Methyl 2-(hydroxymethyl)isonicotinate

Product Name: Methyl 2-(hydroxymethyl)isonicotinate
CAS No.: 58481-17-7
Chemical Name: Methyl 2-(hydroxymethyl)isonicotinate
Synonyms: Methyl 2-(hydroxyMethyl) isonicotinate;2-Hydroxymethyl-isonicotinic acid methyl ester;Methyl 2-(hydroxymethyl)pyridine-4-carboxylate;2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester;2-(Hydroxymethyl)Isonicotinic Acid 2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
CBNumber: CB71558141
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 58481-17-7.mol

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Methyl 2-(hydroxymethyl)isonicotinate Property

Boiling point:: 304.2±32.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.20±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y9548
Product name: 2-(Hydroxymethyl)pyridine-4-carboxylicacid
Packaging: 100mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0098187
Product name: 2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $496.53
Updated: 2021/12/16

Matrix Scientific

Product number: 126639
Product name: Methyl2-(hydroxymethyl)isonicotinate
Purity: >95%
Packaging: 1g
Price: $1404
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0098187
Product name: 2-HYDROXYMETHYL-ISONICOTINIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $997.5
Updated: 2021/12/16

Chemenu

Product number: CM121034
Product name: Methyl2-(Hydroxymethyl)pyridine-4-carboxylate
Purity: 97%
Packaging: 10g
Price: $1328
Updated: 2021/12/16

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Methyl 2-(hydroxymethyl)isonicotinate Chemical Properties,Usage,Production

Synthesis

The reaction was performed in 2 separate 1000 mL round-bottomed flasks. To a solution of methyl isonicotinate (70 g, 510.44 mmol) and sulfuric acid (2.340 mL, 43.90 mmol) in MeOH (700 mL) under reflux added a solution of ammonium peroxydisulfate (210 g, 918.80 mmol) in water (350 mL) over 20 min. The reaction was refluxed for 20 min and was then allowed to cool to room temperature. The solid was filtered off and washed with MeOH. After that, MeOH was removed from the filtrate under reduced pressure and then neutralized by cautious stepwise addition of solid Na2CO3 under ice-cooling. The aqueous solution was extracted with ethyl acetate and the combined organic layers were dried with Na2SO4 and evaporated. The dark-brown residue was treated with cyclohexane (3×300 mL) and the cyclohexane phase was decanted. The remaining dark-brown residue was purified by automated flash chromatography on 2 Biotage KP-SIL 340 g columns. A gradient from 25% to 100% of EtOAc in heptane over 10 CV was used as the mobile phase. Methyl 2-(hydroxymethyl)isonicotinate (27.5 g, 32%) was isolated.

Methyl 2-(hydroxymethyl)isonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-(hydroxymethyl)isonicotinate Suppliers

China 75 India 2 United States 5 Global 82

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View Lastest Price from Methyl 2-(hydroxymethyl)isonicotinate manufacturers

Career Henan Chemical Co

Product: 2-Hydroxymethyl-isonicotinic acid methyl ester 58481-17-7
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

58481-17-7, Methyl 2-(hydroxymethyl)isonicotinateRelated Search:

2-Hydroxymethyl-isonicotinic acid methyl ester

4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester

2-(Hydroxymethyl)Isonicotinic Acid 2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID

Methyl 2-(hydroxyMethyl) isonicotinate

Methyl 2-(hydroxymethyl)pyridine-4-carboxylate

2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester

58481-17-7