BQ-123 SODIUM SALT
- Product Name
- BQ-123 SODIUM SALT
- CAS No.
- 136553-81-6
- Chemical Name
- BQ-123 SODIUM SALT
- Synonyms
- ONIST;BQ-123;BQ-518;PMZ 2123;BQ-123 SODIUM SALT;BQ-123;BQ 123;BQ123;ETA-RECEPTOR ANTAGONIST;M.W. 610.70 C31H42N6O7;C(DTRP-DASP-PRO-DVAL-LEU);D-TRP-D-ASP-PRO-D-VAL-LEU
- CBNumber
- CB7188725
- Molecular Formula
- C31H42N6O7
- Formula Weight
- 610.7
- MOL File
- 136553-81-6.mol
BQ-123 SODIUM SALT Property
- Boiling point:
- 1053.6±65.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble to 0.40 mg/ml in sterile
- form
- lyophilized powder
- pka
- 4.04±0.10(Predicted)
- Water Solubility
- Soluble in water (0.4 mg/ml)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B150
- Product name
- BQ-123
- Purity
- ≥99%, sodium salt, lyophilized powder
- Packaging
- 200μg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- B150
- Product name
- BQ-123
- Purity
- ≥99%, sodium salt, lyophilized powder
- Packaging
- 1mg
- Price
- $172.4
- Updated
- 2024/03/01
- Product number
- 05-23-3831
- Product name
- BQ-123, Sodium Salt
- Purity
- A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).
- Packaging
- 1MG
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 05-23-3831
- Product name
- BQ-123, Sodium Salt
- Purity
- A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).
- Packaging
- 5MG
- Price
- $789
- Updated
- 2023/06/20
- Product number
- J66169
- Product name
- BQ-123
- Packaging
- 0.5mg
- Price
- $75.9
- Updated
- 2023/06/20
BQ-123 SODIUM SALT Chemical Properties,Usage,Production
Uses
BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.
Definition
ChEBI: BQ 123 is a cyclic peptide.
Biological Activity
bq-123 is a potent and selective antagonist of eta endothelin receptor with ki values of 1.4 and 1500 nm for eta and etb receptors, respectively.endothelin receptor is a g protein-coupled receptor. eta receptor increases intracellular-free ca2+. also, activation of eta receptor increases vasoconstriction and blood pressure.bq-123 is a selective eta receptor antagonist. in the eta-expressing cells, bq123 (10-6 m) inhibited endothelin-1 (et-1) (10-6 m)-induced [ca2+]i increase by 95% [1]. in rat vascular smooth muscle cells (vsmc), bq-123 inhibited et-1 receptor binding, cellular contraction, [ca2+ ]i mobilization, [3h]thymidine incorporation, map kinase activation and mtt reduction induced by et-1. however, bq-123 didn’t inhibit angiotensin ii (ang ii)- and arginine vasopressin (avp)-induced increases in map kinase activity and [ca2+]i mobilization [2].in spontaneously hypertensive rats (shr), renin hypertensive rats and normotensive rats, bq-123 (16 nm/kg/min) reduced mean arterial pressure in a dose-dependent way in shr. also, bq-123 lowered blood pressure in both renin hypertensive rats and normotensive rats [3]. in a kidney transplantation rat model with reperfusion injury, bq-123 prevented reperfusion injury and inhibited the synthesis and release of et-1,2 [4].
Biochem/physiol Actions
Selective ETA endothelin receptor antagonist.
storage
-20°C
References
[1]. sakamoto a, yanagisawa m, sawamura t, et al. distinct subdomains of human endothelin receptors determine their selectivity to endothelina-selective antagonist and endothelinb-selective agonists. j biol chem, 1993, 268(12): 8547-8553.
[2]. guo x, okada k, fujita n, et al. inhibitory effect of bq-123 on endothelin-1-stimulated mitogen-activated protein kinase and cell growth of rat vascular smooth muscle cells. hypertens res, 1996, 19(1): 23-30.
[3]. douglas sa, gellai m, ezekiel m, et al. bq-123, a selective endothelin subtype a-receptor antagonist, lowers blood pressure in different rat models of hypertension. j hypertens, 1994, 12(5): 561-567.
[4]. büyükgebiz o, aktan ao, haklar g, et al. bq-123, a specific endothelin (eta) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation. transpl int, 1996, 9(3): 201-207.
BQ-123 SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BQ-123 SODIUM SALT manufacturers
- Product
- BQ-123 SODIUM SALT 136553-81-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13