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Methyl 2-(hydroxymethyl)isonicotinate

Product Name
Methyl 2-(hydroxymethyl)isonicotinate
CAS No.
58481-17-7
Chemical Name
Methyl 2-(hydroxymethyl)isonicotinate
Synonyms
Methyl 2-(hydroxyMethyl) isonicotinate;2-Hydroxymethyl-isonicotinic acid methyl ester;Methyl 2-(hydroxymethyl)pyridine-4-carboxylate;2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester;2-(Hydroxymethyl)Isonicotinic Acid 2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
CBNumber
CB71558141
Molecular Formula
C8H9NO3
Formula Weight
167.16
MOL File
58481-17-7.mol
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Methyl 2-(hydroxymethyl)isonicotinate Property

Boiling point:
304.2±32.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.20±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
Y9548
Product name
2-(Hydroxymethyl)pyridine-4-carboxylicacid
Packaging
100mg
Price
$155
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0098187
Product name
2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$496.53
Updated
2021/12/16
Matrix Scientific
Product number
126639
Product name
Methyl2-(hydroxymethyl)isonicotinate
Purity
>95%
Packaging
1g
Price
$1404
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0098187
Product name
2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$997.5
Updated
2021/12/16
Chemenu
Product number
CM121034
Product name
Methyl2-(Hydroxymethyl)pyridine-4-carboxylate
Purity
97%
Packaging
10g
Price
$1328
Updated
2021/12/16
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Methyl 2-(hydroxymethyl)isonicotinate Chemical Properties,Usage,Production

Synthesis

The reaction was performed in 2 separate 1000 mL round-bottomed flasks. To a solution of methyl isonicotinate (70 g, 510.44 mmol) and sulfuric acid (2.340 mL, 43.90 mmol) in MeOH (700 mL) under reflux added a solution of ammonium peroxydisulfate (210 g, 918.80 mmol) in water (350 mL) over 20 min. The reaction was refluxed for 20 min and was then allowed to cool to room temperature. The solid was filtered off and washed with MeOH. After that, MeOH was removed from the filtrate under reduced pressure and then neutralized by cautious stepwise addition of solid Na2CO3 under ice-cooling. The aqueous solution was extracted with ethyl acetate and the combined organic layers were dried with Na2SO4 and evaporated. The dark-brown residue was treated with cyclohexane (3×300 mL) and the cyclohexane phase was decanted. The remaining dark-brown residue was purified by automated flash chromatography on 2 Biotage KP-SIL 340 g columns. A gradient from 25% to 100% of EtOAc in heptane over 10 CV was used as the mobile phase. Methyl 2-(hydroxymethyl)isonicotinate (27.5 g, 32%) was isolated.

Methyl 2-(hydroxymethyl)isonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-(hydroxymethyl)isonicotinate manufacturers

Career Henan Chemical Co
Product
2-Hydroxymethyl-isonicotinic acid methyl ester 58481-17-7
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

58481-17-7, Methyl 2-(hydroxymethyl)isonicotinateRelated Search:


  • 2-Hydroxymethyl-isonicotinic acid methyl ester
  • 4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester
  • 2-(Hydroxymethyl)Isonicotinic Acid 2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
  • Methyl 2-(hydroxyMethyl) isonicotinate
  • Methyl 2-(hydroxymethyl)pyridine-4-carboxylate
  • 2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester
  • 58481-17-7