2-amino-N,N-dimethylbenzenesulfonamide
- Product Name
- 2-amino-N,N-dimethylbenzenesulfonamide
- CAS No.
- 54468-86-9
- Chemical Name
- 2-amino-N,N-dimethylbenzenesulfonamide
- Synonyms
- UKRORGSYN-BB BBV-033364;2-amino-N,N-dimethylbenzenesulfonamide;Benzenesulfonamide, 2-amino-N,N-dimethyl-;2-aMino-N,N-diMethylbenzene-1-sulfonaMide;2-amino-N,N-dimethylbenzenesulfonamide(SALTDATA: FREE)
- CBNumber
- CB71685986
- Molecular Formula
- C8H12N2O2S
- Formula Weight
- 200.26
- MOL File
- 54468-86-9.mol
2-amino-N,N-dimethylbenzenesulfonamide Property
- Melting point:
- 86-88 °C
- Boiling point:
- 347.3±44.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- -0.12±0.10(Predicted)
- color
- Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A604585
- Product name
- 2-Amino-N,N-dimethylbenzenesulfonamide
- Packaging
- 5g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- FA153590
- Product name
- 2-Amino-N,N-dimethylbenzenesulfonamide
- Packaging
- 5G
- Price
- $426
- Updated
- 2021/12/16
- Product number
- CS-W021581
- Product name
- 2-Amino-N,N-dimethylbenzenesulfonamide
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- FA153590
- Product name
- 2-Amino-N,N-dimethylbenzenesulfonamide
- Packaging
- 10g
- Price
- $724
- Updated
- 2021/12/16
- Product number
- 072355
- Product name
- 2-Amino-N,N-dimethylbenzenesulfonamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $899
- Updated
- 2021/12/16
2-amino-N,N-dimethylbenzenesulfonamide Chemical Properties,Usage,Production
Uses
2-Amino-N,N-dimethylbenzenesulfonamide is an intermediate used to prepare LDK378 as potent and selective anaplastic lymphoma kinase inhibitor.
Synthesis
23530-43-0
54468-86-9
General procedure for the synthesis of 2-amino-N,N-dimethylbenzenesulfonamide from N,N-dimethyl-2-nitrobenzenesulfonamide: N,N-dimethyl-2-nitrobenzenesulfonamide (2.5 g, 10.9 mmol) was dissolved in methanol (100 mL), and palladium/carbon catalyst (250 mg) was added. Hydrogen was introduced into the reaction system and the reaction mixture was stirred for 12 hours at room temperature. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration. The solvent was removed using a rotary evaporator to afford the target product 2-amino-N,N-dimethylbenzenesulfonamide (2 g, yield: 92%).
References
[1] Patent: EP3202765, 2017, A1. Location in patent: Paragraph 0157; 0158; 0146; 0147
[2] Patent: CN105524045, 2016, A. Location in patent: Paragraph 0261; 0262; 0263
[3] Russian Journal of General Chemistry, 1999, vol. 69, # 6, p. 962 - 968
[4] Patent: WO2004/22534, 2004, A1. Location in patent: Page 102
[5] Patent: US2014/271955, 2014, A1. Location in patent: Paragraph 0766; 0767
2-amino-N,N-dimethylbenzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-amino-N,N-dimethylbenzenesulfonamide Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 2-amino-N,N-dimethylbenzenesulfonamide manufacturers
- Product
- 2-Amino-N,N-dimethylbenzenesulfonamide 54468-86-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09