] Patent: US2004/19221, 2004, A1. Location in patent: Page 7
[2] Patent: CN103951663, 2016, B. Location in patent: Paragraph 0091; 0096; 0097
[3] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 243 - 245
[4] Patent: WO2007/84868, 2007, A2. Location in patent: Page/Page column 39
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 2, p. 389 - 396

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 128455-63-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-31

128455-63-0, 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDRelated Search:

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-1-METHYL-5-TRIFLUOROMETHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE 4-CHLORO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDRAZIDE O1-([5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]CARBONYL)-4-CHLOROBENZENE-1-CARBOHYDROXIMAMIDE O1-([5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]CARBONYL)-4-(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDROXIMAMIDE 5-CHLORO-4-METHOXYCARBONYL-1-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE RARECHEM AL BI 0329 4-CARBOXY-5-CHLORO-1-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE RARECHEM AL BF 0329 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid97%

5-Chloro-1-methyl-3-(trifluoromethyl)

BUTTPARK 99\18-36

5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

RARECHEM AL BO 1764

4-Carboxy-5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole

5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carboxylic acid

1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-3-(trifluoromethyl)-

5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxyl...

128455-63-0

C6H4ClF3N2O2

C6H3ClF3N2O2

Carboxylic Acids

Pyrazoles & Triazoles

Heterocyclic Building Blocks

New Products for Chemical Synthesis

Pyrazoles

Building Blocks

Pyrazole

Chemical Synthesis

Carboxylic Acids

Pyrazoles & Triazoles