2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE
- Product Name
- 2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE
- CAS No.
- 828-81-9
- Chemical Name
- 2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE
- Synonyms
- 5-(2-Chlorophenyl);VITAS-BB TBB000090;IFLAB-BB F1386-0067;5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOL-2-AMINE;2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE;1,3,4-Thiadiazol-2-aMine, 5-(2-chlorophenyl)-;5-(2-CHLORO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- CBNumber
- CB7162141
- Molecular Formula
- C8H6ClN3S
- Formula Weight
- 211.67
- MOL File
- 828-81-9.mol
2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE Property
- Melting point:
- 192-195 °C
- Boiling point:
- 393.8±44.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 2.28±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- C350815
- Product name
- 5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-amine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 009946
- Product name
- 5-(2-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine
- Packaging
- 1g
- Price
- $113
- Updated
- 2021/12/16
- Product number
- CHM0033140
- Product name
- 2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- V7899
- Product name
- 5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-amine
- Packaging
- 10g
- Price
- $824
- Updated
- 2021/12/16
- Product number
- CHM0033140
- Product name
- 2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE Chemical Properties,Usage,Production
Synthesis
79-19-6
118-91-2
828-81-9
5.1.1 Synthesis of 5-(2-chlorophenyl)-1,3,4-thiadiazol-2-amine (68): 2-chlorobenzoic acid (5.18 g, 25 mmol) and aminothiourea (2.28 g, 25 mmol) were dissolved in POCl3 (7 ml) and stirred vigorously for 0.5 hr at 75 °C. After completion of the reaction, H2O (30 ml) was added and the mixture was heated to reflux for 4 hours. Subsequently, the reaction mixture was adjusted with 50% NaOH solution to pH 8. The precipitate was collected by filtration and the filter cake was purified by recrystallization from ethanol to give the yellow crystalline product 68 in a yield of 3.90 g, 88% yield, melting point 190-192 °C (EtOH). The product was analyzed by ESI-MS, m/z: 212.1 [M + H]+; 1H NMR (CDCl3) δ 7.45-7.50 (m, 4H), 7.60-7.62 (m, 1H), 7.99-8.01 (m, 1H). Compounds 60-81 were synthesized in the same way.
References
[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 8, p. 998 - 1001
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
[3] Medicinal Chemistry Research, 2018, vol. 27, # 7, p. 1800 - 1821
[4] Medicinal Chemistry Research, 2012, vol. 21, # 6, p. 816 - 824
[5] Journal of Chemical Research, 2014, vol. 38, # 6, p. 347 - 350
2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE manufacturers
- Product
- 5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-amine 828-81-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20