1-bromo-2,5-dimethyl-4-nitrobenzene
- Product Name
- 1-bromo-2,5-dimethyl-4-nitrobenzene
- CAS No.
- 15540-81-5
- Chemical Name
- 1-bromo-2,5-dimethyl-4-nitrobenzene
- Synonyms
- 4-Bromo-2,5-dimethylnitrobenzene;1-bromo-2,5-dimethyl-4-nitrobenzene;Benzene, 1-bromo-2,5-dimethyl-4-nitro-;1-Bromo-2,5-dimethyl-4-nitrobenzene 98%;1-Bromo-2,5-dimethyl-4-nitro-benzene（2-Bromo-5-nitro-p-xylene）
- CBNumber
- CB71882877
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 15540-81-5.mol
1-bromo-2,5-dimethyl-4-nitrobenzene Property
- Melting point:
- 70 °C
- Boiling point:
- 288.8±35.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- light green to green Solid
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B691663
- Product name
- 1-Bromo-2,5-dimethyl-4-nitro-benzene
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4754-9-47
- Product name
- 1-Bromo-2,5-dimethyl-4-nitrobenzene
- Packaging
- 1g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 9765AH
- Product name
- 1-Bromo-2,5-dimethyl-4-nitrobenzene
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 4754-9-47
- Product name
- 1-Bromo-2,5-dimethyl-4-nitrobenzene
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- HCH0069328
- Product name
- 1-BROMO-2,5-DIMETHYL-4-NITRO-BENZENE
- Purity
- 97.00%
- Packaging
- 5MG
- Price
- $502.99
- Updated
- 2021/12/16
1-bromo-2,5-dimethyl-4-nitrobenzene Chemical Properties,Usage,Production
Synthesis
3460-29-5
15540-81-5
General Steps: Part A-Preparation of copper (I) bromide solution: dissolve copper (I) bromide (72.5 g, 505 mmol) in 37% hydrochloric acid (150 mL) and heat to 80°C until a clarified solution is formed. Part B-Diazotization and Sandmeyer bromination: to a concentrated hydrochloric acid solution (150 mL) of 2,5-dimethyl-4-nitroaniline (21 g, 126 mmol), a mixture of saturated sodium nitrite solution (1.7 g, 253 mmol) and water (20 mL) was added slowly and dropwise at 0°C with continuous stirring for 30 min. Subsequently, copper (I) bromide solution prepared in part A was added slowly and dropwise at the same temperature. After addition, the reaction mixture was warmed up to 80 °C and maintained for 1 hour. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the target product 1-bromo-2,5-dimethyl-4-nitrobenzene (22 g, 76% yield) was purified by column chromatography (eluent: hexane/ethyl acetate, 8:2).
References
[1] Patent: WO2018/211442, 2018, A1. Location in patent: Page/Page column 71-72
[2] Recueil des Travaux Chimiques des Pays-Bas, 1956, vol. 75, p. 1137,1138, 1149
1-bromo-2,5-dimethyl-4-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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