ChemicalBook > CAS DataBase List > PHTHALAZIN-5-AMINE

PHTHALAZIN-5-AMINE

Product Name: PHTHALAZIN-5-AMINE
CAS No.: 102072-84-4
Chemical Name: PHTHALAZIN-5-AMINE
Synonyms: 5-Phthalazinamine;PHTHALAZIN-5-AMINE;5-AMINO-PHTHALAZINE;Quinoxalin-5-ylamine;5-Aminophthalazine - [A72106]
CBNumber: CB7173949
Molecular Formula: C8H7N3
Formula Weight: 145.16
MOL File: 102072-84-4.mol

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PHTHALAZIN-5-AMINE Property

Melting point:: 223-224 °C(Solv: methanol (67-56-1))
Boiling point:: 423.2±20.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.32±0.30(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A616075
Product name: 5-Aminophthalazine
Packaging: 500mg
Price: $290
Updated: 2021/12/16

AK Scientific

Product number: X8590
Product name: 5-Aminophthalazine
Packaging: 100mg
Price: $122
Updated: 2021/12/16

AK Scientific

Product number: X8590
Product name: 5-Aminophthalazine
Packaging: 250mg
Price: $136
Updated: 2021/12/16

Matrix Scientific

Product number: 071917
Product name: 5-Aminophthalazine
Purity: 95+%
Packaging: 500mg
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: X8590
Product name: 5-Aminophthalazine
Packaging: 1g
Price: $227
Updated: 2021/12/16

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PHTHALAZIN-5-AMINE Chemical Properties,Usage,Production

Uses

5-Aminophthalazine is a building block that was used as a reactant in the synthetic preparation of ezrin inhibitors targeting metastatic osteosarcoma.

Synthesis

89898-86-2

102072-84-4

General procedure for the synthesis of 5-amino phthalazine using 5-nitro phthalazine as starting material: 0.88 g (5.0 mmol) of 5-nitro phthalazine was dissolved in 30 mL of tetrahydrofuran at 50 °C, followed by the addition of 4.37 g (25.1 mmol) of sodium bisulfite dissolved in a solution of 15 mL of water. The reaction mixture was stirred continuously at 50 °C for 15 min. Upon completion of the reaction, the organic phase was extracted with ethyl acetate (3 x 100 mL) and the combined organic phases were washed with brine (50 mL) and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give the crude product as a bright yellow precipitate. The crude product was recrystallized in hot methanol to give 0.49 g (67% yield) of purified 5-aminophthalazine. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100.17 MHz, DMSO-d6) as follows: 1H NMR δ: 9.80 (s, 1H), 9.60 (s, 1H), 7.60 (dd, J = 4.6, 7.6 Hz, 1H), 7.20 (dd, J = 1.9, 4.6 Hz, 1H), 7.02 (d, J = 7.6 Hz, 1H), 6.50 (s, 2H); 13C NMR δ: 150.1,146.5,145.1,133.2,126.1,114.7,114.1,112.2.

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 478 - 487
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2577 - 2580
[5] Patent: US2006/116368, 2006, A1. Location in patent: Page/Page column 35; 36

PHTHALAZIN-5-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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102072-84-4, PHTHALAZIN-5-AMINERelated Search:

N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine 5-AMINO-6-METHYLAMINOQUINOXALINE, DIHYDROCHLORIDE SALT 2-METHYL-7-METHYLAMINO-8-NITRO-QUINOXALINE 6-METHYLAMINO-5-NITROQUINOXALINE 1,7-DIAMINOPHENAZINE 2-METHYL-7-METHYLAMINO-D3-8-NITRO-QUINOXALINE 2-METHYL-7-METHYLAMINO-8-AMINO-QUINOXALINE 1,6-Diaminophenazine 5-NITROQUINOXALINE PHTHALAZIN-5-AMINE 1,6-DINITROPHENAZINE 1,8-DIAMINO-2,7-DIMETHYLPHENAZINE 1,7-DINITROPHENAZINE 1,3-diamino-5-phenylphenazinium chloride 1,3-diamino-5-methylphenazinium chloride 1-NITROPHENAZINE 5-AMINO-QUINOXALINE-2,3-DIOL 2-METHOXY-PHENAZIN-1-YLAMINE

5-AMINO-PHTHALAZINE

PHTHALAZIN-5-AMINE

Quinoxalin-5-ylamine

5-Phthalazinamine

5-Aminophthalazine - [A72106]

102072-84-4