METHYL 3-OXOTETRADECANOATE
Synthesis- Product Name
- METHYL 3-OXOTETRADECANOATE
- CAS No.
- 22348-97-6
- Chemical Name
- METHYL 3-OXOTETRADECANOATE
- Synonyms
- Orlistat Impurity 61;Metyl lauroyl acetate;Methyl β-KetoMyristate;Methyl b-ketomyristate;Methyl Lauroyl Acetate;METHYL 3-OXOTETRADECANOATE;METHYL 3-KETOTETRADECANOATE;3-Oxomyristic acid methyl ester;3-Ketomyristic acid methyl ester;3-Oxotetradecanoic acid methyl ester
- CBNumber
- CB7187955
- Molecular Formula
- C15H28O3
- Formula Weight
- 256.38
- MOL File
- 22348-97-6.mol
METHYL 3-OXOTETRADECANOATE Property
- Melting point:
- 29-30°C
- Boiling point:
- 137-139 °C(Press: 0.9 Torr)
- Density
- 0.926±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.65±0.46(Predicted)
- color
- Light Yellow to Yellow
- LogP
- 5.500 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M325865
- Product name
- Methyl3-Oxotetradecanoate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 089325
- Product name
- Methyl 3-oxotetradecanoate
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 089325
- Product name
- Methyl 3-oxotetradecanoate
- Packaging
- 5g
- Price
- $670
- Updated
- 2021/12/16
- Product number
- CHM0067306
- Product name
- METHYL 3-OXOTETRADECANOATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- Q506
- Product name
- Methyl3-Oxotetradecanoate
- Packaging
- 5g
- Price
- $873
- Updated
- 2021/12/16
METHYL 3-OXOTETRADECANOATE Chemical Properties,Usage,Production
Synthesis
The carboxylic acid (13.8 g, 69 mmol, 1.0 equivalents) was dissolved in dry THF under an inert atmosphere and cooled to 0 ºC. CDI (13.4 g, 83 mmol, 1.2 equivalents) was then added in small portions over several minutes. After 10 min, the reaction was allowed to warm slowly to room temperature and was then stirred for 1 h. In a separate flflask, monomethyl malonate (9.8g, 83 mmol, 1.2 equivalents) was dissolved in THF under an inert atmosphere and cooled to −78 ºC. To this solution was added dibutylmagnesium (1.0 M in heptane, 0.6 equivalents). A white solid formed instantly on addition of the base. After 10 min, the reaction was warmed to room temperature and stirred for 1 h. The acylimidazole was then added by cannula to the flflask containing the magnesium salt. The resulting slurry was stirred for 3 days. The reaction mixture was then concentrated on a rotary evaporator and the residue redissolved in EtOAc. The resulting solution was washed with 1.2 M HCl, saturated aqueous NaHCO3, and brine. The organic phase was dried over sodium sulfate, fifiltered, concentrated, and the residue purifified by flflash chromatography (7:1 hexanes:EtOAc) to give the β-keto ester (14.7g, 83%).
Reference: Durham, T. B.; Miller, M. J. J. Org. Chem. 2003, 68, 27–34.
Chemical Properties
Yellow Crystalline Solid
Uses
Methyl 3-Oxotetradecanoate (cas# 22348-97-6) is a compound useful in organic synthesis.
METHYL 3-OXOTETRADECANOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3-OXOTETRADECANOATE manufacturers
- Product
- METHYL 3-OXOTETRADECANOATE 22348-97-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-24