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4-(2-Hydroxyethoxy)benzaldehyde

Product Name
4-(2-Hydroxyethoxy)benzaldehyde
CAS No.
22042-73-5
Chemical Name
4-(2-Hydroxyethoxy)benzaldehyde
Synonyms
p-(2-Hydroxyethoxy)benzaldehyde;AKOS B030687;TIMTEC-BB SBB010472;ASINEX-REAG BAS 12719716;Hydroxyethoxybenzaldehyde;4-(2-HYDROXYETHOXY)BENZALDEHYDE;4-(2-HYDROXYETHOXY)BENZALOIEHYDE;Benzaldehyde, 4-(2-hydroxyethoxy)-;4-(2-Hydroxyethoxy)benzaldehyde>Benzaldehyde, p-(2-hydroxyethoxy)-
CBNumber
CB7188952
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
22042-73-5.mol
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4-(2-Hydroxyethoxy)benzaldehyde Property

Melting point:
36-38°C
Boiling point:
335.2±17.0 °C(Predicted)
Density 
1.194±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
14.14±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
InChI
InChI=1S/C9H10O3/c10-5-6-12-9-3-1-8(7-11)2-4-9/h1-4,7,10H,5-6H2
InChIKey
VCDGTEZSUNFOKA-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OCCO)C=C1
LogP
0.730 (est)
CAS DataBase Reference
22042-73-5(CAS DataBase Reference)
EPA Substance Registry System
Benzaldehyde, 4-(2-hydroxyethoxy)- (22042-73-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2912490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H0859
Product name
4-(2-Hydroxyethoxy)benzaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$47
Updated
2025/07/31
TCI Chemical
Product number
H0859
Product name
4-(2-Hydroxyethoxy)benzaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$172
Updated
2025/07/31
ChemScene
Product number
CS-M2027
Product name
4-(2-Hydroxyethoxy)benzaldehyde
Packaging
10g
Price
$91
Updated
2021/12/16
AK Scientific
Product number
J54935
Product name
4-(2-Hydroxyethoxy)benzaldehyde
Packaging
25g
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-M2027
Product name
4-(2-Hydroxyethoxy)benzaldehyde
Packaging
25g
Price
$201
Updated
2021/12/16
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4-(2-Hydroxyethoxy)benzaldehyde Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 2267, 1995 DOI: 10.1021/jo00112a059

Synthesis

123-08-0

107-07-3

22042-73-5

GENERAL METHODS: A mixture of 4-hydroxybenzaldehyde (1 mmol), 2-chloroethanol (1 mmol) and potassium carbonate (3 mmol) in dimethylsulfoxide (DMSO) was heated and refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water and extracted with dichloromethane. The organic phases were combined and concentrated under reduced pressure to remove the solvent, and the resulting residue was purified by column chromatography to afford the target product 4-(2-hydroxyethoxy)benzaldehyde (3m). 4.3.1. 4-(2-Hydroxyethoxy)benzaldehyde (3m) was a yellow oil in 80% yield; 1H NMR (400 MHz, CDCl3): δ 3.03 (1H, s, OH), 3.98 (2H, t, J = 4.4 Hz, -CH2-), 4.14 (2H, t, J = 4.4 Hz, -OCH2-), 6.98 (2H , d, J = 8.4 Hz, Ar-H), 7.80 (2H, d, J = 8.4 Hz, Ar-H), 9.84 (1H, s, CHO) ppm.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 21, p. 6519 - 6522
[2] Journal of the American Chemical Society, 2008, vol. 130, # 50, p. 16996 - 17003
[3] European Journal of Medicinal Chemistry, 2009, vol. 44, # 10, p. 4235 - 4243
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 2, p. 639 - 646
[5] Journal of Organometallic Chemistry, 2018, vol. 870, p. 38 - 50

4-(2-Hydroxyethoxy)benzaldehyde Preparation Products And Raw materials

Raw materials

Acetonitrile N,N-Dimethylformamide Potassium carbonate 2-Chloroethanol 4-Hydroxybenzaldehyde Sodium carbonate

Preparation Products

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4-(2-Hydroxyethoxy)benzaldehyde Suppliers

Americas 1 China 118 Europe 3 Germany 3 India 4 Japan 3 Russia 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 7 United States 16 Global 159
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from 4-(2-Hydroxyethoxy)benzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(2-Hydroxyethoxy)benzaldehyde 22042-73-5
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15
Career Henan Chemical Co
Product
4-(2-Hydroxyethoxy)benzaldehyde 22042-73-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

22042-73-5, 4-(2-Hydroxyethoxy)benzaldehydeRelated Search:

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  • TIMTEC-BB SBB010472
  • 4-(2-HYDROXYETHOXY)BENZALDEHYDE
  • Hydroxyethoxybenzaldehyde
  • 4-(2-HYDROXYETHOXY)BENZALOIEHYDE
  • 4-(2-HYDROXYETHOXY)BENZALDEHYDE 97+%
  • Benzaldehyde, p-(2-hydroxyethoxy)-
  • AKOS B030687
  • ASINEX-REAG BAS 12719716
  • p-(2-Hydroxyethoxy)benzaldehyde
  • 4-(2-Hydroxyethoxy)benzaldehyde&gt
  • Benzaldehyde, 4-(2-hydroxyethoxy)-
  • 22042-73-5