ChemicalBook > CAS DataBase List > AMD 070

AMD 070

Product Name
AMD 070
CAS No.
558447-26-0
Chemical Name
AMD 070
Synonyms
AMD 070;AMD-11070;Mavorixafor;AMD070/AMD-070;AMD-070 (AMD-11070);Mavorixafor(AMD-070);Mavorixafor, 10 mM in DMSO;Mavorixafor (AMD-070, X4P-001);N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI);AMD 070 N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
CBNumber
CB71872364
Molecular Formula
C21H27N5
Formula Weight
349.47
MOL File
558447-26-0.mol
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AMD 070 Property

Melting point:
108-110℃
Boiling point:
597.0±50.0 °C(Predicted)
Density 
1.21
storage temp. 
Store at -20°C
solubility 
≥17.45 mg/mL in DMSO; ≥44.5 mg/mL in EtOH; ≥7.47 mg/mL in H2O with gentle warming
form 
oil
pka
11.65±0.10(Predicted)
color 
brown
InChIKey
WVLHHLRVNDMIAR-IBGZPJMESA-N
SMILES
C(N(CC1NC2=CC=CC=C2N=1)[C@@H]1C2=C(CCC1)C=CC=N2)CCCN
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28439
Product name
Mavorixafor
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
28439
Product name
Mavorixafor
Packaging
10mg
Price
$186
Updated
2024/03/01
TRC
Product number
B201930
Product name
N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine
Packaging
25mg
Price
$475
Updated
2021/12/16
ApexBio Technology
Product number
A3173
Product name
AMD-070
Packaging
25mg
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167492
Product name
N-((1H-BENZO[D]IMIDAZOL-2-YL)METHYL)-N-(4-AMINOBUTYL)-5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE
Purity
95.00%
Packaging
5MG
Price
$500.95
Updated
2021/12/16
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AMD 070 Chemical Properties,Usage,Production

Uses

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine is a potent CXCR4 inhibitor that inhibits X4 HIV-1 replication and the gp120/CXCR4 interaction. It also has therapeutic potential for developing treatments for B-RAF wild-type and mutated melanomas.

Definition

ChEBI: AMD 070 is an aminoquinoline.

in vivo

Mavorixafor (AMD-070) (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss[2].

IC 50

125I-SDF-CXCR4: 13 nM (IC50); HIV-1 (NL4.3 strain): 1 nM (IC50, in MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC50, in PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, in MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, in PBMCs)

AMD 070 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMD 070 Suppliers

China 80 United Kingdom 1 United States 11 Global 92
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
ApexBio Technology
Tel
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Interchim Inc.
Tel
--
Fax
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Email
web@interchiminc.com
Country
United States
ProdList
301
Advantage
50
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View Lastest Price from AMD 070 manufacturers

Career Henan Chemical Co
Product
AMD 070 558447-26-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

558447-26-0, AMD 070Related Search:


  • AMD 070
  • AMD-11070
  • N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
  • N'-(1H-Benzimidazol-2-ylmethyl)-N'-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
  • AMD 070 N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
  • 1,4-ButanediaMine, N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-
  • (S)-N1-((1H-benzo[d]iMidazol-2-yl)Methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diaMine
  • AMD070/AMD-070
  • (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diami
  • 1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-
  • N'-(1h-benzimidazol-2-ylmethyl)-n'-[(8s)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
  • Mavorixafor
  • Mavorixafor(AMD-070)
  • Mavorixafor,CXCR,AMD 070,Human immunodeficiency virus,AMD070,HIV,inhibit,CXC chemokine receptors,Inhibitor
  • Mavorixafor (AMD-070, X4P-001)
  • Mavorixafor, 10 mM in DMSO
  • AMD-070 (AMD-11070)
  • 558447-26-0