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Retigabine Dihydrochloride

Product Name
Retigabine Dihydrochloride
CAS No.
150812-13-8
Chemical Name
Retigabine Dihydrochloride
Synonyms
D 20443;CS-2270;Retigabin.2HCl;Retigabine HCl;Retigabine 2HCL;Retigabine DiHCl;D20443 dihydrochloride;D-20443 dihydrochloride;D 20443 dihydrochloride;Retigabine Dihydrochloride
CBNumber
CB71565451
Molecular Formula
C16H20Cl2FN3O2
Formula Weight
376.2
MOL File
150812-13-8.mol
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Retigabine Dihydrochloride Property

Melting point:
168-170°C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BR164335
Product name
Retigabine dihydrochloride
Packaging
10mg
Price
$126
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
50mg
Price
$191
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR164335
Product name
Retigabine dihydrochloride
Packaging
50mg
Price
$293
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
100mg
Price
$333
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
5mg
Price
$47
Updated
2021/12/16
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Retigabine Dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Drug interactions

 A clinical interaction study showed that there was no pharmacokinetic interaction between phenobarbitone and retigabine in healthy subjects. Thus, no dosage adjustment is likely to be necessary when phenobarbitone and retigabine are coadministered to patients 

Uses

A new experimental anticonvulsant drug. Anxiolytic.
Retigabine Dihydrochloride (0.1 ~ 10 μM) induced a potassium current and hyperpolarized CHO-KCNQ2/Q3 cells but not in wild-type cells. In the 6-Hz psychomotor seizure model, Retigabine Dihydrochloride dose-dependently blocked seizures induced by either 32 or 44 mA current stimulation.

Biological Activity

Retigabine is a first-in-class k+ channel (kcnq) opener. kcnq channels are reported to be expressed predominantly in neurons and are critical determinants of cellular excitability, as shown by the occurrence of human genetic mutations in kcnq channels which underlie inheritable disorders including the syndrome of benign familial neonatal convulsions.

in vitro

retigabine was found to combine a novel mode of actions, which were namely potassium channel opening (kcnq2, kcnq3 as well as kcnq4 channels). retigabine also showed activities with some potentiation of gamma amino butyric acid (gaba)-evoked currents at its higher concentrations [1].

in vivo

animal models of epileptic seizures showed that retigabine treatment was effective at an oral dose as low as 0.01 mg/kg. studies performed in mice also indicated that combining retigabine with another anticonvulsant agent leads to an additive effect [1].

References

[1] ferron gm,patat a,parks v,rolan p,troy sm. lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. br j clin pharmacol.2003 jul;56(1):39-45.

Retigabine Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Retigabine Dihydrochloride Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
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View Lastest Price from Retigabine Dihydrochloride manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
Retigabine Dihydrochloride 150812-13-8
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-27
Hebei Chuanghai Biotechnology Co,.LTD
Product
Tiotropium Bromide 150812-13-8
Price
US $11.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Retigabine Dihydrochloride 150812-13-8
Price
US $60.00-150.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
50
Release date
2024-07-09

150812-13-8, Retigabine DihydrochlorideRelated Search:


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  • Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate Dihydrochloride
  • N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester Dihydrochloride
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  • Retigabine HCl
  • D 20443 dihydrochloride
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  • D-20443 dihydrochloride
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  • Retigabine DiHCl
  • D 20443 DIHYDROCHLORIDE; D-20443 DIHYDROCHLORIDE; D20443 DIHYDROCHLORIDE
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  • Retigabine dihydrochloride- Bio-X
  • 150812-13-8
  • C16H20Cl2FN3O2
  • C16H18FN3O22HCl
  • C16H19ClFN3O2
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