Picotamide

Product Name: Picotamide
CAS No.: 32828-81-2
Chemical Name: Picotamide
Synonyms: g137;PICOTAMIDE;N,N’-Bis(3-Pyridinylmethyl)-4-Me;n,n’-bis(3-picolyl)-4-methoxyisophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid;4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide;Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-;n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide;4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE
CBNumber: CB7167904
Molecular Formula: C21H20N4O3
Formula Weight: 376.41
MOL File: 32828-81-2.mol

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Picotamide Property

Melting point:: 128-131℃
Boiling point:: 668.1±55.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
pka: 13.31±0.46(Predicted)
form: White solid.
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 2
RTECS: CZ2235500
Toxicity: LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8477
Product name: Picotamide
Packaging: 5mg
Price: $277
Updated: 2024/03/01

Alfa Aesar

Product number: J67232
Product name: Picotamide, 98%
Packaging: 10mg
Price: $144.9
Updated: 2023/01/06

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 25mg
Price: $239
Updated: 2024/03/01

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Picotamide Chemical Properties,Usage,Production

Description

Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.

Originator

Manetti-Roberts (Beecham (Italy)

Uses

Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.

Uses

Keratolytic.

Definition

ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.

brand name

Plactidil

References

Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77

Picotamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Picotamide Suppliers

China 22 Europe 2 France 1 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 17 Global 49

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8073
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai Vigor Biotechnology Co., Ltd.

Tel: info@vigorchem.cn 1801605789
Fax: QQ：1801605789
Country: China
ProdList: 169
Advantage: 58

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 15502154572
Fax: -
Email: yuben012@sina.com
Country: China
ProdList: 503
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9923
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

32828-81-2, PicotamideRelated Search:

N-Eicosanoyl Serotonin DO264 Ibrutinib 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 3-METHYL-4-METHOXYBENZYLAMINE (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE ISOPHTHALAMIDE (2-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE 5-Methylsalicylamide 3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide Picotamide

4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE

PICOTAMIDE

4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid

4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide

g137

n,n’-bis(3-picolyl)-4-methoxyisophthalamide

n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide

n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide

4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide

-1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy

Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-

N,N’-Bis(3-Pyridinylmethyl)-4-Me

4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide

1,3-Benzenedicarboxamide, 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-

inhibit,Picotamide,Inhibitor,Prostaglandin Receptor,Antiplatelet,Microalbuminuria,Carotid plaques

32828-81-2

C21H20N4O3H2O

C21H20N4O3

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Thromboxane synthase

R to Z

BioChemical

Biochemicals and Reagents