ChemicalBook > CAS DataBase List > 3-Bromoimidazo[1,2-a]pyrimidine
3-Bromoimidazo[1,2-a]pyrimidine
Uses- Product Name
- 3-Bromoimidazo[1,2-a]pyrimidine
- CAS No.
- 6840-45-5
- Chemical Name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Synonyms
- -Bromoimidazo[1,2-a]pyrimidine;3-BROMOIMIDAZO[1,2-A]PYRIMIDINE;Imidazo[1,2-a]pyrimidine, 3-bromo-;3-BROMOIMIDAZOL-(1,2-A)-PYRIMIDINE;3-Bromoimidazo[1,2-a]pyrimidine 98%;3-Bromoimidazo[1,2-a]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB7175802
- Molecular Formula
- C6H4BrN3
- Formula Weight
- 198.02
- MOL File
- 6840-45-5.mol
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3-Bromoimidazo[1,2-a]pyrimidine Property
- Melting point:
- 158-160
- Density
- 1.89±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 2.55±0.30(Predicted)
- color
- Light brown
- InChI
- InChI=1S/C6H4BrN3/c7-5-4-9-6-8-2-1-3-10(5)6/h1-4H
- InChIKey
- GNHZXUKWLSWKHB-UHFFFAOYSA-N
- SMILES
- C12=NC=C(Br)N1C=CC=N2
- CAS DataBase Reference
- 6840-45-5(CAS DataBase Reference)
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N-Bromosuccinimide Price
TRC
- Product number
- B696335
- Product name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- B696335
- Product name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- B696335
- Product name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-9-Z4
- Product name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
AK Scientific
- Product number
- Q471
- Product name
- 3-Bromoimidazo[1,2-a]pyrimidine
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
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3-Bromoimidazo[1,2-a]pyrimidine Chemical Properties,Usage,Production
Uses
3-Bromoimidozolo[1,2-a]pyrimidine can be used to prepare HPK1 inhibitors.
Synthesis
274-95-3
6840-45-5
Imidazo[1,2-a]pyrimidine (4 g) and sodium acetate (4.3 g) were dissolved in methanol (40 ml) in a 100 ml three-necked round-bottomed flask, followed by cooling the reaction mixture to -10°C. Bromine (5.38 g) was added slowly and dropwise with stirring. Upon completion of the reaction, 1M aqueous sodium sulfide (40 ml) was added to quench the reaction and the mixture was subsequently concentrated under reduced pressure to remove the solvent. Liquid-liquid extraction was carried out via ethyl acetate and water to separate the by-products, and finally the crude product was purified by column chromatography using dichloromethane and methanol as eluents to give 3.2 g of 3-bromoimidazo[1,2-a]pyrimidine.
References
[1] European Journal of Medicinal Chemistry, 1991, vol. 26, # 1, p. 13 - 18
[2] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 5, p. 1170 - 1176
[3] Patent: KR2017/126059, 2017, A. Location in patent: Paragraph 0069; 0072; 0073; 0078; 0079
3-Bromoimidazo[1,2-a]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromoimidazo[1,2-a]pyrimidine manufacturers
Dideu Industries Group Limited
- Product
- 3-Bromoimidazo[1,2-a]pyrimidine 6840-45-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
Career Henan Chemical Co
- Product
- 3-Bromoimidazo[1,2-a]pyrimidine 6840-45-5
- Price
- US $5.50/KG
- Min. Order
- 1ASSAYS
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10
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