DULCITOL Property

Melting point:

164-166 °C (lit.)

Boiling point:

275-280 °C (1 mmHg)

Density 

1.1382 (rough estimate)

refractive index 

1.5510 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated)

form 

Crystalline Powder

color 

yellow to tan

BRN 

18991

LogP

5.003 (est)

CAS DataBase Reference

6051-87-2(CAS DataBase Reference)

Safety

Hazard Codes 

Xn,Xi,C,F

Risk Statements 

22-34-11

Safety Statements 

24/25-45-36/37/39-26-16

WGK Germany 

3

RTECS 

QL6200000

F 

3-10

Hazard Note 

Irritant

HS Code 

29329900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DULCITOL Chemical Properties,Usage,Production

Chemical Properties

SLIGHTLY BEIGE CRYSTALLINE POWDER

Uses

beta-Naphthoflavone is a Cytochrome P450 enzyme system inducer. It can also be used in biological study of novel dual-color luciferase reporter assay for simultaneous detection of estrogen and aryl hydrocarbon receptor activation.

Definition

ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.

General Description

β-Naphthoflavone is a polyaromatic hydrocarbon.

Biochem/physiol Actions

β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a). BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.