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2-bromo-5-cyanobenzoic acid

Product Name
2-bromo-5-cyanobenzoic acid
CAS No.
845616-12-8
Chemical Name
2-bromo-5-cyanobenzoic acid
Synonyms
2-bromo-5-cyanobenzoic acid;2-bromo-5-cyanobenozic acid;BENZOIC ACID, 2-BROMO-5-CYANO-
CBNumber
CB71557735
Molecular Formula
C8H4BrNO2
Formula Weight
226.03
MOL File
845616-12-8.mol
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2-bromo-5-cyanobenzoic acid Property

Melting point:
183-185°
storage temp. 
Sealed in dry,Room Temperature
form 
powder
color 
yellow
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B292840
Product name
2-Bromo-5-cyanobenzoicAcid
Packaging
50mg
Price
$65
Updated
2021/12/16
TRC
Product number
B292840
Product name
2-Bromo-5-cyanobenzoicAcid
Packaging
100mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-W019084
Product name
2-Bromo-5-cyanobenzoicacid
Packaging
1g
Price
$245
Updated
2021/12/16
ChemScene
Product number
CS-W019084
Product name
2-Bromo-5-cyanobenzoicacid
Packaging
100mg
Price
$66
Updated
2021/12/16
ChemScene
Product number
CS-W019084
Product name
2-Bromo-5-cyanobenzoicacid
Packaging
250mg
Price
$98
Updated
2021/12/16
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2-bromo-5-cyanobenzoic acid Chemical Properties,Usage,Production

Synthesis

99767-45-0

845616-12-8

The general procedure for the synthesis of 2-bromo-5-cyanobenzoic acid from 2-amino-5-cyanobenzoic acid was as follows: tert-butyl nitrite (1.15 ml, 8.63 mmol) was added dropwise over 2 min at 0 °C to a suspension of copper (II) bromide (1.6 g, 7.1 mmol) in acetonitrile (30 ml). Subsequently, 2-amino-5-cyanobenzoic acid (1.0 g, 6.17 mmol) was added in batches over 10 min at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, then brought to room temperature and stirred overnight. After completion of the reaction, half of the solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of 1N HCl (15 ml) and ethyl acetate (30 ml). The organic layer was extracted with 1N NaOH (3 x 10 ml). The aqueous layer was acidified with 2N HCl and a solid was precipitated. The solid was collected by filtration, washed with water and dried under high vacuum at 50°C to give 2-bromo-5-cyanobenzoic acid (0.92 g, 66% yield) as a yellow solid.

References

[1] Patent: WO2005/23260, 2005, A1. Location in patent: Page/Page column 48
[2] Patent: US2005/209241, 2005, A1. Location in patent: Page/Page column 20

2-bromo-5-cyanobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-5-cyanobenzoic acid Suppliers

China 50 India 2 United Kingdom 1 United States 4 Global 57
Synthonix Inc
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United States
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6872
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Beta Pharma, Inc.
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sales@betapharma.com
Country
United States
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6226
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SynQuest Laboratories, Inc.
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info@synquestlabs.com
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United States
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6871
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Matrix Scientific
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Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

845616-12-8, 2-bromo-5-cyanobenzoic acidRelated Search:


  • 2-bromo-5-cyanobenzoic acid
  • BENZOIC ACID, 2-BROMO-5-CYANO-
  • 2-bromo-5-cyanobenozic acid
  • 845616-12-8