ChemicalBook > CAS DataBase List > Picotamide

Picotamide

Product Name: Picotamide
CAS No.: 32828-81-2
Chemical Name: Picotamide
Synonyms: g137;PICOTAMIDE;Picotamide, 10 mM in DMSO;N,N’-Bis(3-Pyridinylmethyl)-4-Me;n,n’-bis(3-picolyl)-4-methoxyisophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid;4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide;Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-;4-Methoxy-N1,N3-bis(pyridin-3-ylmethyl)isophthalamide
CBNumber: CB7167904
Molecular Formula: C21H20N4O3
Formula Weight: 376.41
MOL File: 32828-81-2.mol

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Picotamide Property

Melting point:: 128-131℃
Boiling point:: 668.1±55.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
pka: 13.31±0.46(Predicted)
form: White solid.
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 2
RTECS: CZ2235500
Toxicity: LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8477
Product name: Picotamide
Packaging: 5mg
Price: $200.2
Updated: 2025/07/31

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 25mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 21690
Product name: Picotamide
Purity: ≥98%
Packaging: 50mg
Price: $419
Updated: 2024/03/01

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Picotamide Chemical Properties,Usage,Production

Description

Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.

Originator

Manetti-Roberts (Beecham (Italy)

Uses

Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.

Uses

Keratolytic.

Definition

ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.

brand name

Plactidil

References

[1] PIETRO A. MODESTI. Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide[J]. European journal of pharmacology, 1989, 169 1: Pages 85-93. DOI:10.1016/0014-2999(89)90820-0
[2] PA MODESTI. Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 receptor inhibitor.[J]. British journal of clinical pharmacology, 1991, 31 4: 439-443. DOI:10.1111/j.1365-2125.1991.tb05560.x
[3] SARA RATTI . Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes1[J]. European journal of pharmacology, 1998, 355 1: Pages 77-83. DOI:10.1016/s0014-2999(98)00467-1

Picotamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Picotamide Suppliers

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View Lastest Price from Picotamide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Picotamide 32828-81-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-01

32828-81-2, PicotamideRelated Search:

N-Eicosanoyl Serotonin DO264 Ibrutinib 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 3-METHYL-4-METHOXYBENZYLAMINE (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE ISOPHTHALAMIDE (2-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE 5-Methylsalicylamide 3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide Picotamide

PICOTAMIDE

4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid

4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide

g137

n,n’-bis(3-picolyl)-4-methoxyisophthalamide

n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide

n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide

4-methoxy-N,N'-bis(3-pyridylmethyl)isophthaldiamide

-1,3-Benzenedicarboxamide, N,N'-bis(3-pyridinylmethyl)-4-methoxy

Isophthalamide, 4-methoxy-N,N'-bis(3-pyridylmethyl)-

N,N’-Bis(3-Pyridinylmethyl)-4-Me

4-methoxy-1-N,3-N-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide

1,3-Benzenedicarboxamide, 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-

inhibit,Picotamide,Inhibitor,Prostaglandin Receptor,Antiplatelet,Microalbuminuria,Carotid plaques

4-Methoxy-N1,N3-bis(pyridin-3-ylmethyl)isophthalamide

4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

Picotamide, Thromboxane A2 antagonist and TXA2 synthase inhibitor

Picotamide, 10 mM in DMSO

32828-81-2

C21H20N4O3H2O

C21H20N4O3

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Thromboxane synthase

R to Z

BioChemical

Biochemicals and Reagents