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BQ-123 SODIUM SALT

Product Name
BQ-123 SODIUM SALT
CAS No.
136553-81-6
Chemical Name
BQ-123 SODIUM SALT
Synonyms
ONIST;BQ-123;BQ-518;PMZ 2123;BQ-123 SODIUM SALT;BQ-123;BQ 123;BQ123;ETA-RECEPTOR ANTAGONIST;M.W. 610.70 C31H42N6O7;C(DTRP-DASP-PRO-DVAL-LEU);D-TRP-D-ASP-PRO-D-VAL-LEU
CBNumber
CB7188725
Molecular Formula
C31H42N6O7
Formula Weight
610.7
MOL File
136553-81-6.mol
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BQ-123 SODIUM SALT Property

Boiling point:
1053.6±65.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble to 0.40 mg/ml in sterile
form 
lyophilized powder
pka
4.04±0.10(Predicted)
color 
White to off-white
Water Solubility 
Soluble in water (0.4 mg/ml)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B150
Product name
BQ-123
Purity
≥99%, sodium salt, lyophilized powder
Packaging
200μg
Price
$155
Updated
2024/03/01
Sigma-Aldrich
Product number
B150
Product name
BQ-123
Purity
≥99%, sodium salt, lyophilized powder
Packaging
1mg
Price
$172.4
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-3831
Product name
BQ-123, Sodium Salt
Purity
A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).
Packaging
1MG
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-3831
Product name
BQ-123, Sodium Salt
Purity
A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).
Packaging
5MG
Price
$789
Updated
2023/06/20
Alfa Aesar
Product number
J66169
Product name
BQ-123
Packaging
0.5mg
Price
$75.9
Updated
2023/06/20
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BQ-123 SODIUM SALT Chemical Properties,Usage,Production

Uses

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Definition

ChEBI: BQ 123 is a cyclic peptide.

Biological Activity

bq-123 is a potent and selective antagonist of eta endothelin receptor with ki values of 1.4 and 1500 nm for eta and etb receptors, respectively.endothelin receptor is a g protein-coupled receptor. eta receptor increases intracellular-free ca2+. also, activation of eta receptor increases vasoconstriction and blood pressure.bq-123 is a selective eta receptor antagonist. in the eta-expressing cells, bq123 (10-6 m) inhibited endothelin-1 (et-1) (10-6 m)-induced [ca2+]i increase by 95% [1]. in rat vascular smooth muscle cells (vsmc), bq-123 inhibited et-1 receptor binding, cellular contraction, [ca2+ ]i mobilization, [3h]thymidine incorporation, map kinase activation and mtt reduction induced by et-1. however, bq-123 didn’t inhibit angiotensin ii (ang ii)- and arginine vasopressin (avp)-induced increases in map kinase activity and [ca2+]i mobilization [2].in spontaneously hypertensive rats (shr), renin hypertensive rats and normotensive rats, bq-123 (16 nm/kg/min) reduced mean arterial pressure in a dose-dependent way in shr. also, bq-123 lowered blood pressure in both renin hypertensive rats and normotensive rats [3]. in a kidney transplantation rat model with reperfusion injury, bq-123 prevented reperfusion injury and inhibited the synthesis and release of et-1,2 [4].

Biochem/physiol Actions

Selective ETA endothelin receptor antagonist.

storage

-20°C

References

[1]. sakamoto a, yanagisawa m, sawamura t, et al. distinct subdomains of human endothelin receptors determine their selectivity to endothelina-selective antagonist and endothelinb-selective agonists. j biol chem, 1993, 268(12): 8547-8553.
[2]. guo x, okada k, fujita n, et al. inhibitory effect of bq-123 on endothelin-1-stimulated mitogen-activated protein kinase and cell growth of rat vascular smooth muscle cells. hypertens res, 1996, 19(1): 23-30.
[3]. douglas sa, gellai m, ezekiel m, et al. bq-123, a selective endothelin subtype a-receptor antagonist, lowers blood pressure in different rat models of hypertension. j hypertens, 1994, 12(5): 561-567.
[4]. büyükgebiz o, aktan ao, haklar g, et al. bq-123, a specific endothelin (eta) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation. transpl int, 1996, 9(3): 201-207.

BQ-123 SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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BQ-123 SODIUM SALT Suppliers

China 104 France 1 Germany 4 India 1 Japan 1 Switzerland 2 United Kingdom 6 United States 19 Global 138
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Alexis Corporation
Tel
--
Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
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View Lastest Price from BQ-123 SODIUM SALT manufacturers

Career Henan Chemical Co
Product
BQ-123 SODIUM SALT 136553-81-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

136553-81-6, BQ-123 SODIUM SALTRelated Search:

BQ-123 SODIUM SALT JKC-301 [3H]BQ 123 C(DILE-LEU-DTRP-DASP-PRO)

  • BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE
  • cyclo(Trp-Asp-Pro-Val-Leu)
  • BQ-123
  • BQ-123 SODIUM SALT
  • ETA-RECEPTOR ANTAGONIST
  • C(DTRP-DASP-PRO-DVAL-LEU)
  • CYCLO (D-ALPHA-ASPARTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL)
  • CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP)
  • CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA)
  • CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU)
  • CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT
  • D-TRP-D-ASP-PRO-D-VAL-LEU
  • M.W. 610.70 C31H42N6O7
  • BQ-518
  • Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-)
  • Cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu-)
  • Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]
  • BQ-123;BQ 123;BQ123
  • 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
  • PMZ 2123
  • Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
  • BQ-123 >=99%, sodium salt, lyophilized powder
  • Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl
  • 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid
  • 136553-81-6 BQ-123 SODIUM SALT
  • ONIST
  • ETA-Receptor Antagonist [BQ-123] sodium salt
  • inhibit,blood,Endothelin Receptor,artery,BQ-123,pressure,muscle,smooth,cells,BQ 123,Inhibitor,pulmonary
  • 136553-81-6
  • C31H42N6O7
  • Endothelins
  • Peptides
  • Antagonists
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Antagonists
  • Endothelins
  • Peptides for Cell Biology
  • Endothelin receptor