Artemifone

Product Name: Artemifone
CAS No.: 255730-18-8
Chemical Name: Artemifone
Synonyms: Artemisone;Artemifone;BAY 44-9585;Artemisone, 10 mM in DMSO;YHVQDGXHTCSGBJ-AKSSTEKGSA-N;Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone;10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin;(5aS,6R,8aR,12S)-3,6-dimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-dione;4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide;4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
CBNumber: CB71856023
Molecular Formula: C19H31NO6S
Formula Weight: 401.52
MOL File: 255730-18-8.mol

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Artemifone Property

Boiling point:: 536.5±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 130 mg/mL (323.77 mM)
form: Solid
pka: 2.99±0.20(Predicted)
color: White to off-white

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Safety

HS Code: 9999999999

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0015600
Product name: Artemisone
Purity: 98.09%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0045908
Product name: ARTEMISONE
Purity: 95.00%
Packaging: 5MG
Price: $454.93
Updated: 2021/12/16

ChemScene

Product number: CS-0015600
Product name: Artemisone
Purity: 98.09%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 33204
Product name: Artemisone
Packaging: 1mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0015600
Product name: Artemisone
Purity: 98.09%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

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Artemifone Chemical Properties,Usage,Production

Uses

Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].

in vivo

Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED₅₀ of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration^[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS^[1]

IC 50

Plasmodium

References

[1] Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. DOI:10.1093/jac/dkl563
[2] Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.

Artemifone Preparation Products And Raw materials

Raw materials

Preparation Products

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Artemifone Suppliers

China 26 France 1 India 1 United States 7 Global 35

BOC Sciences

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Shanghai Hekang Biotechnology Co., Ltd.

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Email: youchemicals@gmail.com
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Shanghai EFE Biological Technology Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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255730-18-8, ArtemifoneRelated Search:

Artemisinin Arterolane Artesunate

Artemifone

10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin

Artemisone

BAY 44-9585

YHVQDGXHTCSGBJ-AKSSTEKGSA-N

4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide

Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide

Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone

(5aS,6R,8aR,12S)-3,6-dimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-dione

4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide

Artemisone, 10 mM in DMSO

255730-18-8

C19H31NO6S