ChemicalBook > CAS DataBase List > 3-Morpholinopropanol

3-Morpholinopropanol

Product Name
3-Morpholinopropanol
CAS No.
4441-30-9
Chemical Name
3-Morpholinopropanol
Synonyms
3-Morpholinopropan-1-ol;4-(3-HYDROXYPROPYL)MORPHOLINE;AKOS BC-0903;3-MORPHOLINOPROPANOL;4-MORPHOLINEPROPANOL;3-Morpholino-1-propanol;3-(4-MORPHOLINE)PROPANOL;gamma-morpholinopropanol;3-MORPHOLIN-4-YL-PROPAN-OL;N-HydroxypropanylMorpholine
CBNumber
CB7180037
Molecular Formula
C7H15NO2
Formula Weight
145.2
MOL File
4441-30-9.mol
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3-Morpholinopropanol Property

Melting point:
110-111.5 °C
Boiling point:
240-241 °C(lit.)
Density 
1.049 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4770(lit.)
Flash point:
185 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
pka
15.07±0.10(Predicted)
color 
Light yellow to Yellow to Orange
CAS DataBase Reference
4441-30-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-36
RIDADR 
3267
WGK Germany 
2
RTECS 
QE9104700
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
567280
Product name
4-(3-Hydroxypropyl)morpholine
Purity
95%
Packaging
1g
Price
$27.5
Updated
2023/06/20
Sigma-Aldrich
Product number
567280
Product name
4-(3-Hydroxypropyl)morpholine
Purity
95%
Packaging
5g
Price
$91.7
Updated
2023/06/20
TCI Chemical
Product number
H1355
Product name
4-(3-Hydroxypropyl)morpholine
Purity
>98.0%(GC)
Packaging
25g
Price
$109
Updated
2025/07/31
TRC
Product number
H996355
Product name
4-(3-Hydroxypropyl)morpholine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
H996355
Product name
4-(3-Hydroxypropyl)morpholine
Packaging
500mg
Price
$75
Updated
2021/12/16
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3-Morpholinopropanol Chemical Properties,Usage,Production

Uses

4-(3-Hydroxypropyl)morpholine may be used in the synthesis of macrocyclic urea compounds, which can act as potent Chk1 inhibitors.

Synthesis

110-91-8

627-18-9

4441-30-9

To the reaction flask was added 913.5 g of toluene as solvent, followed by 174 g of morpholine and 556 g of 3-bromo-1-propanol. Under stirring conditions, 331.2 g of potassium carbonate was slowly added as a base. The reaction mixture was heated to 75-80 °C and the reaction was maintained at this temperature with stirring for 8 hours. Upon completion of the reaction, pressurized filtration was performed to remove solid impurities. Subsequently, the filtrate was concentrated to remove toluene and unreacted feedstocks, resulting in 278.4 g of a pale yellow oily liquid, the target product 3-(4-morpholinyl)-1-propanol. The molar yield of this step was 96% and the purity of the product was 98.5%.

References

[1] Patent: CN106045942, 2016, A. Location in patent: Paragraph 0023; 0020
[2] Patent: CN103382206, 2016, B. Location in patent: Paragraph 0235-0238
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[4] Patent: WO2004/108677, 2004, A1. Location in patent: Page 141
[5] Patent: US6265411, 2001, B1

3-Morpholinopropanol Preparation Products And Raw materials

Raw materials

Preparation Products

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4441-30-9, 3-MorpholinopropanolRelated Search:

1-Propanol 2-Hydroxypropyl-β-cyclodextrin Hydroxypropyl starch Moroxydine Hydroxypropyl methyl cellulose Tridemorph Hydroxypropyl cellulose Dimethomorph Moroxydine hydrochloride 2-Deoxy-D-xylose 7-ACETYLLYCOPSAMINE XANTHORRHIZOL [5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-(3,4,5-trihydroxyoxan-2-yl)oxy-phosphoryl]oxy-phosphinic acid D-[2-2H]XYLOSE L-xylulose Xanthophyll 9H-Xanthen-9-one, 2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-1,3,6,7-tetrahydroxy- 4-[(1R)-1,5-Dimethyl-4-hexen-1-yl]-2-cyclohexen-1-one

  • gamma-morpholinopropanol
  • 3-(4-Morpholinyl)-1-propanol, 3-Morpholinopropanol
  • 3-Morpholino-1-propanol
  • 3-Morpholinopropan-1-ol
  • N-HydroxypropanylMorpholine
  • 3-Morpholinopropanol 3-Morpholino-1-propanol
  • 4-(3-Hydroxypropyl)Morpholine, 98%+
  • 4-(3-Hydroxypropyl)morpholine 95%
  • AKOS BC-0903
  • 3-(4-MORPHOLINE)PROPANOL
  • 3-(4-morpholinyl)-1-propanol
  • 4-(3-HYDROXYPROPYL)MORPHOLINE
  • 3-MORPHOLIN-4-YL-PROPAN-1-OL
  • 3-MORPHOLIN-4-YL-PROPAN-OL
  • 3-MORPHOLINOPROPANOL
  • 4-MORPHOLINEPROPANOL
  • 4-(3-Hydroxypropyl)morpholine&gt
  • 3-Morpholin-4-yl-1-propanol
  • 4441-30-9
  • Building Blocks
  • Morpholines
  • Heterocyclic Building Blocks
  • pharmacetical