ChemicalBook > CAS DataBase List > BREVETOXIN B

BREVETOXIN B

Product Name
BREVETOXIN B
CAS No.
79580-28-2
Chemical Name
BREVETOXIN B
Synonyms
gb2;t4-7;btx-b;PBTX-2;GBTX-2;gb2toxin;toxint-34;t4-7toxin;BREVETOXIN B;BREVETOXIN 2
CBNumber
CB7161922
Molecular Formula
C50H70O14
Formula Weight
895.08
MOL File
79580-28-2.mol
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BREVETOXIN B Property

Melting point:
270(Disassembly)
Density 
1.188±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Ethyl Acetate: soluble
form 
A film
pka
13.72±0.70(Predicted)
color 
tan to white
optical activity
+154.022 (CHCl3)
Water Solubility 
ethyl acetate: soluble
methanol: soluble
water: soluble
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
XW5886000
HazardClass 
6.1(a)
PackingGroup 
I
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
203732
Product name
Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem
Purity
Lipid-solublepolyetherneurotoxinthatbindstoNa+channelsonnervesandmusc
Packaging
100μg
Price
$732
Updated
2025/07/31
Cayman Chemical
Product number
10011498
Product name
Brevetoxin B
Purity
≥95%
Packaging
100μg
Price
$275
Updated
2024/03/01
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BREVETOXIN B Chemical Properties,Usage,Production

Description

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Uses

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

Definition

ChEBI: Brevetoxin B is a ciguatoxin.

BREVETOXIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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BREVETOXIN B Suppliers

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  • Gb 2 (gymnodinium)
  • Brevetoxin 2 solution
  • Brevetoxin PbTx-2,<i> Ptychodiscus brevis</i>
  • 79580-28-2
  • C30H22O12
  • C50H70O14
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Other Sodium Channel Modulators
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Ion Channels
  • Monovalent Ion Channels