1H-Indazol-5-ol, 4-chloro-
- Product Name
- 1H-Indazol-5-ol, 4-chloro-
- CAS No.
- 478834-25-2
- Chemical Name
- 1H-Indazol-5-ol, 4-chloro-
- Synonyms
- 4-Chloro-1H-indazol-5-ol;1H-Indazol-5-ol, 4-chloro-;4-Chloro-4-hydroxy-1H-indazole
- CBNumber
- CB71868419
- Molecular Formula
- C7H5ClN2O
- Formula Weight
- 168.58
- MOL File
- 478834-25-2.mol
1H-Indazol-5-ol, 4-chloro- Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C384633
- Product name
- 4-Chloro-1H-indazol-5-ol
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 6007DA
- Product name
- 4-Chloro-1H-indazol-5-ol
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- CM123050
- Product name
- 4-chloro-1H-indazol-5-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $234
- Updated
- 2021/12/16
- Product number
- CD11118183
- Product name
- 4-Chloro-1H-indazol-5-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- 478834252
- Product name
- 4-Chloro-1H-indazol-5-ol
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
1H-Indazol-5-ol, 4-chloro- Chemical Properties,Usage,Production
Chemical Properties
Solid
Synthesis
15579-15-4
478834-25-2
At room temperature, 1H-indazol-5-ol (1.60 g, 11.9 mmol) was dissolved in tetrahydrofuran (50 mL) and N-chlorosuccinimide (1.59 g, 11.9 mmol) was added. After 1 hour of reaction, the mixture was warmed up to 40 °C to continue the reaction for 2 hours, followed by warming up to 50 °C for 5 hours. Upon completion of the reaction, the reaction solution was poured into water (100 mL) and extracted with ethyl acetate (3 × 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 4-chloro-5-hydroxy-1H-indazole (1.7365 g, 86% yield).1H-NMR (DMSO-d6) δ: 7.09 (1H, d, J = 8.8 Hz), 7.33 (1H, d, J = 8.8 Hz), 7.90 (1H, s) 9.71 (1H, s), 13.10 (1H, s).
References
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 120
1H-Indazol-5-ol, 4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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